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• W2964696124 abstract "BackgroundRecent work suggests that the function of intracortical interneurons activated by transcranial magnetic stimulation (TMS) is modified in older adults, with the circuits generating short-interval intracortical facilitation (SICF) at longer intervals appearing to be particularly affected.ObjectiveTo use SICF to quantify age-related changes in the excitability and recruitment of late synaptic inputs to corticospinal neurons, and investigate if changes within these circuits contribute to altered motor performance in older adults.MethodsSICF was recorded with 3 different conditioning intensities in 23 young (23.0 ± 4.2 years) and 21 older (67.1 ± 1.1 years) adults. These measures were performed with conventional (posterior-anterior, PA) and reverse (anterior-posterior, AP) current directions using interstimulus intervals targeting late synaptic inputs to corticospinal neurons (3.5–5.3 ms).ResultsPeak SICF recorded with a PA current (SICFPA) was reduced in older adults (P < 0.0001), and occurred at a longer latency (P < 0.05). Furthermore, there was reduced recruitment of SICFPA in older adults (P < 0.0001), but this did not interact with the age-related shift in SICFPA (P = 0.2). In addition, reduced performance on the Purdue pegboard was predicted by increased SICFPA (P < 0.04) occurring at longer latencies (P < 0.04) in old but not young adults. For SICF recorded with an AP current (SICFAP), facilitation was again reduced at longer latencies in older adults (P < 0.0001), but recruitment was not different between groups (P = 0.7) and was unrelated to motor function.ConclusionThese results suggest that there are age-related changes in late synaptic inputs to corticospinal neurons and that these changes influence fine motor performance." @default.
• W2964696124 created "2019-08-13" @default.
• W2964696124 creator A5018089972 @default.
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• W2964696124 date "2020-01-01" @default.
• W2964696124 modified "2023-10-09" @default.
• W2964696124 title "Age-related changes in late synaptic inputs to corticospinal neurons and their functional significance: A paired-pulse TMS study" @default.
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• W2964696124 doi "https://doi.org/10.1016/j.brs.2019.08.003" @default.
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