Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964754909> ?p ?o ?g. }
- W2964754909 endingPage "1399.e6" @default.
- W2964754909 startingPage "1389" @default.
- W2964754909 abstract "Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector functions of antibodies. CSR occurs via the formation and non-homologous end joining (NHEJ) repair of programmed DNA double-strand breaks (DSBs) at the immunoglobulin heavy chain locus. The DNA repair factors 53BP1 and Rif1 promote NHEJ and CSR by protecting DSBs against resection. However, to what extent repression of DNA end resection contributes to CSR is unknown. Here, we show that B lymphocytes devoid of 53BP1-Rif1-dependent DSB end protection activity undergo robust CSR. Inactivation of specific sets of phospho-sites within 53BP1 N-terminal SQ/TQ motifs abrogates Rif1 recruitment and inhibition of resection but only mildly reduces CSR. Furthermore, mutations within 53BP1 oligomerization domain abolish CSR without substantially affecting DNA end processing. Thus, inhibition of DNA end resection does not correlate with CSR efficiency, indicating that regulation of DSB processing is not a key determinant step in CSR." @default.
- W2964754909 created "2019-08-13" @default.
- W2964754909 creator A5007091096 @default.
- W2964754909 creator A5008448662 @default.
- W2964754909 creator A5010122056 @default.
- W2964754909 creator A5033892759 @default.
- W2964754909 creator A5037898378 @default.
- W2964754909 creator A5049420037 @default.
- W2964754909 creator A5051357170 @default.
- W2964754909 creator A5059679748 @default.
- W2964754909 creator A5063226643 @default.
- W2964754909 creator A5090860833 @default.
- W2964754909 date "2019-08-01" @default.
- W2964754909 modified "2023-10-12" @default.
- W2964754909 title "53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function" @default.
- W2964754909 cites W1513105954 @default.
- W2964754909 cites W1579358829 @default.
- W2964754909 cites W1766489982 @default.
- W2964754909 cites W1960323088 @default.
- W2964754909 cites W1965428318 @default.
- W2964754909 cites W1967825549 @default.
- W2964754909 cites W1968870521 @default.
- W2964754909 cites W1972564604 @default.
- W2964754909 cites W1973191929 @default.
- W2964754909 cites W1975548607 @default.
- W2964754909 cites W1981525849 @default.
- W2964754909 cites W1987590932 @default.
- W2964754909 cites W1988259427 @default.
- W2964754909 cites W2002043709 @default.
- W2964754909 cites W2007096393 @default.
- W2964754909 cites W2015396326 @default.
- W2964754909 cites W2015414930 @default.
- W2964754909 cites W2028235759 @default.
- W2964754909 cites W2029864255 @default.
- W2964754909 cites W2032117887 @default.
- W2964754909 cites W2036339686 @default.
- W2964754909 cites W2038451572 @default.
- W2964754909 cites W2041809029 @default.
- W2964754909 cites W2045687891 @default.
- W2964754909 cites W2050302428 @default.
- W2964754909 cites W2052981964 @default.
- W2964754909 cites W2053200644 @default.
- W2964754909 cites W2053674184 @default.
- W2964754909 cites W2059574913 @default.
- W2964754909 cites W2067427915 @default.
- W2964754909 cites W2068973408 @default.
- W2964754909 cites W2073622904 @default.
- W2964754909 cites W2077399723 @default.
- W2964754909 cites W2089456325 @default.
- W2964754909 cites W2094164002 @default.
- W2964754909 cites W2096391864 @default.
- W2964754909 cites W2097360161 @default.
- W2964754909 cites W2097521224 @default.
- W2964754909 cites W2097736672 @default.
- W2964754909 cites W2107408311 @default.
- W2964754909 cites W2110015307 @default.
- W2964754909 cites W2114983967 @default.
- W2964754909 cites W2115578008 @default.
- W2964754909 cites W2123215808 @default.
- W2964754909 cites W2126061110 @default.
- W2964754909 cites W2134042008 @default.
- W2964754909 cites W2134230163 @default.
- W2964754909 cites W2141308574 @default.
- W2964754909 cites W2141326900 @default.
- W2964754909 cites W2146204567 @default.
- W2964754909 cites W2146273112 @default.
- W2964754909 cites W2146507524 @default.
- W2964754909 cites W2157899948 @default.
- W2964754909 cites W2159094470 @default.
- W2964754909 cites W2164648414 @default.
- W2964754909 cites W2165608602 @default.
- W2964754909 cites W2167333291 @default.
- W2964754909 cites W2168340438 @default.
- W2964754909 cites W2170380265 @default.
- W2964754909 cites W2224164996 @default.
- W2964754909 cites W2289400000 @default.
- W2964754909 cites W2343411522 @default.
- W2964754909 cites W2437539949 @default.
- W2964754909 cites W2479899483 @default.
- W2964754909 cites W2561038494 @default.
- W2964754909 cites W2567065862 @default.
- W2964754909 cites W2586986076 @default.
- W2964754909 cites W2587772061 @default.
- W2964754909 cites W2593269879 @default.
- W2964754909 cites W2617643755 @default.
- W2964754909 cites W2763962307 @default.
- W2964754909 cites W2783008708 @default.
- W2964754909 cites W2791859276 @default.
- W2964754909 cites W2798183676 @default.
- W2964754909 cites W2807198260 @default.
- W2964754909 cites W2810589479 @default.
- W2964754909 cites W2851014980 @default.
- W2964754909 cites W2883657705 @default.
- W2964754909 cites W2883664363 @default.
- W2964754909 cites W2883789961 @default.
- W2964754909 cites W2884164644 @default.
- W2964754909 cites W2894755169 @default.
- W2964754909 cites W2905535260 @default.