FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964742454> ?p ?o ?g. }

• W2964742454 endingPage "8" @default.
• W2964742454 startingPage "1" @default.
• W2964742454 abstract "Previous studies have established the efficacy of irradiated cancer cells overexpressing GM-CSF or IL-21 as a vaccine. Here we examined whether the vaccine efficacy was greater when both factors were overexpressed together. MB49 bladder cancer cells were transfected with expression plasmid pT7TS encoding mouse GM-CSF and human IL-21, and then irradiated with 100 Gy at 4 days later. The cells (1×10 7 per animal) were injected subcutaneously into C57BL/6 mice at 0, 4, 8, and 12 days after inoculation with MB49 tumor xenografts. Control animals were injected with MB49 cells transfected with pT7TS encoding GM-CSF or IL-21 on its own. Tumor growth was monitored for 45 days and compared among the groups using repeated-measures ANOVA. Vaccination with irradiated MB49 cells did not affect xenograft growth. Vaccination with irradiated cells overexpressing GM-CSF or IL-21 alone significantly inhibited tumor growth and led to significantly more CD4 + CD8 + T cells and fewer CD4 + Foxp3 + T cells in the spleen and xenograft. These effects were even greater following vaccination with irradiated cells overexpressing both GM-CSF and IL-21. Irradiated bladder cancer cells overexpressing both GM-CSF and IL-21 are more effective than cells expressing either factor alone as a vaccine against bladder cancer." @default.
• W2964742454 created "2019-08-13" @default.
• W2964742454 creator A5001005210 @default.
• W2964742454 creator A5016118801 @default.
• W2964742454 creator A5050844331 @default.
• W2964742454 creator A5072133263 @default.
• W2964742454 creator A5078964826 @default.
• W2964742454 creator A5086326013 @default.
• W2964742454 creator A5090292384 @default.
• W2964742454 date "2019-08-05" @default.
• W2964742454 modified "2023-10-16" @default.
• W2964742454 title "Irradiated Bladder Cancer Cells Expressing both GM-CSF and IL-21 versus Either GM-CSF or IL-21 Alone as Tumor Vaccine in a Mouse Xenograft Model" @default.
• W2964742454 cites W1946955186 @default.
• W2964742454 cites W1963595165 @default.
• W2964742454 cites W1982832618 @default.
• W2964742454 cites W1983093014 @default.
• W2964742454 cites W2071183770 @default.
• W2964742454 cites W2078955598 @default.
• W2964742454 cites W2079045913 @default.
• W2964742454 cites W2087979291 @default.
• W2964742454 cites W2140767956 @default.
• W2964742454 cites W2151602943 @default.
• W2964742454 cites W2491689620 @default.
• W2964742454 cites W2526585207 @default.
• W2964742454 cites W2552660163 @default.
• W2964742454 cites W2589922208 @default.
• W2964742454 cites W2603154053 @default.
• W2964742454 cites W2612193115 @default.
• W2964742454 cites W2618191749 @default.
• W2964742454 cites W2624340764 @default.
• W2964742454 cites W2754718069 @default.
• W2964742454 cites W2756779968 @default.
• W2964742454 cites W2772888620 @default.
• W2964742454 cites W2788035303 @default.
• W2964742454 cites W2790065092 @default.
• W2964742454 cites W2794897270 @default.
• W2964742454 doi "https://doi.org/10.1155/2019/8262989" @default.
• W2964742454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6699310" @default.
• W2964742454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31467912" @default.
• W2964742454 hasPublicationYear "2019" @default.
• W2964742454 type Work @default.
• W2964742454 sameAs 2964742454 @default.
• W2964742454 citedByCount "4" @default.
• W2964742454 countsByYear W29647424542022 @default.
• W2964742454 countsByYear W29647424542023 @default.
• W2964742454 crossrefType "journal-article" @default.
• W2964742454 hasAuthorship W2964742454A5001005210 @default.
• W2964742454 hasAuthorship W2964742454A5016118801 @default.
• W2964742454 hasAuthorship W2964742454A5050844331 @default.
• W2964742454 hasAuthorship W2964742454A5072133263 @default.
• W2964742454 hasAuthorship W2964742454A5078964826 @default.
• W2964742454 hasAuthorship W2964742454A5086326013 @default.
• W2964742454 hasAuthorship W2964742454A5090292384 @default.
• W2964742454 hasBestOaLocation W29647424541 @default.
• W2964742454 hasConcept C121608353 @default.
• W2964742454 hasConcept C126322002 @default.
• W2964742454 hasConcept C167672396 @default.
• W2964742454 hasConcept C203014093 @default.
• W2964742454 hasConcept C2780352672 @default.
• W2964742454 hasConcept C2780931953 @default.
• W2964742454 hasConcept C502942594 @default.
• W2964742454 hasConcept C54009773 @default.
• W2964742454 hasConcept C54355233 @default.
• W2964742454 hasConcept C71924100 @default.
• W2964742454 hasConcept C81885089 @default.
• W2964742454 hasConcept C86803240 @default.
• W2964742454 hasConcept C8891405 @default.
• W2964742454 hasConcept C96232424 @default.
• W2964742454 hasConceptScore W2964742454C121608353 @default.
• W2964742454 hasConceptScore W2964742454C126322002 @default.
• W2964742454 hasConceptScore W2964742454C167672396 @default.
• W2964742454 hasConceptScore W2964742454C203014093 @default.
• W2964742454 hasConceptScore W2964742454C2780352672 @default.
• W2964742454 hasConceptScore W2964742454C2780931953 @default.
• W2964742454 hasConceptScore W2964742454C502942594 @default.
• W2964742454 hasConceptScore W2964742454C54009773 @default.
• W2964742454 hasConceptScore W2964742454C54355233 @default.
• W2964742454 hasConceptScore W2964742454C71924100 @default.
• W2964742454 hasConceptScore W2964742454C81885089 @default.
• W2964742454 hasConceptScore W2964742454C86803240 @default.
• W2964742454 hasConceptScore W2964742454C8891405 @default.
• W2964742454 hasConceptScore W2964742454C96232424 @default.
• W2964742454 hasFunder F4320321878 @default.
• W2964742454 hasLocation W29647424541 @default.
• W2964742454 hasLocation W29647424542 @default.
• W2964742454 hasLocation W29647424543 @default.
• W2964742454 hasLocation W29647424544 @default.
• W2964742454 hasOpenAccess W2964742454 @default.
• W2964742454 hasPrimaryLocation W29647424541 @default.
• W2964742454 hasRelatedWork W1963935460 @default.
• W2964742454 hasRelatedWork W2036107469 @default.
• W2964742454 hasRelatedWork W2081358646 @default.
• W2964742454 hasRelatedWork W2465231198 @default.
• W2964742454 hasRelatedWork W2551026632 @default.
• W2964742454 hasRelatedWork W2609459726 @default.
• W2964742454 hasRelatedWork W4283731173 @default.
• W2964742454 hasRelatedWork W4291367166 @default.
• W2964742454 hasRelatedWork W4308359949 @default.

• next