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- W2964683003 abstract "Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between them is still unknown. In this paper, we analyzed how these two diseases relate to each other from the genomic, epigenomic, and transcriptomic viewpoints. Using an extensive literature mining, we first accumulated the list of genes from major genome-wide association (GWAS) studies. Based on these GWAS studies, we observed that only one gene (HLA-DRB5) was shared between AD and PD. A subsequent literature search identified a few other genes involved in these two diseases, among which SIRT1 seemed to be the most prominent one. While we listed all the miRNAs that have been previously reported for AD and PD separately, we found only 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene co-expression network for both AD and PD using network analysis algorithms applied to two GEO datasets. The network analysis revealed six clusters of genes related to AD and four clusters of genes related to PD; however, there was very low functional similarity between these clusters, pointing to insignificant similarity between AD and PD even at the level of affected biological processes. Finally, we postulated the putative epigenetic regulator modules that are common to AD and PD." @default.
- W2964683003 created "2019-08-13" @default.
- W2964683003 creator A5018203536 @default.
- W2964683003 creator A5029609822 @default.
- W2964683003 creator A5050819040 @default.
- W2964683003 creator A5051020073 @default.
- W2964683003 creator A5069429361 @default.
- W2964683003 creator A5073361185 @default.
- W2964683003 creator A5076978229 @default.
- W2964683003 creator A5080886331 @default.
- W2964683003 date "2019-07-30" @default.
- W2964683003 modified "2023-10-06" @default.
- W2964683003 title "Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases" @default.
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