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• W2964779058 abstract "Abstract Antigen 43 (Ag43) is a cell-surface exposed protein of Escherichia coli secreted by the Type V, subtype a, secretion system (T5aSS) and belonging to the family of self-associating autotransporters (SAATs). These modular proteins, comprising a cleavable N-terminal signal peptide, a surface-exposed central passenger and an outer membrane C-terminal translocator, self-recognise in a Velcro-like handshake mechanism. A phylogenetic network analysis focusing on the passenger revealed for the first time that they actually distribute into four distinct classes, namely C1, C2, C3 and C4. Structural alignment and modelling analyses demonstrated these classes arose from shuffling of two different subdomains within the Ag43 passengers. Functional analyses revealed that homotypic interactions occur for all Ag43 classes but significant differences in the sedimentation kinetics and aggregation state were present when Ag43 C3 was expressed. In contrast, heterotypic interaction occurred in a very limited number of cases. Single cell-force spectroscopy demonstrated the importance of specific as well as nonspecific interactions in mediating Ag43-Ag43 recognition. We propose that structural differences in the subdomains of the Ag43 classes account for different autoaggregation dynamics and propensities to co-interact." @default.
• W2964779058 created "2019-08-13" @default.
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• W2964779058 date "2019-07-31" @default.
• W2964779058 modified "2023-10-14" @default.
• W2964779058 title "Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation" @default.
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• W2964779058 doi "https://doi.org/10.1038/s41598-019-47608-4" @default.
• W2964779058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6668479" @default.
• W2964779058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31367003" @default.
• W2964779058 hasPublicationYear "2019" @default.
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