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- W2964483649 abstract "Chromatin accessibility plays a critical factor in regulating gene expression in cancer cells. Several factors, including the High Mobility Group A (HMGA) family members, are known to participate directly in chromatin relaxation and transcriptional activation. The HMGA1 oncogene encodes an architectural chromatin transcription factor that alters DNA structure and interacts with transcription factors favouring their landing onto transcription regulatory sequences. Here, we provide evidence of an additional mechanism exploited by HMGA1 to modulate transcription. We demonstrate that, in a triple-negative breast cancer cellular model, HMGA1 sustains the action of epigenetic modifiers and in particular it positively influences both histone H3S10 phosphorylation by ribosomal protein S6 kinase alpha-3 (RSK2) and histone H2BK5 acetylation by CREB-binding protein (CBP). HMGA1, RSK2, and CBP control the expression of a set of genes involved in tumor progression and epithelial to mesenchymal transition. These results suggest that HMGA1 has an effect on the epigenetic status of cancer cells and that it could be exploited as a responsiveness predictor for epigenetic therapies in triple-negative breast cancers." @default.
- W2964483649 created "2019-08-13" @default.
- W2964483649 creator A5002415307 @default.
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- W2964483649 creator A5071139479 @default.
- W2964483649 date "2019-08-02" @default.
- W2964483649 modified "2023-10-13" @default.
- W2964483649 title "HMGA1 Modulates Gene Transcription Sustaining a Tumor Signalling Pathway Acting on the Epigenetic Status of Triple-Negative Breast Cancer Cells" @default.
- W2964483649 cites W143049927 @default.
- W2964483649 cites W1562436834 @default.
- W2964483649 cites W1591323475 @default.
- W2964483649 cites W1642603977 @default.
- W2964483649 cites W1832186116 @default.
- W2964483649 cites W1858703699 @default.
- W2964483649 cites W1900657670 @default.
- W2964483649 cites W1927950101 @default.
- W2964483649 cites W1938875781 @default.
- W2964483649 cites W1967600634 @default.
- W2964483649 cites W1968590253 @default.
- W2964483649 cites W1973289524 @default.
- W2964483649 cites W1973704051 @default.
- W2964483649 cites W1974761743 @default.
- W2964483649 cites W1975014056 @default.
- W2964483649 cites W1979953062 @default.
- W2964483649 cites W1982776595 @default.
- W2964483649 cites W1983861034 @default.
- W2964483649 cites W1983979223 @default.
- W2964483649 cites W1985063313 @default.
- W2964483649 cites W1990636453 @default.
- W2964483649 cites W1991786443 @default.
- W2964483649 cites W1995182112 @default.
- W2964483649 cites W1995256948 @default.
- W2964483649 cites W1999372538 @default.
- W2964483649 cites W2007558412 @default.
- W2964483649 cites W2017311565 @default.
- W2964483649 cites W2017370430 @default.
- W2964483649 cites W2017622605 @default.
- W2964483649 cites W2025851625 @default.
- W2964483649 cites W2026671371 @default.
- W2964483649 cites W2027425960 @default.
- W2964483649 cites W2029733458 @default.
- W2964483649 cites W2030183122 @default.
- W2964483649 cites W2040803819 @default.
- W2964483649 cites W2042715516 @default.
- W2964483649 cites W2044270602 @default.
- W2964483649 cites W2048537883 @default.
- W2964483649 cites W2052615604 @default.
- W2964483649 cites W2058680737 @default.
- W2964483649 cites W2066607735 @default.
- W2964483649 cites W2071427251 @default.
- W2964483649 cites W2071551902 @default.
- W2964483649 cites W2076132501 @default.
- W2964483649 cites W2079879959 @default.
- W2964483649 cites W2082163698 @default.
- W2964483649 cites W2082541706 @default.
- W2964483649 cites W2086262311 @default.
- W2964483649 cites W2086310768 @default.
- W2964483649 cites W2088134192 @default.
- W2964483649 cites W2088733561 @default.
- W2964483649 cites W2095237894 @default.
- W2964483649 cites W2095512976 @default.
- W2964483649 cites W2098155709 @default.
- W2964483649 cites W2105437003 @default.
- W2964483649 cites W2106461424 @default.
- W2964483649 cites W2107558077 @default.
- W2964483649 cites W2108564378 @default.
- W2964483649 cites W2110493973 @default.
- W2964483649 cites W2116131625 @default.
- W2964483649 cites W2117692326 @default.
- W2964483649 cites W2118722680 @default.
- W2964483649 cites W2119987781 @default.
- W2964483649 cites W2120320431 @default.
- W2964483649 cites W2123663533 @default.
- W2964483649 cites W2126929638 @default.
- W2964483649 cites W2128903974 @default.
- W2964483649 cites W2128998793 @default.
- W2964483649 cites W2134094791 @default.
- W2964483649 cites W2134406847 @default.
- W2964483649 cites W2134801815 @default.
- W2964483649 cites W2139780207 @default.
- W2964483649 cites W2142830339 @default.
- W2964483649 cites W2143658931 @default.
- W2964483649 cites W2147510335 @default.
- W2964483649 cites W2148043102 @default.
- W2964483649 cites W2149407896 @default.
- W2964483649 cites W2150585673 @default.
- W2964483649 cites W2162917230 @default.
- W2964483649 cites W2165176539 @default.
- W2964483649 cites W2165798632 @default.
- W2964483649 cites W2165894156 @default.
- W2964483649 cites W2167758528 @default.
- W2964483649 cites W2169947232 @default.