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• W2964507669 endingPage "3211" @default.
• W2964507669 startingPage "3201" @default.
• W2964507669 abstract "Abstract Meiotic crossing over ensures proper segregation of homologous chromosomes and generates genotypic diversity. Despite these functions, little is known about the genetic factors and population genetic forces involved in the evolution of recombination rate differences among species. The dicistronic meiosis gene, mei-217/mei-218, mediates most of the species differences in crossover rate and patterning during female meiosis between the closely related fruitfly species, Drosophila melanogaster and D. mauritiana. The MEI-218 protein is one of several meiosis-specific mini-chromosome maintenance (mei-MCM) proteins that form a multi-protein complex essential to crossover formation, whereas the BLM helicase acts as an anti-crossover protein. Here we study the molecular evolution of five genes— mei-218, the other three known members of the mei-MCM complex, and Blm— over the phylogenies of three Drosophila species groups— melanogaster, obscura, and virilis. We then use transgenic assays in D. melanogaster to test if molecular evolution at mei-218 has functional consequences for crossing over using alleles from the distantly related species D. pseudoobscura and D. virilis. Our molecular evolutionary analyses reveal recurrent positive selection at two mei-MCM genes. Our transgenic assays show that sequence divergence among mei-218 alleles from D. melanogaster, D. pseudoobscura, and D. virilis has functional consequences for crossing over. In a D. melanogaster genetic background, the D. pseudoobscura mei-218 allele nearly rescues wildtype crossover rates but alters crossover patterning, whereas the D. virilis mei-218 allele conversely rescues wildtype crossover patterning but not crossover rates. These experiments demonstrate functional divergence at mei-218 and suggest that crossover rate and patterning are separable functions." @default.
• W2964507669 created "2019-08-13" @default.
• W2964507669 creator A5009042053 @default.
• W2964507669 creator A5055820479 @default.
• W2964507669 creator A5060215573 @default.
• W2964507669 date "2019-10-01" @default.
• W2964507669 modified "2023-10-11" @default.
• W2964507669 title "Positive Selection and Functional Divergence at Meiosis Genes That Mediate Crossing Over Across the<i>Drosophila</i>Phylogeny" @default.
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• W2964507669 doi "https://doi.org/10.1534/g3.119.400280" @default.
• W2964507669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6778797" @default.
• W2964507669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31362974" @default.
• W2964507669 hasPublicationYear "2019" @default.
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