Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964744089> ?p ?o ?g. }
- W2964744089 endingPage "101203" @default.
- W2964744089 startingPage "101203" @default.
- W2964744089 abstract "The main goal of this study was to predict the capacity of the hybrid nanoparticles based on poli (lactic-co-glycolic acid) PLGA-vegetable oil to encapsulate and then to release a bioactive compound. Therefore, the compatibility of different drugs molecules, taking into account the chemical structure, solubility, partition coefficient (log P) with the standard PLGA or hybrid polymer-oil matrix was studied, quantifying the quality of interactions between polymeric matrix and the encapsulated drug using Flory-Huggins theory and computational mesoscopic (MesoDyn) approach. All the drugs-loaded formulations were obtained by emulsion solvent evaporation method. The main parameters such as hydrodynamic characteristics, encapsulation efficiency and release profiles were studied and correlated with the compatibility parameter, drug's partition coefficient and computational mesoscopic simulation. Drugs solubilization, respectively its distribution and loading into a formulation was found to be reliant on the system's compatibility, calculated by the Flory-Huggins interaction parameter (χ), while the drug's partition coefficient has proven to be a key influencer in the drug release kinetics. A consistent correlation of experimental results, computational data and thermodynamic theory was observed for lipophilic drugs, while for more hydrophilic drugs some discrepancy between the experimental/theoretical and computational modelling results was registered." @default.
- W2964744089 created "2019-08-13" @default.
- W2964744089 creator A5040374390 @default.
- W2964744089 creator A5041598483 @default.
- W2964744089 creator A5047154022 @default.
- W2964744089 creator A5056299861 @default.
- W2964744089 creator A5076163205 @default.
- W2964744089 date "2019-10-01" @default.
- W2964744089 modified "2023-10-17" @default.
- W2964744089 title "Predicting the drug loading efficiency into hybrid nanocarriers based on PLGA-vegetable oil using molecular dynamic simulation approach and Flory-Huggins theory" @default.
- W2964744089 cites W1895001004 @default.
- W2964744089 cites W1963956640 @default.
- W2964744089 cites W1964355221 @default.
- W2964744089 cites W1966687729 @default.
- W2964744089 cites W1971429865 @default.
- W2964744089 cites W1979616721 @default.
- W2964744089 cites W1981560107 @default.
- W2964744089 cites W1983819655 @default.
- W2964744089 cites W1985576613 @default.
- W2964744089 cites W1997308573 @default.
- W2964744089 cites W1998343017 @default.
- W2964744089 cites W2003626288 @default.
- W2964744089 cites W2004609041 @default.
- W2964744089 cites W2008365042 @default.
- W2964744089 cites W2012756671 @default.
- W2964744089 cites W2026547531 @default.
- W2964744089 cites W2028490063 @default.
- W2964744089 cites W2028617210 @default.
- W2964744089 cites W2036800762 @default.
- W2964744089 cites W2041015093 @default.
- W2964744089 cites W2043445121 @default.
- W2964744089 cites W2043854890 @default.
- W2964744089 cites W2048556455 @default.
- W2964744089 cites W2070801001 @default.
- W2964744089 cites W2072193564 @default.
- W2964744089 cites W2082599471 @default.
- W2964744089 cites W2091462529 @default.
- W2964744089 cites W2095335502 @default.
- W2964744089 cites W2100562008 @default.
- W2964744089 cites W2104752356 @default.
- W2964744089 cites W2118517626 @default.
- W2964744089 cites W2119068203 @default.
- W2964744089 cites W2122245300 @default.
- W2964744089 cites W2137358252 @default.
- W2964744089 cites W2144748985 @default.
- W2964744089 cites W2150589936 @default.
- W2964744089 cites W2151291833 @default.
- W2964744089 cites W2154853392 @default.
- W2964744089 cites W2170567467 @default.
- W2964744089 cites W2172965081 @default.
- W2964744089 cites W2212686033 @default.
- W2964744089 cites W2302117177 @default.
- W2964744089 cites W2336714112 @default.
- W2964744089 cites W2477754403 @default.
- W2964744089 cites W2593969485 @default.
- W2964744089 cites W2607039646 @default.
- W2964744089 cites W2714449889 @default.
- W2964744089 cites W2767517115 @default.
- W2964744089 cites W2779133494 @default.
- W2964744089 cites W2802528205 @default.
- W2964744089 cites W2804946488 @default.
- W2964744089 cites W2809295976 @default.
- W2964744089 cites W2901839365 @default.
- W2964744089 doi "https://doi.org/10.1016/j.jddst.2019.101203" @default.
- W2964744089 hasPublicationYear "2019" @default.
- W2964744089 type Work @default.
- W2964744089 sameAs 2964744089 @default.
- W2964744089 citedByCount "5" @default.
- W2964744089 countsByYear W29647440892020 @default.
- W2964744089 countsByYear W29647440892021 @default.
- W2964744089 crossrefType "journal-article" @default.
- W2964744089 hasAuthorship W2964744089A5040374390 @default.
- W2964744089 hasAuthorship W2964744089A5041598483 @default.
- W2964744089 hasAuthorship W2964744089A5047154022 @default.
- W2964744089 hasAuthorship W2964744089A5056299861 @default.
- W2964744089 hasAuthorship W2964744089A5076163205 @default.
- W2964744089 hasConcept C100293340 @default.
- W2964744089 hasConcept C121332964 @default.
- W2964744089 hasConcept C127413603 @default.
- W2964744089 hasConcept C155574463 @default.
- W2964744089 hasConcept C155672457 @default.
- W2964744089 hasConcept C159985019 @default.
- W2964744089 hasConcept C171250308 @default.
- W2964744089 hasConcept C177731217 @default.
- W2964744089 hasConcept C178790620 @default.
- W2964744089 hasConcept C18150654 @default.
- W2964744089 hasConcept C185592680 @default.
- W2964744089 hasConcept C192552737 @default.
- W2964744089 hasConcept C192562407 @default.
- W2964744089 hasConcept C2778123984 @default.
- W2964744089 hasConcept C2778648169 @default.
- W2964744089 hasConcept C2779820397 @default.
- W2964744089 hasConcept C2780165375 @default.
- W2964744089 hasConcept C42360764 @default.
- W2964744089 hasConcept C43617362 @default.
- W2964744089 hasConcept C521977710 @default.
- W2964744089 hasConcept C62520636 @default.
- W2964744089 hasConcept C97355855 @default.