Matches in SemOpenAlex for { <https://semopenalex.org/work/W296460680> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W296460680 endingPage "9" @default.
- W296460680 startingPage "6" @default.
- W296460680 abstract "目的探讨乌司他丁对Caspase-3、Caspase-8活性和Bcl-2表达的影响，了解肝细胞凋亡与急性肝衰竭的关系以及乌司他丁对其预后影响。方法雄性SD大鼠96只，随机分为对照组，模型组和UTI处理组，模型组和UTI处理组再分为6、12、24、36、48取材5组。另模型组和UTI处理组中各取15只大鼠观察生存率和生存时间。腹腔内注射D—GalN／LPS建立大鼠急性肝衰竭模型，UTI处理组则在腹腔内注射D—GalN／LPS后立即注射UTI，模型组则在腹腔内注射D—GalN／LPS后立即注射0．4mL生理盐水。正常对照组则腹腔注射2mL生理盐水。在相应时间点处死各组大鼠，检测血生化指标AST、ALT等，HE染色观察肝脏病理形态学变化，ELISA法检测TNF-a，取肝组织匀浆检测Caspase-3和Caspase-8活性，免疫组化法检测Bcl-2在肝组织中的表达。结果UTI处理组较模型组大鼠生存率有显著性提高，生化指标明显好转，病理检查也发现肝坏死程度和范围明显减轻，血清TNF-a水平明显降低，Caspase-3和Caspase-8活性明显降低，而Bcl-2表达明显增加。结论乌司他丁能提高急性肝衰竭大鼠的生存率，其机制可能与降低急性肝衰竭大鼠血清TNF-a水平，降低肝组织Cas—pase-3和Caspase-8活性，增加抗凋亡蛋白Bcl-2的表达有关。" @default.
- W296460680 created "2016-06-24" @default.
- W296460680 creator A5045106792 @default.
- W296460680 creator A5065448686 @default.
- W296460680 date "2011-01-01" @default.
- W296460680 modified "2023-09-24" @default.
- W296460680 title "乌司他丁对GalN／LPS引起大鼠急性肝衰竭Caspase-3、Caspase-8和Bcl-2的影响" @default.
- W296460680 hasPublicationYear "2011" @default.
- W296460680 type Work @default.
- W296460680 sameAs 296460680 @default.
- W296460680 citedByCount "0" @default.
- W296460680 crossrefType "journal-article" @default.
- W296460680 hasAuthorship W296460680A5045106792 @default.
- W296460680 hasAuthorship W296460680A5065448686 @default.
- W296460680 hasConcept C1186008 @default.
- W296460680 hasConcept C12519072 @default.
- W296460680 hasConcept C185592680 @default.
- W296460680 hasConcept C190283241 @default.
- W296460680 hasConcept C2775998712 @default.
- W296460680 hasConcept C31573885 @default.
- W296460680 hasConcept C48297814 @default.
- W296460680 hasConcept C55493867 @default.
- W296460680 hasConcept C86803240 @default.
- W296460680 hasConcept C91096171 @default.
- W296460680 hasConcept C95444343 @default.
- W296460680 hasConcept C98424977 @default.
- W296460680 hasConceptScore W296460680C1186008 @default.
- W296460680 hasConceptScore W296460680C12519072 @default.
- W296460680 hasConceptScore W296460680C185592680 @default.
- W296460680 hasConceptScore W296460680C190283241 @default.
- W296460680 hasConceptScore W296460680C2775998712 @default.
- W296460680 hasConceptScore W296460680C31573885 @default.
- W296460680 hasConceptScore W296460680C48297814 @default.
- W296460680 hasConceptScore W296460680C55493867 @default.
- W296460680 hasConceptScore W296460680C86803240 @default.
- W296460680 hasConceptScore W296460680C91096171 @default.
- W296460680 hasConceptScore W296460680C95444343 @default.
- W296460680 hasConceptScore W296460680C98424977 @default.
- W296460680 hasIssue "4" @default.
- W296460680 hasLocation W2964606801 @default.
- W296460680 hasOpenAccess W296460680 @default.
- W296460680 hasPrimaryLocation W2964606801 @default.
- W296460680 hasVolume "49" @default.
- W296460680 isParatext "false" @default.
- W296460680 isRetracted "false" @default.
- W296460680 magId "296460680" @default.
- W296460680 workType "article" @default.