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- W2964572009 abstract "Abstract Background and objective To identify early, non-invasive prognostic indicators in heart failure (HF), with and without associated pulmonary hypertension, by means of cardiac magnetic resonance, and oxidative stress and anti-inflammatory biomarkers such as Trolox™ (antioxidant status) and IL-10 (anti-inflammatory cytokine). Patients and methods We prospectively included 70 patients admitted for new-onset HF. During index admission, mean velocity of the pulmonary artery (mvPA) was measured, and blood Trolox™ and IL-10 determined. The study sample was divided in two groups according to the optimal cut-off value for event prediction calculated by the ROC curve (mvPA = 8 cm/s), considering HF-readmission and all-cause mortality as the primary combined event. Results During a median follow-up of 290 days, 16 events occurred. In patients with preserved right ventricular (RV) function, mvPA ≤8 cm/s was associated with a higher incidence of events during follow-up, Kaplan–Meier survival analysis (log rank 6.01, p = 0.014). MvPA did not add prognostic value when RV dysfunction was already established. Trolox™ concentration was lower in patients with mvPA ≤8 cm/s. Higher IL-10 expression was associated with a lower incidence of cardiovascular events during follow-up. Conclusion In HF patients, mvPA ≤8 cm/s predicts a higher rate of cardiovascular events. Specifically, mvPA identifies a higher risk population among patients with preserved RV function, thus confirming its role as an early prognostic indicator. Lower Trolox™ concentration in the worse prognosis group concurs with previous studies on oxidative stress in pulmonary hypertension. Higher IL-10 concentration among patients free of cardiovascular events could be a reflection of its anti-inflammatory and thus protective role in HF." @default.
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- W2964572009 date "2019-09-01" @default.
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- W2964572009 title "Mean velocity of the pulmonary artery estimated by cardiac magnetic resonance as an early prognostic predictor in heart failure" @default.
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- W2964572009 doi "https://doi.org/10.1016/j.medcle.2019.07.004" @default.
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