Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964759996> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W2964759996 abstract "9546 Background: Despite a median age at diagnosis of 72, elderly pancreatic cancer patients (pts) are poorly represented in clinical trials. We thus compared patterns of care and outcomes of mPC pts ≤ and > 65 yrs of age. Methods: We retrospectively analyzed medical charts of 277 mPC pts treated at an academic center between 2000 and 2009. Age groups ≤ 65 yrs and >65 yrs were compared with respect to gender, comorbidities, performance status (PS), tobacco/alcohol use, primary site, stage, histological grade, metastatic sites, treatment modalities, type and number of chemotherapeutic agents received, and survival after diagnosis of mPC (OS). Log-rank tests and Cox proportional hazards models were used to analyze survival endpoints and Fisher’s exact test to compare categorical variables. Results: 155 pts ≤65 yrs with median age of 58 and 122 pts >65 yrs with median age of 73.5 were evaluated. The groups were well balanced with respect to sex (majority male), PS (majority ≤1), stage (majority 3, 4), and primary site (majority head). Cardiovascular (CV) disease was more prevalent among older pts (OR 1.7, p=0.04). Older pts were less likely to receive any chemotherapy for mPC (79% vs 92%; OR 0.33, p< 0.001) and if treated were less likely to receive more than one agent (34% vs 52%; OR 0.48, p=0.003). Median OS was shorter in older pts (5m vs 6m, p=0.01). OS was longer with higher number of agents received (RR: 0.57 for young, 0.51 for old; p< 0.001). CV and renal disease negatively impacted OS only in younger pts. The presence of lung metastases was associated with longer survival (10m vs 6m (p=0.01)) and liver metastases with decreased survival (5m vs 8m (p<0.01)) only among younger pts. Conclusions: Elderly mPC pts have shorter OS, are less likely to receive chemotherapy, and if treated receive fewer agents compared to younger pts. These differences cannot be explained solely by PS or disease characteristics and warrant further study." @default.
- W2964759996 created "2019-08-13" @default.
- W2964759996 creator A5002058350 @default.
- W2964759996 creator A5031081545 @default.
- W2964759996 creator A5045353148 @default.
- W2964759996 creator A5065431287 @default.
- W2964759996 creator A5068725191 @default.
- W2964759996 creator A5072144086 @default.
- W2964759996 date "2013-05-20" @default.
- W2964759996 modified "2023-09-28" @default.
- W2964759996 title "Differences in patterns of care and outcomes of elderly versus younger metastatic pancreatic cancer (mPC) patients." @default.
- W2964759996 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.9546" @default.
- W2964759996 hasPublicationYear "2013" @default.
- W2964759996 type Work @default.
- W2964759996 sameAs 2964759996 @default.
- W2964759996 citedByCount "2" @default.
- W2964759996 countsByYear W29647599962013 @default.
- W2964759996 countsByYear W29647599962016 @default.
- W2964759996 crossrefType "journal-article" @default.
- W2964759996 hasAuthorship W2964759996A5002058350 @default.
- W2964759996 hasAuthorship W2964759996A5031081545 @default.
- W2964759996 hasAuthorship W2964759996A5045353148 @default.
- W2964759996 hasAuthorship W2964759996A5065431287 @default.
- W2964759996 hasAuthorship W2964759996A5068725191 @default.
- W2964759996 hasAuthorship W2964759996A5072144086 @default.
- W2964759996 hasConcept C121608353 @default.
- W2964759996 hasConcept C126322002 @default.
- W2964759996 hasConcept C143998085 @default.
- W2964759996 hasConcept C2780210213 @default.
- W2964759996 hasConcept C535046627 @default.
- W2964759996 hasConcept C71924100 @default.
- W2964759996 hasConceptScore W2964759996C121608353 @default.
- W2964759996 hasConceptScore W2964759996C126322002 @default.
- W2964759996 hasConceptScore W2964759996C143998085 @default.
- W2964759996 hasConceptScore W2964759996C2780210213 @default.
- W2964759996 hasConceptScore W2964759996C535046627 @default.
- W2964759996 hasConceptScore W2964759996C71924100 @default.
- W2964759996 hasLocation W29647599961 @default.
- W2964759996 hasOpenAccess W2964759996 @default.
- W2964759996 hasPrimaryLocation W29647599961 @default.
- W2964759996 isParatext "false" @default.
- W2964759996 isRetracted "false" @default.
- W2964759996 magId "2964759996" @default.
- W2964759996 workType "article" @default.