Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964753729> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2964753729 abstract "RNA-binding hot spots are dominant and fundamental residues that contribute most to the binding free energy of protein-RNA interfaces. As experimental methods for identifying hot spots are expensive and time-consuming, high-efficiency computational approaches are required in predicting hot spots on a large scale. In this work, we proposed a sequence-based machine learning method to predict hot spots in protein-RNA complexes. We extracted 83 relative independent physicochemical features from a set of the 544 properties in AAindex1. Each physicochemical feature was combined with the predicted relative accessible surface area (RASA) and substitution probability feature from Blocks Substitution Matrix (BLOSUM) for training models by support vector machine (SVM) and k-nearest neighbor algorithm (k-NN). The combinations of the 166 individual models were explored and 33 top-performance models were selected to construct the final ensemble classifier by a majority voting technique. The ensemble classifier outperformed the state-of-the-art computational methods, yielding F1 score of 0.742 and AUC of 0.824 on the independent test set." @default.
- W2964753729 created "2019-08-13" @default.
- W2964753729 creator A5065587600 @default.
- W2964753729 creator A5087986828 @default.
- W2964753729 creator A5089791620 @default.
- W2964753729 date "2019-01-01" @default.
- W2964753729 modified "2023-09-23" @default.
- W2964753729 title "Sequence-Based Prediction of Hot Spots in Protein-RNA Complexes Using an Ensemble Approach" @default.
- W2964753729 cites W1408885899 @default.
- W2964753729 cites W1989181256 @default.
- W2964753729 cites W2005750609 @default.
- W2964753729 cites W2043338013 @default.
- W2964753729 cites W2048917743 @default.
- W2964753729 cites W2058527555 @default.
- W2964753729 cites W2097651980 @default.
- W2964753729 cites W2116498086 @default.
- W2964753729 cites W2119493141 @default.
- W2964753729 cites W2127982146 @default.
- W2964753729 cites W2136206140 @default.
- W2964753729 cites W2143210482 @default.
- W2964753729 cites W2145957695 @default.
- W2964753729 cites W2167884443 @default.
- W2964753729 cites W2739876930 @default.
- W2964753729 cites W2774453250 @default.
- W2964753729 cites W2777941847 @default.
- W2964753729 cites W878378145 @default.
- W2964753729 doi "https://doi.org/10.1007/978-3-030-26763-6_55" @default.
- W2964753729 hasPublicationYear "2019" @default.
- W2964753729 type Work @default.
- W2964753729 sameAs 2964753729 @default.
- W2964753729 citedByCount "0" @default.
- W2964753729 crossrefType "book-chapter" @default.
- W2964753729 hasAuthorship W2964753729A5065587600 @default.
- W2964753729 hasAuthorship W2964753729A5087986828 @default.
- W2964753729 hasAuthorship W2964753729A5089791620 @default.
- W2964753729 hasConcept C113238511 @default.
- W2964753729 hasConcept C11413529 @default.
- W2964753729 hasConcept C119857082 @default.
- W2964753729 hasConcept C119898033 @default.
- W2964753729 hasConcept C12267149 @default.
- W2964753729 hasConcept C124101348 @default.
- W2964753729 hasConcept C153180895 @default.
- W2964753729 hasConcept C153668964 @default.
- W2964753729 hasConcept C154945302 @default.
- W2964753729 hasConcept C41008148 @default.
- W2964753729 hasConcept C45942800 @default.
- W2964753729 hasConcept C95623464 @default.
- W2964753729 hasConceptScore W2964753729C113238511 @default.
- W2964753729 hasConceptScore W2964753729C11413529 @default.
- W2964753729 hasConceptScore W2964753729C119857082 @default.
- W2964753729 hasConceptScore W2964753729C119898033 @default.
- W2964753729 hasConceptScore W2964753729C12267149 @default.
- W2964753729 hasConceptScore W2964753729C124101348 @default.
- W2964753729 hasConceptScore W2964753729C153180895 @default.
- W2964753729 hasConceptScore W2964753729C153668964 @default.
- W2964753729 hasConceptScore W2964753729C154945302 @default.
- W2964753729 hasConceptScore W2964753729C41008148 @default.
- W2964753729 hasConceptScore W2964753729C45942800 @default.
- W2964753729 hasConceptScore W2964753729C95623464 @default.
- W2964753729 hasLocation W29647537291 @default.
- W2964753729 hasOpenAccess W2964753729 @default.
- W2964753729 hasPrimaryLocation W29647537291 @default.
- W2964753729 hasRelatedWork W1519137417 @default.
- W2964753729 hasRelatedWork W1978987398 @default.
- W2964753729 hasRelatedWork W1986913015 @default.
- W2964753729 hasRelatedWork W1992116297 @default.
- W2964753729 hasRelatedWork W2079031047 @default.
- W2964753729 hasRelatedWork W2088592752 @default.
- W2964753729 hasRelatedWork W2151180344 @default.
- W2964753729 hasRelatedWork W2279382006 @default.
- W2964753729 hasRelatedWork W2389180448 @default.
- W2964753729 hasRelatedWork W2389315954 @default.
- W2964753729 hasRelatedWork W2475686134 @default.
- W2964753729 hasRelatedWork W2475855417 @default.
- W2964753729 hasRelatedWork W2791351345 @default.
- W2964753729 hasRelatedWork W2909686100 @default.
- W2964753729 hasRelatedWork W2935793619 @default.
- W2964753729 hasRelatedWork W2965956244 @default.
- W2964753729 hasRelatedWork W3089261895 @default.
- W2964753729 hasRelatedWork W3090413355 @default.
- W2964753729 hasRelatedWork W3090648695 @default.
- W2964753729 hasRelatedWork W2860773754 @default.
- W2964753729 isParatext "false" @default.
- W2964753729 isRetracted "false" @default.
- W2964753729 magId "2964753729" @default.
- W2964753729 workType "book-chapter" @default.