Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964746612> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2964746612 endingPage "8559" @default.
- W2964746612 startingPage "8559" @default.
- W2964746612 abstract "8559 Background: Fine motor assessments are important tools to use in screening children undergoing treatment for acute lymphoblastic leukemia (ALL) that may provide decisive data that can reveal subtle changes in neurodevelopment over time. Methods: Fine motor and visual-motor skills were assessed longitudinally in a group of 83 children receiving treatment for ALL. Children in this study had the first fine motor assessment at an average of 8 weeks into treatment and had already received several doses of Vincristine. Fine motor and visual-motor skills assessments were repeated at years 1 and 2 into therapy. The mean age at time of first assessment was 7.2 years and 58% were female. Results: Fine motor speed deficits were evident at the first assessment, and for many, continued to be problematic at Years 1 and 2. In addition to fine motor speed deficits, a significant decline in visual motor integration skills was noted from the baseline level (p = 0.019). Visual motor integration skills observed at Years 1 and 2 were predicted by the baseline performance on the Purdue Pegboard test. Our results indicate that the factors underlying these declines in higher-level skills begin within six months of the onset of chemotherapy. Conclusions: Early reductions in fine motor speed, possibly due to Vincristine, steroids and/or acute Methotrexate toxicity, may lead to reduced visual motor integration and construction abilities. The reduced fine motor skills, which predict eventual declines in visual motor integration, may be part of the underlying process for reduced perceptual abilities and nonverbal intellect often reported in long-term follow-up studies. For children with ALL, motor and sensory-perceptual examinations during treatment may identify those most at risk for significant long-term effects interfering with integration of visual spatial construction. These basic processing skills are necessary elements to the development of higher-level cognitive abilities, including nonverbal intelligence and academic achievement, particularly in arithmetic and written language. Early identification of reduced processing skills can provide an opportunity to identify at risk patients and intervene prior to reduction in these higher-level skills. Supported by NIH/NICHD RO-1 Funding: Grant number HD 37816 No significant financial relationships to disclose." @default.
- W2964746612 created "2019-08-13" @default.
- W2964746612 creator A5012842824 @default.
- W2964746612 creator A5043378144 @default.
- W2964746612 creator A5051061458 @default.
- W2964746612 creator A5059364546 @default.
- W2964746612 creator A5068316683 @default.
- W2964746612 creator A5087384700 @default.
- W2964746612 date "2006-06-20" @default.
- W2964746612 modified "2023-09-26" @default.
- W2964746612 title "Longitudinal evaluation of fine motor deficits in children with leukemia" @default.
- W2964746612 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.8559" @default.
- W2964746612 hasPublicationYear "2006" @default.
- W2964746612 type Work @default.
- W2964746612 sameAs 2964746612 @default.
- W2964746612 citedByCount "1" @default.
- W2964746612 countsByYear W29647466122013 @default.
- W2964746612 crossrefType "journal-article" @default.
- W2964746612 hasAuthorship W2964746612A5012842824 @default.
- W2964746612 hasAuthorship W2964746612A5043378144 @default.
- W2964746612 hasAuthorship W2964746612A5051061458 @default.
- W2964746612 hasAuthorship W2964746612A5059364546 @default.
- W2964746612 hasAuthorship W2964746612A5068316683 @default.
- W2964746612 hasAuthorship W2964746612A5087384700 @default.
- W2964746612 hasConcept C118552586 @default.
- W2964746612 hasConcept C169976356 @default.
- W2964746612 hasConcept C548259974 @default.
- W2964746612 hasConcept C71924100 @default.
- W2964746612 hasConcept C99508421 @default.
- W2964746612 hasConceptScore W2964746612C118552586 @default.
- W2964746612 hasConceptScore W2964746612C169976356 @default.
- W2964746612 hasConceptScore W2964746612C548259974 @default.
- W2964746612 hasConceptScore W2964746612C71924100 @default.
- W2964746612 hasConceptScore W2964746612C99508421 @default.
- W2964746612 hasIssue "18_suppl" @default.
- W2964746612 hasLocation W29647466121 @default.
- W2964746612 hasOpenAccess W2964746612 @default.
- W2964746612 hasPrimaryLocation W29647466121 @default.
- W2964746612 hasRelatedWork W1951818462 @default.
- W2964746612 hasRelatedWork W1983521755 @default.
- W2964746612 hasRelatedWork W1999629361 @default.
- W2964746612 hasRelatedWork W2012385708 @default.
- W2964746612 hasRelatedWork W2040393651 @default.
- W2964746612 hasRelatedWork W2117260088 @default.
- W2964746612 hasRelatedWork W2418764941 @default.
- W2964746612 hasRelatedWork W2966215339 @default.
- W2964746612 hasRelatedWork W3207538634 @default.
- W2964746612 hasRelatedWork W2055139293 @default.
- W2964746612 hasVolume "24" @default.
- W2964746612 isParatext "false" @default.
- W2964746612 isRetracted "false" @default.
- W2964746612 magId "2964746612" @default.
- W2964746612 workType "article" @default.