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- W2964707918 abstract "In rheumatoid arthritis (RA), various hematopoietic and non-hematopoietic cells present in the synovial tissue secrete numerous inflammatory mediators including pro-inflammatory cytokines critical for the induction of chronic joint inflammation and bone destruction. Fibroblast-like synoviocytes (FLSs) in the non-hematopoietic cell compartment are key inflammatory cells activated in inflamed joints and driving the disease; yet how synovial tissue inflammation is modulated by autoimmune T cells is not fully understood. In this review, mainly based on recent findings with a mouse model of spontaneous autoimmune arthritis, we discuss the mechanism of Th17-mediated synovial tissue inflammation; that is, what environmental stimuli and arthritogenic self-antigens trigger arthritis, how arthritogenic T cells initiate joint inflammation by stimulating FLSs, and how the cellular sources of GM-CSF from lymphoid and tissue stromal cells in the synovium contribute to the development of arthritis. We also highlight possible plasticity of Th17 cells toward pathogenic GM-CSF producers, and the functional instability of regulatory T cells under inflammatory conditions in RA joints." @default.
- W2964707918 created "2019-08-13" @default.
- W2964707918 creator A5022366571 @default.
- W2964707918 creator A5025764166 @default.
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- W2964707918 date "2019-08-21" @default.
- W2964707918 modified "2023-10-14" @default.
- W2964707918 title "Synovial Tissue Inflammation Mediated by Autoimmune T Cells" @default.
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- W2964707918 doi "https://doi.org/10.3389/fimmu.2019.01989" @default.
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