FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964751275> ?p ?o ?g. }

• W2964751275 endingPage "1828" @default.
• W2964751275 startingPage "1820" @default.
• W2964751275 abstract "Abstract Objective To develop a causal model for the occurrence of neurocysticercosis ( NC )‐related seizures and test hypotheses generated from the model. Methods We used data from a randomized controlled trial comparing albendazole with placebo among patients newly diagnosed with NC . Based on our causal model, we explored the associations among albendazole treatment, NC cyst evolution, and seizure outcomes over 24 months of follow‐up using generalized linear mixed effect models. Results We included 153 participants, of whom 51% received albendazole. The association between seizure outcomes and treatment over time demonstrated lack of linearity and heterogeneity, requiring the inclusion of time‐treatment interaction terms for valid modeling. Participants in the albendazole group had fewer seizures overall and of partial onset at all time points compared with the placebo group, but the difference increased over the first few months following treatment, then decreased over time. Generalized seizures exhibited a more complex association; those in the albendazole group had fewer seizures compared with those in the placebo group for the first few months after treatment, and then the association reversed and those in the placebo arm had fewer seizures. Adjusting for the number of NC cysts in each phase resulted in an attenuation of the strength of association between albendazole and seizure outcomes, consistent with mediation. Among participants in whom all cysts had disappeared (n = 21), none continued to have seizures. Significance Albendazole treatment is associated with a possible reduction in focal seizures in the short term (3‐6 months), perhaps by hastening the resolution of the cysts. However, the effect is not discernible over the long term, because most cysts either calcify or resolve completely, regardless of whether treated with albendazole. The stage of evolution of the cysticercus is an important consideration in the evaluation of albendazole effect on seizure outcome." @default.
• W2964751275 created "2019-08-13" @default.
• W2964751275 creator A5002708685 @default.
• W2964751275 creator A5032673508 @default.
• W2964751275 creator A5034662367 @default.
• W2964751275 creator A5039941340 @default.
• W2964751275 creator A5050529984 @default.
• W2964751275 creator A5074734755 @default.
• W2964751275 creator A5076990289 @default.
• W2964751275 date "2019-07-29" @default.
• W2964751275 modified "2023-10-13" @default.
• W2964751275 title "Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis" @default.
• W2964751275 cites W1492075988 @default.
• W2964751275 cites W1604539019 @default.
• W2964751275 cites W1856724586 @default.
• W2964751275 cites W1967675399 @default.
• W2964751275 cites W1971440513 @default.
• W2964751275 cites W1971572674 @default.
• W2964751275 cites W1978437325 @default.
• W2964751275 cites W2013638467 @default.
• W2964751275 cites W2019329017 @default.
• W2964751275 cites W2019796473 @default.
• W2964751275 cites W2024818273 @default.
• W2964751275 cites W2048525546 @default.
• W2964751275 cites W2049027679 @default.
• W2964751275 cites W2052342278 @default.
• W2964751275 cites W2057835672 @default.
• W2964751275 cites W2058225203 @default.
• W2964751275 cites W2070308214 @default.
• W2964751275 cites W2077654279 @default.
• W2964751275 cites W2078208431 @default.
• W2964751275 cites W2085277686 @default.
• W2964751275 cites W2095311933 @default.
• W2964751275 cites W2099478180 @default.
• W2964751275 cites W2103843936 @default.
• W2964751275 cites W2112028496 @default.
• W2964751275 cites W2125910347 @default.
• W2964751275 cites W2149557450 @default.
• W2964751275 cites W2161047526 @default.
• W2964751275 cites W2275556098 @default.
• W2964751275 cites W2302308194 @default.
• W2964751275 cites W2480680997 @default.
• W2964751275 cites W2490535633 @default.
• W2964751275 cites W2500668598 @default.
• W2964751275 cites W2580190768 @default.
• W2964751275 cites W2594644573 @default.
• W2964751275 cites W2616425192 @default.
• W2964751275 cites W2731488118 @default.
• W2964751275 cites W2752532854 @default.
• W2964751275 cites W2789767660 @default.
• W2964751275 cites W3671714 @default.
• W2964751275 cites W4233266564 @default.
• W2964751275 cites W4236676256 @default.
• W2964751275 cites W4292811746 @default.
• W2964751275 doi "https://doi.org/10.1111/epi.16302" @default.
• W2964751275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6751555" @default.
• W2964751275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31355931" @default.
• W2964751275 hasPublicationYear "2019" @default.
• W2964751275 type Work @default.
• W2964751275 sameAs 2964751275 @default.
• W2964751275 citedByCount "15" @default.
• W2964751275 countsByYear W29647512752020 @default.
• W2964751275 countsByYear W29647512752021 @default.
• W2964751275 countsByYear W29647512752022 @default.
• W2964751275 countsByYear W29647512752023 @default.
• W2964751275 crossrefType "journal-article" @default.
• W2964751275 hasAuthorship W2964751275A5002708685 @default.
• W2964751275 hasAuthorship W2964751275A5032673508 @default.
• W2964751275 hasAuthorship W2964751275A5034662367 @default.
• W2964751275 hasAuthorship W2964751275A5039941340 @default.
• W2964751275 hasAuthorship W2964751275A5050529984 @default.
• W2964751275 hasAuthorship W2964751275A5074734755 @default.
• W2964751275 hasAuthorship W2964751275A5076990289 @default.
• W2964751275 hasBestOaLocation W29647512751 @default.
• W2964751275 hasConcept C118552586 @default.
• W2964751275 hasConcept C141071460 @default.
• W2964751275 hasConcept C142724271 @default.
• W2964751275 hasConcept C15744967 @default.
• W2964751275 hasConcept C187212893 @default.
• W2964751275 hasConcept C204787440 @default.
• W2964751275 hasConcept C27081682 @default.
• W2964751275 hasConcept C2777065887 @default.
• W2964751275 hasConcept C2778186239 @default.
• W2964751275 hasConcept C2780449708 @default.
• W2964751275 hasConcept C42219234 @default.
• W2964751275 hasConcept C71924100 @default.
• W2964751275 hasConceptScore W2964751275C118552586 @default.
• W2964751275 hasConceptScore W2964751275C141071460 @default.
• W2964751275 hasConceptScore W2964751275C142724271 @default.
• W2964751275 hasConceptScore W2964751275C15744967 @default.
• W2964751275 hasConceptScore W2964751275C187212893 @default.
• W2964751275 hasConceptScore W2964751275C204787440 @default.
• W2964751275 hasConceptScore W2964751275C27081682 @default.
• W2964751275 hasConceptScore W2964751275C2777065887 @default.
• W2964751275 hasConceptScore W2964751275C2778186239 @default.
• W2964751275 hasConceptScore W2964751275C2780449708 @default.
• W2964751275 hasConceptScore W2964751275C42219234 @default.
• W2964751275 hasConceptScore W2964751275C71924100 @default.

• next