FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964683205> ?p ?o ?g. }

• W2964683205 endingPage "1623" @default.
• W2964683205 startingPage "1617" @default.
• W2964683205 abstract "Background Data indicate that codispensing flucloxacillin to patients already on warfarin may result in decreased warfarin efficacy. Objectives This article investigates the effect of flucloxacillin on warfarin anticoagulation. Patients and Methods In a retrospective cohort study of warfarin users, using three nationwide registers we included 5,848 patients receiving 10 days flucloxacillin treatment and 201 with ≥30 days treatment. To assess the potential for confounding by indication, we also identified 21,430 individuals initiating phenoxymethylpenicillin. International normalized ratio (INR) values and warfarin doses were calculated day-by-day and proportion of patients with a subtherapeutic INR week-by-week during cotreatment. Results Following initiation of flucloxacillin with a planned treatment duration of 10 days and ≥30 days, the mean INR decreased from 2.36 (95% confidence interval [CI] 2.34; 2.37) to 2.20 (95% CI 2.19; 2.21) and from 2.24 (95% CI 2.16; 2.32) to 1.96 (95% CI 1.89; 2.02), respectively. Consequently, for individuals with 10 days treatment the proportion of patients with a subtherapeutic INR of < 2 increased from 22% in the week preceding flucloxacillin initiation to 35% in the third week after initiation of flucloxacillin. In patients with 30 days treatment, the proportion increased from 34 to 63% by week 6. In individuals initiating phenoxymethylpenicillin, INR levels did not decrease. Conclusion One in three patients with 10 days flucloxacillin and almost two in three patients initiating long-term treatment, was exposed to a subsequent subtherapeutic anticoagulant effect. To avoid unnecessary thromboembolic complications, the initiation of flucloxacillin should be accompanied by closer INR monitoring which may be especially important among individuals with lengthy treatments." @default.
• W2964683205 created "2019-08-13" @default.
• W2964683205 creator A5005287400 @default.
• W2964683205 creator A5065073643 @default.
• W2964683205 creator A5072859924 @default.
• W2964683205 creator A5087188275 @default.
• W2964683205 date "2019-07-28" @default.
• W2964683205 modified "2023-10-02" @default.
• W2964683205 title "The Effect of Flucloxacillin on Warfarin Anticoagulation: A Swedish Register-Based Nationwide Cohort Study" @default.
• W2964683205 cites W1586488555 @default.
• W2964683205 cites W1599481453 @default.
• W2964683205 cites W1986432711 @default.
• W2964683205 cites W2005876531 @default.
• W2964683205 cites W2012052609 @default.
• W2964683205 cites W2042138855 @default.
• W2964683205 cites W2047731840 @default.
• W2964683205 cites W2089534375 @default.
• W2964683205 cites W2097896189 @default.
• W2964683205 cites W2100036144 @default.
• W2964683205 cites W2156687558 @default.
• W2964683205 cites W2168021466 @default.
• W2964683205 cites W2269923173 @default.
• W2964683205 cites W2305885255 @default.
• W2964683205 cites W2337046207 @default.
• W2964683205 cites W2548706052 @default.
• W2964683205 cites W2557916595 @default.
• W2964683205 cites W2765589989 @default.
• W2964683205 cites W2786978014 @default.
• W2964683205 doi "https://doi.org/10.1055/s-0039-1693462" @default.
• W2964683205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31352678" @default.
• W2964683205 hasPublicationYear "2019" @default.
• W2964683205 type Work @default.
• W2964683205 sameAs 2964683205 @default.
• W2964683205 citedByCount "5" @default.
• W2964683205 countsByYear W29646832052019 @default.
• W2964683205 countsByYear W29646832052022 @default.
• W2964683205 countsByYear W29646832052023 @default.
• W2964683205 crossrefType "journal-article" @default.
• W2964683205 hasAuthorship W2964683205A5005287400 @default.
• W2964683205 hasAuthorship W2964683205A5065073643 @default.
• W2964683205 hasAuthorship W2964683205A5072859924 @default.
• W2964683205 hasAuthorship W2964683205A5087188275 @default.
• W2964683205 hasConcept C126322002 @default.
• W2964683205 hasConcept C141071460 @default.
• W2964683205 hasConcept C167135981 @default.
• W2964683205 hasConcept C201903717 @default.
• W2964683205 hasConcept C2776301958 @default.
• W2964683205 hasConcept C2778205648 @default.
• W2964683205 hasConcept C2778355172 @default.
• W2964683205 hasConcept C2779161974 @default.
• W2964683205 hasConcept C2779489039 @default.
• W2964683205 hasConcept C44249647 @default.
• W2964683205 hasConcept C523546767 @default.
• W2964683205 hasConcept C54355233 @default.
• W2964683205 hasConcept C71924100 @default.
• W2964683205 hasConcept C72563966 @default.
• W2964683205 hasConcept C86803240 @default.
• W2964683205 hasConceptScore W2964683205C126322002 @default.
• W2964683205 hasConceptScore W2964683205C141071460 @default.
• W2964683205 hasConceptScore W2964683205C167135981 @default.
• W2964683205 hasConceptScore W2964683205C201903717 @default.
• W2964683205 hasConceptScore W2964683205C2776301958 @default.
• W2964683205 hasConceptScore W2964683205C2778205648 @default.
• W2964683205 hasConceptScore W2964683205C2778355172 @default.
• W2964683205 hasConceptScore W2964683205C2779161974 @default.
• W2964683205 hasConceptScore W2964683205C2779489039 @default.
• W2964683205 hasConceptScore W2964683205C44249647 @default.
• W2964683205 hasConceptScore W2964683205C523546767 @default.
• W2964683205 hasConceptScore W2964683205C54355233 @default.
• W2964683205 hasConceptScore W2964683205C71924100 @default.
• W2964683205 hasConceptScore W2964683205C72563966 @default.
• W2964683205 hasConceptScore W2964683205C86803240 @default.
• W2964683205 hasIssue "10" @default.
• W2964683205 hasLocation W29646832051 @default.
• W2964683205 hasLocation W29646832052 @default.
• W2964683205 hasOpenAccess W2964683205 @default.
• W2964683205 hasPrimaryLocation W29646832051 @default.
• W2964683205 hasRelatedWork W1971557041 @default.
• W2964683205 hasRelatedWork W2020878612 @default.
• W2964683205 hasRelatedWork W2157077459 @default.
• W2964683205 hasRelatedWork W2273462689 @default.
• W2964683205 hasRelatedWork W2588872680 @default.
• W2964683205 hasRelatedWork W2754539770 @default.
• W2964683205 hasRelatedWork W2937211356 @default.
• W2964683205 hasRelatedWork W2964683205 @default.
• W2964683205 hasRelatedWork W3035286185 @default.
• W2964683205 hasRelatedWork W4312780918 @default.
• W2964683205 hasVolume "119" @default.
• W2964683205 isParatext "false" @default.
• W2964683205 isRetracted "false" @default.
• W2964683205 magId "2964683205" @default.
• W2964683205 workType "article" @default.