Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964496562> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2964496562 abstract "Efficiency is a perennial motivation of statistical analysis and clinical trials. This is most pertinent when sample size is constrained. When trials and their analyses are more efficient, results can be more precise, can be disseminated quicker, and impact the clinical pathway faster.This thesis describes methods developed and investigated by the author in three trials at the Cancer Research UK Clinical Trials Unit. Methods for seamless phase I/II trials that conduct dose-finding by efficacy and toxicity outcomes are studied. A repeated measures analysis in an ultra-rare disease yields a feasible trial where standard approaches do not. Finally, this thesis develops methods for a phase II trial with co-primary outcomes and predictive covariate information. We conclude that two common goals to increase efficiency are: i) use more outcomes to answer trial questions; and ii) use all available information. In our examples, analysing efficacy and toxicity in dose-finding lets these trials simultaneously achieve phase I and II objectives. However, this thesis highlights operational issues that can impair efficiency. We show that statistical performance is improved by analysing the information in repeated measures and predictive baseline covariates. Methods developed herein help to achieve conventional error rates without prohibitive increases in sample size." @default.
- W2964496562 created "2019-08-13" @default.
- W2964496562 creator A5019472985 @default.
- W2964496562 date "2019-07-17" @default.
- W2964496562 modified "2023-09-27" @default.
- W2964496562 title "Methods to increase efficiency in clinical trials with restricted sample size" @default.
- W2964496562 hasPublicationYear "2019" @default.
- W2964496562 type Work @default.
- W2964496562 sameAs 2964496562 @default.
- W2964496562 citedByCount "1" @default.
- W2964496562 countsByYear W29644965622019 @default.
- W2964496562 crossrefType "dissertation" @default.
- W2964496562 hasAuthorship W2964496562A5019472985 @default.
- W2964496562 hasConcept C105795698 @default.
- W2964496562 hasConcept C119043178 @default.
- W2964496562 hasConcept C119857082 @default.
- W2964496562 hasConcept C126322002 @default.
- W2964496562 hasConcept C129848803 @default.
- W2964496562 hasConcept C185592680 @default.
- W2964496562 hasConcept C198531522 @default.
- W2964496562 hasConcept C33923547 @default.
- W2964496562 hasConcept C41008148 @default.
- W2964496562 hasConcept C43617362 @default.
- W2964496562 hasConcept C535046627 @default.
- W2964496562 hasConcept C71924100 @default.
- W2964496562 hasConceptScore W2964496562C105795698 @default.
- W2964496562 hasConceptScore W2964496562C119043178 @default.
- W2964496562 hasConceptScore W2964496562C119857082 @default.
- W2964496562 hasConceptScore W2964496562C126322002 @default.
- W2964496562 hasConceptScore W2964496562C129848803 @default.
- W2964496562 hasConceptScore W2964496562C185592680 @default.
- W2964496562 hasConceptScore W2964496562C198531522 @default.
- W2964496562 hasConceptScore W2964496562C33923547 @default.
- W2964496562 hasConceptScore W2964496562C41008148 @default.
- W2964496562 hasConceptScore W2964496562C43617362 @default.
- W2964496562 hasConceptScore W2964496562C535046627 @default.
- W2964496562 hasConceptScore W2964496562C71924100 @default.
- W2964496562 hasLocation W29644965621 @default.
- W2964496562 hasOpenAccess W2964496562 @default.
- W2964496562 hasPrimaryLocation W29644965621 @default.
- W2964496562 hasRelatedWork W168601764 @default.
- W2964496562 hasRelatedWork W1989266740 @default.
- W2964496562 hasRelatedWork W2013337297 @default.
- W2964496562 hasRelatedWork W2020526475 @default.
- W2964496562 hasRelatedWork W2024922049 @default.
- W2964496562 hasRelatedWork W2040478536 @default.
- W2964496562 hasRelatedWork W2151523134 @default.
- W2964496562 hasRelatedWork W2295064511 @default.
- W2964496562 hasRelatedWork W2320102051 @default.
- W2964496562 hasRelatedWork W2681243854 @default.
- W2964496562 hasRelatedWork W2758592311 @default.
- W2964496562 hasRelatedWork W2800095466 @default.
- W2964496562 hasRelatedWork W2886292011 @default.
- W2964496562 hasRelatedWork W2920777501 @default.
- W2964496562 hasRelatedWork W2941684867 @default.
- W2964496562 hasRelatedWork W2950465608 @default.
- W2964496562 hasRelatedWork W2988869061 @default.
- W2964496562 hasRelatedWork W3081598744 @default.
- W2964496562 hasRelatedWork W3162208188 @default.
- W2964496562 hasRelatedWork W3200560976 @default.
- W2964496562 isParatext "false" @default.
- W2964496562 isRetracted "false" @default.
- W2964496562 magId "2964496562" @default.
- W2964496562 workType "dissertation" @default.