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- W2964779492 abstract "Despite recent extensive genomic and genetic studies on behavioral responses to ethanol, relatively few new therapeutic targets for the treatment of alcohol use disorder have been validated. Here we describe a cross-species genomic approach focused on identifying gene networks associated with chronic ethanol consumption. To identify brain mechanisms underlying a chronic ethanol consumption phenotype highly relevant to human alcohol use disorder, and to elucidate potential future therapeutic targets, we conducted a genomic study in a nonhuman primate model of chronic open-access ethanol consumption. Microarray analysis of RNA expression in anterior cingulate and subgenual cortices from rhesus macaques was performed across multiple cohorts of animals. Gene networks correlating with ethanol consumption or showing enrichment for ethanol-regulated genes were identified, as were major ethanol-related hub genes within these networks. A subsequent consensus module analysis was used to co-analyze monkey data with expression data from a chronic intermittent ethanol vapor-exposure and consumption model in C57BL/6J mice. Ethanol-related gene networks conserved between primates and rodents were enriched for genes involved discrete biological functions, including; myelination, synaptic transmission, chromatin modification, Golgi apparatus function, translation, cellular respiration, and RNA processing. The myelin-related network, in particular, showed strong correlations with ethanol consumption behavior and displayed marked network reorganization between control and ethanol-drinking animals. Further bioinformatics analysis revealed that these networks also showed highly significant overlap with other ethanol-regulated gene sets. Altogether, these studies provide robust primate and rodent cross-species validation of gene networks associated with chronic ethanol consumption. Our results also suggest potential novel focal points for future therapeutic interventions in alcohol use disorder." @default.
- W2964779492 created "2019-08-13" @default.
- W2964779492 creator A5023439185 @default.
- W2964779492 creator A5043967154 @default.
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- W2964779492 creator A5091313155 @default.
- W2964779492 date "2019-08-13" @default.
- W2964779492 modified "2023-10-14" @default.
- W2964779492 title "Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys" @default.
- W2964779492 cites W1492036140 @default.
- W2964779492 cites W1513681147 @default.
- W2964779492 cites W1534280022 @default.
- W2964779492 cites W1582811168 @default.
- W2964779492 cites W1627886265 @default.
- W2964779492 cites W1864400744 @default.
- W2964779492 cites W1956824672 @default.
- W2964779492 cites W1963556215 @default.
- W2964779492 cites W1964305071 @default.
- W2964779492 cites W1966327575 @default.
- W2964779492 cites W1966957642 @default.
- W2964779492 cites W1967390196 @default.
- W2964779492 cites W1969412061 @default.
- W2964779492 cites W1977701854 @default.
- W2964779492 cites W1979782774 @default.
- W2964779492 cites W1987256529 @default.
- W2964779492 cites W1989615119 @default.
- W2964779492 cites W1991678197 @default.
- W2964779492 cites W1993570554 @default.
- W2964779492 cites W2003797434 @default.
- W2964779492 cites W2009833394 @default.
- W2964779492 cites W2012016429 @default.
- W2964779492 cites W2012367918 @default.
- W2964779492 cites W2015095602 @default.
- W2964779492 cites W2016149358 @default.
- W2964779492 cites W2016319122 @default.
- W2964779492 cites W2018639131 @default.
- W2964779492 cites W2021261685 @default.
- W2964779492 cites W2035389927 @default.
- W2964779492 cites W2042070051 @default.
- W2964779492 cites W2042909116 @default.
- W2964779492 cites W2045348002 @default.
- W2964779492 cites W2050712231 @default.
- W2964779492 cites W2055380934 @default.
- W2964779492 cites W2065662378 @default.
- W2964779492 cites W2066581849 @default.
- W2964779492 cites W2069929382 @default.
- W2964779492 cites W2070601362 @default.
- W2964779492 cites W2071878436 @default.
- W2964779492 cites W2075038536 @default.
- W2964779492 cites W2080133581 @default.
- W2964779492 cites W2081098333 @default.
- W2964779492 cites W2081837126 @default.
- W2964779492 cites W2082964100 @default.
- W2964779492 cites W2091901410 @default.
- W2964779492 cites W2092677426 @default.
- W2964779492 cites W2093438567 @default.
- W2964779492 cites W2096379390 @default.
- W2964779492 cites W2105809102 @default.
- W2964779492 cites W2105952206 @default.
- W2964779492 cites W2107665951 @default.
- W2964779492 cites W2112044690 @default.
- W2964779492 cites W2113480508 @default.
- W2964779492 cites W2116634113 @default.
- W2964779492 cites W2121965670 @default.
- W2964779492 cites W2125823313 @default.
- W2964779492 cites W2131731860 @default.
- W2964779492 cites W2134239458 @default.
- W2964779492 cites W2135592475 @default.
- W2964779492 cites W2136550122 @default.
- W2964779492 cites W2139511828 @default.
- W2964779492 cites W2145125795 @default.
- W2964779492 cites W2147963611 @default.
- W2964779492 cites W2149755517 @default.
- W2964779492 cites W2153408289 @default.
- W2964779492 cites W2153773787 @default.
- W2964779492 cites W2154240202 @default.
- W2964779492 cites W2157152722 @default.
- W2964779492 cites W2158682367 @default.
- W2964779492 cites W2158818463 @default.
- W2964779492 cites W2163695767 @default.
- W2964779492 cites W2164242630 @default.
- W2964779492 cites W2164944170 @default.
- W2964779492 cites W2226740446 @default.
- W2964779492 cites W2229368468 @default.
- W2964779492 cites W2229952668 @default.
- W2964779492 cites W2274185334 @default.
- W2964779492 cites W2361641503 @default.
- W2964779492 cites W2410502291 @default.
- W2964779492 cites W2479791564 @default.
- W2964779492 cites W2517333721 @default.
- W2964779492 cites W2546965490 @default.
- W2964779492 cites W2549789192 @default.
- W2964779492 cites W2592288917 @default.
- W2964779492 cites W2757690048 @default.
- W2964779492 cites W2767105672 @default.
- W2964779492 cites W2802261945 @default.