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• W2964731129 endingPage "3006" @default.
• W2964731129 startingPage "3006" @default.
• W2964731129 abstract "DNA nanotechnology offers the possibility to rationally design structures with emergent properties by precisely controlling their geometry and functionality. Here, we demonstrate a DNA-based plasmonic metamolecule that is capable of sensing human thrombin proteins. The chiral reconfigurability of a DNA origami structure carrying two gold nanorods was used to provide optical read-out of thrombin binding through changes in the displayed plasmonic circular dichroism. In our experiments, each arm of the structure was modified with one of two different thrombin-binding aptamers—thrombin-binding aptamer (TBA) and HD22—in such a way that a thrombin molecule could be sandwiched by the aptamers to lock the metamolecule in a state of defined chirality. Our structure exhibited a Kd of 1.4 nM, which was an order of magnitude lower than those of the individual aptamers. The increased sensitivity arose from the avidity gained by the cooperative binding of the two aptamers, which was also reflected by a Hill coefficient of 1.3 ± 0.3. As we further exploited the strong plasmonic circular dichroism (CD) signals of the metamolecule, our method allowed one-step, high sensitivity optical detection of human thrombin proteins in solution." @default.
• W2964731129 created "2019-08-13" @default.
• W2964731129 creator A5046044920 @default.
• W2964731129 creator A5046383196 @default.
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• W2964731129 date "2019-07-26" @default.
• W2964731129 modified "2023-09-26" @default.
• W2964731129 title "Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing" @default.
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• W2964731129 doi "https://doi.org/10.3390/app9153006" @default.
• W2964731129 hasPublicationYear "2019" @default.
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