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- W2964669794 abstract "Summary Integrative and conjugative elements (ICEs) are mobile genetic elements that transfer from cell to cell by conjugation (like plasmids) and integrate into the chromosomes of bacterial hosts (like lysogenic phages or transposons). ICEs are prevalent in bacterial chromosomes and play a major role in bacterial evolution by promoting horizontal gene transfer. Exclusion prevents the redundant transfer of conjugative elements into host cells that already contain a copy of the element. Exclusion has been characterized mostly for conjugative elements of Gram‐negative bacteria. Here, we report the identification and characterization of an exclusion mechanism in ICE Bs1 from the Gram‐positive bacterium Bacillus subtilis . We found that cells containing ICE Bs1 inhibit the activity of the ICE Bs1 ‐encoded conjugation machinery in other cells. This inhibition (exclusion) was specific to the cognate conjugation machinery and the ICE Bs1 gene yddJ was both necessary and sufficient to mediate exclusion by recipient cells. Through a mutagenesis and enrichment screen, we identified exclusion‐resistant mutations in the ICE Bs1 gene conG . Using genes from a heterologous but related ICE, we found that the exclusion specificity was determined by ConG and YddJ. Finally, we found that under conditions that support conjugation, exclusion provides a selective advantage to the element and its host cells." @default.
- W2964669794 created "2019-08-13" @default.
- W2964669794 creator A5013830173 @default.
- W2964669794 creator A5056293755 @default.
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- W2964669794 date "2019-08-16" @default.
- W2964669794 modified "2023-10-16" @default.
- W2964669794 title "Identification, characterization and benefits of an exclusion system in an integrative and conjugative element of<i>Bacillus subtilis</i>" @default.
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- W2964669794 doi "https://doi.org/10.1111/mmi.14359" @default.
- W2964669794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6827876" @default.
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- W2964669794 hasPublicationYear "2019" @default.
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