Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964407591> ?p ?o ?g. }
- W2964407591 endingPage "11" @default.
- W2964407591 startingPage "1" @default.
- W2964407591 abstract "In Alzheimer’s disease (AD), tau pathology manifested in the accumulation of intraneuronal tangles and soluble toxic oligomers emerges as a potential therapeutic target. Multiple anti-tau antibodies inhibiting the formation and propagation of cytotoxic tau or promoting its clearance and degradation have been tested in clinical trials, albeit with the inconclusive outcome. Antibodies against tau protein have been found both in the brain circulatory system and at the periphery, but their origin and role under normal conditions and in AD remain unclear. While it is tempting to assign them a protective role in regulating tau level and removal of toxic variants, the supportive evidence remains sporadic, requiring systematic analysis and critical evaluation. Herein, we review recent data showing the occurrence of tau-reactive antibodies in the brain and peripheral circulation and discuss their origin and significance in tau clearance. Based on the emerging evidence, we cautiously propose that impairments of tau clearance at the periphery by humoral immunity might aggravate the tau pathology in the central nervous system, with implication for the neurodegenerative process of AD." @default.
- W2964407591 created "2019-08-13" @default.
- W2964407591 creator A5009191561 @default.
- W2964407591 creator A5036467116 @default.
- W2964407591 date "2019-08-06" @default.
- W2964407591 modified "2023-10-17" @default.
- W2964407591 title "Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease" @default.
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