Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964753452> ?p ?o ?g. }
- W2964753452 endingPage "734" @default.
- W2964753452 startingPage "724" @default.
- W2964753452 abstract "Bariatric surgery represents the most efficacious weight loss treatment for obesity, with targets including reduced gastric capacity and fasting ghrelin and increased postprandial incretin levels. Behavioral and dietetic treatment is the mainstay of long-term management alone or in combination with other treatments. There are essentially no approved pharmacological treatments for obesity in the pediatric age group. Various phenotypes that modify appetite and satiation are identified in obesity. Identifying such phenotypes provides opportunities for individualizing treatment by targeting the putative mechanisms that increase appetite or reduce satiation in pediatric obesity. For the management of obesity in childhood and adolescence, nonoperative approaches have limited efficacy, including community-based and behavioral interventions and pharmacotherapy approved for use in adults. Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy are efficacious in reducing weight, body mass index, and comorbidities in adolescents. Understanding the phenotype associated with obesity provides an opportunity to individualize patients’ treatments directed at the brain–gut axis. These phenotypes include rapid gastric emptying, increased fasting gastric volume, reduced postprandial incretins, and central mechanisms that impact appetite and satiation including hedonic eating and affective disorders. Further studies are required in adolescents. Identifying phenotypes could enhance the efficacy of behavioral, dietary, and pharmacotherapeutic interventions alone or in combination in children and adolescents. For the management of obesity in childhood and adolescence, nonoperative approaches have limited efficacy, including community-based and behavioral interventions and pharmacotherapy approved for use in adults. Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy are efficacious in reducing weight, body mass index, and comorbidities in adolescents. Understanding the phenotype associated with obesity provides an opportunity to individualize patients’ treatments directed at the brain–gut axis. These phenotypes include rapid gastric emptying, increased fasting gastric volume, reduced postprandial incretins, and central mechanisms that impact appetite and satiation including hedonic eating and affective disorders. Further studies are required in adolescents. Identifying phenotypes could enhance the efficacy of behavioral, dietary, and pharmacotherapeutic interventions alone or in combination in children and adolescents." @default.
- W2964753452 created "2019-08-13" @default.
- W2964753452 creator A5017598516 @default.
- W2964753452 creator A5091255858 @default.
- W2964753452 date "2019-10-01" @default.
- W2964753452 modified "2023-09-25" @default.
- W2964753452 title "Insights on Obesity in Children and Adults: Individualizing Management" @default.
- W2964753452 cites W1154188420 @default.
- W2964753452 cites W1580476222 @default.
- W2964753452 cites W1811810449 @default.
- W2964753452 cites W1901819292 @default.
- W2964753452 cites W1949037931 @default.
- W2964753452 cites W1965831360 @default.
- W2964753452 cites W1977624895 @default.
- W2964753452 cites W1980715284 @default.
- W2964753452 cites W1998478414 @default.
- W2964753452 cites W2007370171 @default.
- W2964753452 cites W2008022844 @default.
- W2964753452 cites W2025220785 @default.
- W2964753452 cites W2029438327 @default.
- W2964753452 cites W2037777715 @default.
- W2964753452 cites W2039778454 @default.
- W2964753452 cites W2062336321 @default.
- W2964753452 cites W2066467287 @default.
- W2964753452 cites W2083346852 @default.
- W2964753452 cites W2109995914 @default.
- W2964753452 cites W2115047538 @default.
- W2964753452 cites W2145268530 @default.
- W2964753452 cites W2148623180 @default.
- W2964753452 cites W2149717292 @default.
- W2964753452 cites W2224803273 @default.
- W2964753452 cites W2255282938 @default.
- W2964753452 cites W2260747663 @default.
- W2964753452 cites W2432501512 @default.
- W2964753452 cites W2487833711 @default.
- W2964753452 cites W2509585011 @default.
- W2964753452 cites W2519803668 @default.
- W2964753452 cites W2523260674 @default.
- W2964753452 cites W2542980453 @default.
- W2964753452 cites W2568976536 @default.
- W2964753452 cites W2593996379 @default.
- W2964753452 cites W2601752949 @default.
- W2964753452 cites W2604119137 @default.
- W2964753452 cites W2610007367 @default.
- W2964753452 cites W2620605775 @default.
- W2964753452 cites W2750589465 @default.
- W2964753452 cites W2759588258 @default.
- W2964753452 cites W2762650576 @default.
- W2964753452 cites W2763994560 @default.
- W2964753452 cites W2768727694 @default.
- W2964753452 cites W2782628573 @default.
- W2964753452 cites W2783310372 @default.
- W2964753452 cites W2790476156 @default.
- W2964753452 cites W2790503825 @default.
- W2964753452 cites W2818835171 @default.
- W2964753452 cites W2899483446 @default.
- W2964753452 cites W2900013714 @default.
- W2964753452 cites W2900765417 @default.
- W2964753452 cites W2901670666 @default.
- W2964753452 cites W2914348656 @default.
- W2964753452 cites W2917520831 @default.
- W2964753452 cites W2919223676 @default.
- W2964753452 cites W2936480486 @default.
- W2964753452 cites W2941846524 @default.
- W2964753452 cites W2946221835 @default.
- W2964753452 doi "https://doi.org/10.1016/j.tem.2019.07.016" @default.
- W2964753452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6779521" @default.
- W2964753452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31395427" @default.
- W2964753452 hasPublicationYear "2019" @default.
- W2964753452 type Work @default.
- W2964753452 sameAs 2964753452 @default.
- W2964753452 citedByCount "10" @default.
- W2964753452 countsByYear W29647534522020 @default.
- W2964753452 countsByYear W29647534522021 @default.
- W2964753452 countsByYear W29647534522022 @default.
- W2964753452 crossrefType "journal-article" @default.
- W2964753452 hasAuthorship W2964753452A5017598516 @default.
- W2964753452 hasAuthorship W2964753452A5091255858 @default.
- W2964753452 hasBestOaLocation W29647534522 @default.
- W2964753452 hasConcept C118552586 @default.
- W2964753452 hasConcept C126322002 @default.
- W2964753452 hasConcept C134018914 @default.
- W2964753452 hasConcept C27415008 @default.
- W2964753452 hasConcept C2777180221 @default.
- W2964753452 hasConcept C2778199505 @default.
- W2964753452 hasConcept C2778586554 @default.
- W2964753452 hasConcept C2779306644 @default.
- W2964753452 hasConcept C2779422640 @default.
- W2964753452 hasConcept C2780221984 @default.
- W2964753452 hasConcept C2780586474 @default.
- W2964753452 hasConcept C2781308992 @default.
- W2964753452 hasConcept C3019402062 @default.
- W2964753452 hasConcept C34320749 @default.
- W2964753452 hasConcept C500440147 @default.
- W2964753452 hasConcept C511355011 @default.
- W2964753452 hasConcept C544821477 @default.
- W2964753452 hasConcept C555293320 @default.
- W2964753452 hasConcept C71924100 @default.