Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964768900> ?p ?o ?g. }
- W2964768900 abstract "Diffuse Large B-Cell Lymphoma (DLBCL) is a clinically and biologically heterogeneous disease. The revised Classification of Lymphoproliferative diseases published in 2016 (WHO, 2016) refined the previous DLBLC subtypes and identified four categories: DLBCL not otherwise specified (NOS), other lymphomas of large B cells, high grade B-cell lymphoma, and B-cell lymphoma unclassifiable. High grade B-cell lymphomas include the entities carrying MYC, BCL2 and/or BCL6 translocations or cases with blastoid morphology without DH translocations. This classification also acknowledges the cell of origin (COO) classification, that has only a limited impact on the choice of frontline treatment for DLBCL, as most patients still receive R-CHOP chemoimmunotherapy. Attempts to improve the outcomes of specific subgroups, especially COO groups, have so far had limited success. Newer analyses have further subdivided DLBCL into genomically distinct subsets, not yet incorporated in the WHO classification, which may facilitate targeted approaches to therapy. In this review, we discuss the subgroups that are recognized by the WHO 2016 classification, review the newer genomic data, and speculate on how this could alter the treatment landscape of DLBCL in the future. We also discuss novel approaches to salvage therapy in the broad context of the heterogeneity of DLBCL." @default.
- W2964768900 created "2019-08-13" @default.
- W2964768900 creator A5000403848 @default.
- W2964768900 creator A5011648025 @default.
- W2964768900 creator A5053560614 @default.
- W2964768900 creator A5054623894 @default.
- W2964768900 creator A5064544139 @default.
- W2964768900 creator A5088077600 @default.
- W2964768900 date "2019-07-30" @default.
- W2964768900 modified "2023-10-16" @default.
- W2964768900 title "Are We Ready to Treat Diffuse Large B-cell and High-Grade Lymphoma According to Major Genetic Subtypes?" @default.
- W2964768900 cites W1020989877 @default.
- W2964768900 cites W1662417834 @default.
- W2964768900 cites W1966542058 @default.
- W2964768900 cites W1976564639 @default.
- W2964768900 cites W1979816280 @default.
- W2964768900 cites W1980068016 @default.
- W2964768900 cites W1982834279 @default.
- W2964768900 cites W1988703453 @default.
- W2964768900 cites W1995939575 @default.
- W2964768900 cites W2006070956 @default.
- W2964768900 cites W2007050465 @default.
- W2964768900 cites W2018071905 @default.
- W2964768900 cites W2023428359 @default.
- W2964768900 cites W2026374501 @default.
- W2964768900 cites W2028850684 @default.
- W2964768900 cites W2037796411 @default.
- W2964768900 cites W2043622833 @default.
- W2964768900 cites W2056555760 @default.
- W2964768900 cites W2056641238 @default.
- W2964768900 cites W2058015212 @default.
- W2964768900 cites W2068343048 @default.
- W2964768900 cites W2077848703 @default.
- W2964768900 cites W2096764404 @default.
- W2964768900 cites W2100090512 @default.
- W2964768900 cites W2111530307 @default.
- W2964768900 cites W2111716055 @default.
- W2964768900 cites W2111827890 @default.
- W2964768900 cites W2113764179 @default.
- W2964768900 cites W2116382435 @default.
- W2964768900 cites W2117460825 @default.
- W2964768900 cites W2120415962 @default.
- W2964768900 cites W2120601121 @default.
- W2964768900 cites W2125523937 @default.
- W2964768900 cites W2126772526 @default.
- W2964768900 cites W2126779872 @default.
- W2964768900 cites W2133345449 @default.
- W2964768900 cites W2135860817 @default.
- W2964768900 cites W2136060045 @default.
- W2964768900 cites W2136268782 @default.
- W2964768900 cites W2139836848 @default.
- W2964768900 cites W2145453495 @default.
- W2964768900 cites W2147246240 @default.
- W2964768900 cites W2150129319 @default.
- W2964768900 cites W2150587745 @default.
- W2964768900 cites W2153558008 @default.
- W2964768900 cites W2153944703 @default.
- W2964768900 cites W2155495849 @default.
- W2964768900 cites W2158267770 @default.
- W2964768900 cites W2160305510 @default.
- W2964768900 cites W2166900358 @default.
- W2964768900 cites W2171356556 @default.
- W2964768900 cites W2190557097 @default.
- W2964768900 cites W2192121806 @default.
- W2964768900 cites W2209610921 @default.
- W2964768900 cites W2236959863 @default.
- W2964768900 cites W2279127916 @default.
- W2964768900 cites W2310716991 @default.
- W2964768900 cites W2528108577 @default.
- W2964768900 cites W2582696216 @default.
- W2964768900 cites W2598700764 @default.
- W2964768900 cites W2610797169 @default.
- W2964768900 cites W2614435853 @default.
- W2964768900 cites W2622965233 @default.
- W2964768900 cites W2724409437 @default.
- W2964768900 cites W2742627598 @default.
- W2964768900 cites W2744261860 @default.
- W2964768900 cites W2751075585 @default.
- W2964768900 cites W2768810256 @default.
- W2964768900 cites W2791299132 @default.
- W2964768900 cites W2797584152 @default.
- W2964768900 cites W2801763724 @default.
- W2964768900 cites W2810840907 @default.
- W2964768900 cites W2892326722 @default.
- W2964768900 cites W2896783905 @default.
- W2964768900 cites W2900423903 @default.
- W2964768900 cites W2900733038 @default.
- W2964768900 cites W2900884053 @default.
- W2964768900 cites W2902000787 @default.
- W2964768900 cites W2902608107 @default.
- W2964768900 cites W2903062212 @default.
- W2964768900 cites W2903225254 @default.
- W2964768900 cites W2903669497 @default.
- W2964768900 cites W2906604246 @default.
- W2964768900 cites W2909854490 @default.
- W2964768900 cites W2922237910 @default.
- W2964768900 cites W2923453543 @default.
- W2964768900 cites W2927138762 @default.
- W2964768900 cites W2945217152 @default.
- W2964768900 cites W2951720456 @default.