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• W2964696980 abstract "Annexins constitute a family of calcium-dependent membrane-binding proteins and can be classified into two groups, depending on the length of the N-terminal domain unique for each individual annexin. The N-terminal domain of annexin A1 can adopt an a-helical conformation and has been implicated in mediating the membrane aggregation behavior of this protein. Although the calcium-independent interaction of the annexin A1 N-terminal domain has been known for some time, there was no structural information about the membrane interaction of this secondary membrane-binding site of annexin A1. This study used circular dichroism spectroscopy to show that a rat annexin A1 N-terminal peptide possesses random coil structure in aqueous buffer but ana-helical structure in the presence of small unilamellar vesicles. The binding of peptides tomembraneswas confirmed by surface pressure (Langmuir film balance) measurements using phosphatidylcholine/phosphatidylserine monolayers, which show a significant increase after injection of rat annexin A1 N-terminal peptides. Lamellar neutron diffraction with human and rat annexinA1N-terminal peptides reveals an intercalation of the helical peptideswith the phospholipid bilayer, with the helix axis lying parallel to the surface of membrane. Our findings confirm that phospholipid membranes assist the folding of the N-terminal peptides into a-helical structures and that this conformation enables favorable direct interactions with the membrane. The results are consistentwith the hypothesis that theN-terminal domain of annexinA1 can serve as a secondarymembranebinding site in the process of membrane aggregation by providing a peripheral membrane anchor." @default.
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• W2964696980 date "2016-01-01" @default.
• W2964696980 modified "2023-09-23" @default.
• W2964696980 title "Membrane-Induced Folding and Structure of Membrane-Bound Annexin A1 N-Terminal Peptides" @default.
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