FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964756907> ?p ?o ?g. }

• W2964756907 abstract "ABSTRACT In all animals, the intestinal epithelium forms a tight barrier to the environment. The epithelium regulates the absorption of nutrients, mounts immune responses and prevents systemic infections. Here, we investigate the consequences of tumorigenesis on the microbiome using a Drosophila intestinal tumor model. We show that upon loss-of BMP signaling, tumors lead to aberrant activation of JNK signaling, followed by intestinal barrier dysfunction and commensal imbalance. In turn, the dysbiotic microbiome triggers a regenerative response and stimulates tumor growth. We find that inhibiting JNK signaling or depletion of the microbiome restores barrier function of the intestinal epithelium, leading to a reestablishment of host-microbe homeostasis, and organismic lifespan extension. Our experiments identify a JNK-dependent feedback amplification loop between intestinal tumors and the microbiome. They also highlight the importance of controlling the activity level of JNK signaling to maintain epithelial barrier function and host-microbe homeostasis." @default.
• W2964756907 created "2019-08-13" @default.
• W2964756907 creator A5001159397 @default.
• W2964756907 creator A5066882189 @default.
• W2964756907 date "2019-07-31" @default.
• W2964756907 modified "2023-09-24" @default.
• W2964756907 title "JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis" @default.
• W2964756907 cites W1598771153 @default.
• W2964756907 cites W1822171334 @default.
• W2964756907 cites W1918288286 @default.
• W2964756907 cites W1930889025 @default.
• W2964756907 cites W1934938631 @default.
• W2964756907 cites W1980626846 @default.
• W2964756907 cites W1985234259 @default.
• W2964756907 cites W1989451500 @default.
• W2964756907 cites W1998356880 @default.
• W2964756907 cites W2004562554 @default.
• W2964756907 cites W2005334224 @default.
• W2964756907 cites W2006373538 @default.
• W2964756907 cites W2010125549 @default.
• W2964756907 cites W2012178564 @default.
• W2964756907 cites W2013669259 @default.
• W2964756907 cites W2018440302 @default.
• W2964756907 cites W2019703934 @default.
• W2964756907 cites W2030896914 @default.
• W2964756907 cites W2034082915 @default.
• W2964756907 cites W2040657364 @default.
• W2964756907 cites W2068234766 @default.
• W2964756907 cites W2071872378 @default.
• W2964756907 cites W2076912393 @default.
• W2964756907 cites W2085322703 @default.
• W2964756907 cites W2089246633 @default.
• W2964756907 cites W2095132285 @default.
• W2964756907 cites W2099792666 @default.
• W2964756907 cites W2105575647 @default.
• W2964756907 cites W2110367574 @default.
• W2964756907 cites W2110628864 @default.
• W2964756907 cites W2127937061 @default.
• W2964756907 cites W2135279653 @default.
• W2964756907 cites W2142018200 @default.
• W2964756907 cites W2142360030 @default.
• W2964756907 cites W2144592907 @default.
• W2964756907 cites W2151219707 @default.
• W2964756907 cites W2153718995 @default.
• W2964756907 cites W2154073936 @default.
• W2964756907 cites W2164874402 @default.
• W2964756907 cites W2165885715 @default.
• W2964756907 cites W2167163043 @default.
• W2964756907 cites W2256633912 @default.
• W2964756907 cites W2264871965 @default.
• W2964756907 cites W2268396895 @default.
• W2964756907 cites W2273290385 @default.
• W2964756907 cites W2341544718 @default.
• W2964756907 cites W2395064609 @default.
• W2964756907 cites W2515623196 @default.
• W2964756907 cites W2551899789 @default.
• W2964756907 cites W2568451172 @default.
• W2964756907 cites W2591594701 @default.
• W2964756907 cites W2597344925 @default.
• W2964756907 cites W2770269406 @default.
• W2964756907 cites W2786835440 @default.
• W2964756907 cites W2790031010 @default.
• W2964756907 cites W2790323571 @default.
• W2964756907 cites W2795250330 @default.
• W2964756907 cites W2798050410 @default.
• W2964756907 cites W2808902345 @default.
• W2964756907 cites W2810801201 @default.
• W2964756907 cites W2895124934 @default.
• W2964756907 cites W2898243280 @default.
• W2964756907 cites W2900814239 @default.
• W2964756907 cites W2909426350 @default.
• W2964756907 doi "https://doi.org/10.1101/719468" @default.
• W2964756907 hasPublicationYear "2019" @default.
• W2964756907 type Work @default.
• W2964756907 sameAs 2964756907 @default.
• W2964756907 citedByCount "0" @default.
• W2964756907 crossrefType "posted-content" @default.
• W2964756907 hasAuthorship W2964756907A5001159397 @default.
• W2964756907 hasAuthorship W2964756907A5066882189 @default.
• W2964756907 hasBestOaLocation W29647569071 @default.
• W2964756907 hasConcept C121608353 @default.
• W2964756907 hasConcept C14036430 @default.
• W2964756907 hasConcept C143121216 @default.
• W2964756907 hasConcept C203014093 @default.
• W2964756907 hasConcept C2781077229 @default.
• W2964756907 hasConcept C51911345 @default.
• W2964756907 hasConcept C529295009 @default.
• W2964756907 hasConcept C54355233 @default.
• W2964756907 hasConcept C555283112 @default.
• W2964756907 hasConcept C60644358 @default.
• W2964756907 hasConcept C62478195 @default.
• W2964756907 hasConcept C63645605 @default.
• W2964756907 hasConcept C86803240 @default.
• W2964756907 hasConcept C8891405 @default.
• W2964756907 hasConcept C95444343 @default.
• W2964756907 hasConceptScore W2964756907C121608353 @default.
• W2964756907 hasConceptScore W2964756907C14036430 @default.
• W2964756907 hasConceptScore W2964756907C143121216 @default.
• W2964756907 hasConceptScore W2964756907C203014093 @default.
• W2964756907 hasConceptScore W2964756907C2781077229 @default.

• next