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• W2964461736 endingPage "346" @default.
• W2964461736 startingPage "346" @default.
• W2964461736 abstract "Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive flavonoid with promising biological activities. This study investigated the hepatoprotective effect of Gal in CP-induced rats. Rats received Gal (15, 30 and 60 mg/kg/day) for 15 days followed by a single dose of CP at day 16. Cyclophosphamide triggered liver injury characterized by elevated serum transaminases, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), and histopathological manifestations. Increased hepatic reactive oxygen species, malondialdehyde, nitric oxide, and oxidative DNA damage along with declined glutathione and antioxidant enzymes were demonstrated in CP-administered rats. CP provoked hepatic nuclear factor-kappaB (NF-κB) phosphorylation and increased mRNA abundance of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) both expression and serum levels. Gal prevented CP-induced liver injury, boosted antioxidants and suppressed oxidative stress, DNA damage, NF-κB phosphorylation and pro-inflammatory mediators. Gal diminished Bax and caspase-3, and increased B-cell lymphoma-2 (Bcl-2) in liver of CP-administered rats. In addition, Gal increased peroxisome proliferator-activated receptor gamma (PPARγ) expression and activated hepatic nuclear factor erythroid 2-related factor 2 (Nrf2) signaling showed by the increase in Nrf2, NAD(P)H: quinone acceptor oxidoreductase-1 (NQO-1) and heme oxygenase 1 (HO-1) in CP-administered rats. These findings suggest that Gal prevents CP hepatotoxicity through activation of Nrf2/HO-1 signaling and attenuation of oxidative damage, inflammation and cell death. Therefore, Gal might represent a promising adjuvant therapy to prevent hepatotoxicity in patients on CP treatment." @default.
• W2964461736 created "2019-08-13" @default.
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• W2964461736 date "2019-08-05" @default.
• W2964461736 modified "2023-10-10" @default.
• W2964461736 title "Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity" @default.
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• W2964461736 cites W1647126819 @default.
• W2964461736 cites W1691027052 @default.
• W2964461736 cites W1977941840 @default.
• W2964461736 cites W1978152747 @default.
• W2964461736 cites W1978475153 @default.
• W2964461736 cites W1989094061 @default.
• W2964461736 cites W1992800757 @default.
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• W2964461736 cites W2006815797 @default.
• W2964461736 cites W2035091931 @default.
• W2964461736 cites W2040998967 @default.
• W2964461736 cites W2045308912 @default.
• W2964461736 cites W2049292753 @default.
• W2964461736 cites W2060903162 @default.
• W2964461736 cites W2062778001 @default.
• W2964461736 cites W2072729440 @default.
• W2964461736 cites W2085608528 @default.
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• W2964461736 cites W2100995755 @default.
• W2964461736 cites W2103329755 @default.
• W2964461736 cites W2105130679 @default.
• W2964461736 cites W2107277218 @default.
• W2964461736 cites W2118519973 @default.
• W2964461736 cites W2122386753 @default.
• W2964461736 cites W2133584350 @default.
• W2964461736 cites W2179079302 @default.
• W2964461736 cites W2192080449 @default.
• W2964461736 cites W2258540270 @default.
• W2964461736 cites W2266929960 @default.
• W2964461736 cites W2307905926 @default.
• W2964461736 cites W2404244235 @default.
• W2964461736 cites W2507638238 @default.
• W2964461736 cites W2546905330 @default.
• W2964461736 cites W2551804260 @default.
• W2964461736 cites W2564778141 @default.
• W2964461736 cites W2566634656 @default.
• W2964461736 cites W2591282736 @default.
• W2964461736 cites W2598681194 @default.
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• W2964461736 cites W2607430615 @default.
• W2964461736 cites W2620500305 @default.
• W2964461736 cites W2727404960 @default.
• W2964461736 cites W2740301936 @default.
• W2964461736 cites W2740982903 @default.
• W2964461736 cites W2748095053 @default.
• W2964461736 cites W2754296049 @default.
• W2964461736 cites W2755606774 @default.
• W2964461736 cites W2766116673 @default.
• W2964461736 cites W2788870748 @default.
• W2964461736 cites W2792279154 @default.
• W2964461736 cites W2792566460 @default.
• W2964461736 cites W2803748090 @default.
• W2964461736 cites W2803818979 @default.
• W2964461736 cites W2843268874 @default.
• W2964461736 cites W2883020204 @default.
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• W2964461736 doi "https://doi.org/10.3390/biom9080346" @default.
• W2964461736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6723184" @default.
• W2964461736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31387329" @default.
• W2964461736 hasPublicationYear "2019" @default.
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