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• W2964732368 abstract "The current study has been carried out at the department of pharmaceutical chemistry, College of pharmacy. Novel synthetically selenium-containing compounds have potential therapeutic effects towards several diseases, such as: cancer microbial infections and neurodegenerative diseases. Therefore, the present study accentuated mainly on two significant items. A novel selenadiazole derivative i.e, 4', 4- (4, 5, 6, 7-TETRAHYDRO- [1, 2, 3-] SELENADIAZOLO [4, 5e] PYRIDINE-4, 6-DIYL) BIS (BENZENE-1, 3-DIOL) (T) and Dipyrone (Di) were used to detretmine their Biochemical effects on female rats. Biochemical test including; liver function tests; Renal functions tests; in addition lipid profile. Invivo study conducted using four groups, one as control (DW) and three treated groups (T, Di, and TD Aspartate aminotransferase levels(AST) measurement it was cleared that only (TD however there was significant decreased of T group VLDL level (20.03mg/dL±1.8) compare with Di (43.4mg/dL±4.3) and T&Di (35.9mg/dL±3.7) levels. Renal function data reveals significant reduction in blood urea levels of (T) (5.471 mg/dL ±3.745) and (T&Di) (10.633±5.431). Serum uric acid values showed significant decline of (T) group (2.601±0.743) than DW group (5.515±2.046). Also, the results of the present study illustrate only Di treated group (2.33±0.209) had essential increased of Creatinine values than all other study groups. The study concluded that synthesized novel selenadiazole derivative, and Dipyrone have mild effects on liver, kidney, and lipid profile. However, the companion of both drugs has some of undesirable effects." @default.
• W2964732368 created "2019-08-13" @default.
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• W2964732368 date "2019-07-01" @default.
• W2964732368 modified "2023-09-23" @default.
• W2964732368 title "Comparative evaluation of biochemical profiling of 4’, 4”- (4, 5, 6, 7-TETRAHYDRO- [1, 2, 3-] SELENADIAZOLO [4, 5e] PYRIDINE-4, 6-DIYL) BIS (BENZENE-1, 3-DIOL) and dipyrone on female rat’s" @default.
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• W2964732368 doi "https://doi.org/10.1088/1742-6596/1279/1/012033" @default.
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