FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964436181> ?p ?o ?g. }

• W2964436181 abstract "The impressive potential of biologics has been demonstrated in psoriasis, hidradenitis suppurativa, and urticaria. Numerous biologicals are entering the field for a restricted number of skin disorders. Off-label use of biologics in other recalcitrant skin diseases has increased. Mounting data point to the potential of already existing biologics acting on the IL-17/IL-23 pathway in skin disorders with epidermal hyperkeratosis (e.g., pityriasis rubra pilaris), acneiform inflammation (e.g., hidradenitis suppurativa), and loss of mucosal integrity (e.g., aphthosis). TNF-α blockers are also effective in the latter conditions but seem of particular value in granulomatous (e.g., granuloma annulare) and neutrophilic disorders (e.g., pyoderma gangrenosum). Failure of IL-17 blockade in skin diseases resulting from immune-mediated cell destruction (e.g., alopecia areata and vitiligo) illustrates its limited involvement in Th1-dependent skin immunology. Overall, disappointing results of TNF-α blockers in alopecia areata and vitiligo point to the same conclusion although promising results in toxic epidermal necrolysis suggest TNF-α exerts at least some in vivo Th1-related activities. Acting on both the Th1 and Th17 pathway, ustekinumab has a rather broad potential with interesting results in lupus and alopecia areata. The efficacy of omalizumab in bullous pemphigoid has revealed an IgE-mediated recruitment of eosinophils leading to bullae formation. Reconsidering reimbursement criteria for less common but severe diseases seems appropriate if substantial evidence is available (e.g., pityriasis rubra pilaris). For other disorders, investigator- and industry-initiated randomized clinical trials should be stimulated. They are likely to improve patient outcome and advance our understanding of challenging skin disorders." @default.
• W2964436181 created "2019-08-13" @default.
• W2964436181 creator A5016110684 @default.
• W2964436181 creator A5042653620 @default.
• W2964436181 creator A5081384261 @default.
• W2964436181 date "2019-08-08" @default.
• W2964436181 modified "2023-10-13" @default.
• W2964436181 title "Learning From Success and Failure: Biologics for Non-approved Skin Diseases" @default.
• W2964436181 cites W1123548069 @default.
• W2964436181 cites W150458472 @default.
• W2964436181 cites W1507987965 @default.
• W2964436181 cites W158631941 @default.
• W2964436181 cites W1587669384 @default.
• W2964436181 cites W1602488051 @default.
• W2964436181 cites W1965660444 @default.
• W2964436181 cites W1973040573 @default.
• W2964436181 cites W1998514739 @default.
• W2964436181 cites W2010399250 @default.
• W2964436181 cites W2010921759 @default.
• W2964436181 cites W2027209100 @default.
• W2964436181 cites W2029027628 @default.
• W2964436181 cites W2043264467 @default.
• W2964436181 cites W2046330020 @default.
• W2964436181 cites W2051384021 @default.
• W2964436181 cites W2052581975 @default.
• W2964436181 cites W2057866795 @default.
• W2964436181 cites W2095874574 @default.
• W2964436181 cites W2096806380 @default.
• W2964436181 cites W2101185400 @default.
• W2964436181 cites W2125620933 @default.
• W2964436181 cites W2126423561 @default.
• W2964436181 cites W2126637727 @default.
• W2964436181 cites W2130159507 @default.
• W2964436181 cites W2130854300 @default.
• W2964436181 cites W2135105392 @default.
• W2964436181 cites W2169601473 @default.
• W2964436181 cites W2175027747 @default.
• W2964436181 cites W2180478853 @default.
• W2964436181 cites W2192166578 @default.
• W2964436181 cites W2199733448 @default.
• W2964436181 cites W2204642623 @default.
• W2964436181 cites W2326857287 @default.
• W2964436181 cites W2328041856 @default.
• W2964436181 cites W2464217003 @default.
• W2964436181 cites W2527950261 @default.
• W2964436181 cites W2529885865 @default.
• W2964436181 cites W2555773301 @default.
• W2964436181 cites W2558481139 @default.
• W2964436181 cites W2583703195 @default.
• W2964436181 cites W2588368793 @default.
• W2964436181 cites W2599026830 @default.
• W2964436181 cites W2600029119 @default.
• W2964436181 cites W2610900789 @default.
• W2964436181 cites W2619755001 @default.
• W2964436181 cites W2620280647 @default.
• W2964436181 cites W2725200785 @default.
• W2964436181 cites W2736713079 @default.
• W2964436181 cites W2736915451 @default.
• W2964436181 cites W2755789752 @default.
• W2964436181 cites W2756934266 @default.
• W2964436181 cites W2761661768 @default.
• W2964436181 cites W2766299471 @default.
• W2964436181 cites W2770009799 @default.
• W2964436181 cites W2770407202 @default.
• W2964436181 cites W2772295154 @default.
• W2964436181 cites W2787407277 @default.
• W2964436181 cites W2791075559 @default.
• W2964436181 cites W2793854835 @default.
• W2964436181 cites W2794543298 @default.
• W2964436181 cites W2800087115 @default.
• W2964436181 cites W2800472118 @default.
• W2964436181 cites W2800831089 @default.
• W2964436181 cites W2802013417 @default.
• W2964436181 cites W2803062292 @default.
• W2964436181 cites W2804942936 @default.
• W2964436181 cites W2807500386 @default.
• W2964436181 cites W2878748191 @default.
• W2964436181 cites W2887057743 @default.
• W2964436181 cites W2888011380 @default.
• W2964436181 cites W2889729749 @default.
• W2964436181 cites W2890532892 @default.
• W2964436181 cites W2890887861 @default.
• W2964436181 cites W2891027494 @default.
• W2964436181 cites W2891846602 @default.
• W2964436181 cites W2894720168 @default.
• W2964436181 cites W2895426055 @default.
• W2964436181 cites W2896092856 @default.
• W2964436181 cites W2898832965 @default.
• W2964436181 cites W2900829447 @default.
• W2964436181 cites W2901189024 @default.
• W2964436181 cites W2902740370 @default.
• W2964436181 cites W2903291109 @default.
• W2964436181 cites W2904241235 @default.
• W2964436181 cites W2904815943 @default.
• W2964436181 cites W2908299464 @default.
• W2964436181 cites W2908447894 @default.
• W2964436181 cites W2908503979 @default.
• W2964436181 cites W2908997823 @default.
• W2964436181 cites W2909912328 @default.
• W2964436181 cites W2910838979 @default.

• next