Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964802508> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2964802508 endingPage "70" @default.
- W2964802508 startingPage "60" @default.
- W2964802508 abstract "Methods for the synthesis of methyl, ethyl and butyl esters of meta- and para-pentafluoroethoxybenzoic acids starting with respective hydroxybenzoic acids have been developed. Firstly m- and p-hydroxybenzoic acids were esterificated with respective alcohol, and then obtained esters were treated with trifluoroacetic anhydride giving m- or p-alkyl trifluoroacetoxybenzoates that were treated with SF4 in anhydrous HF medium. Conditions for obtaining esters of meta- and para-pentafluoroethoxybenzoic acids with good yields have been discovered. It has been shown that the yields and ratios of the reaction products depend little on the size of the alkyl radical of the alkoxycarbonyl group, but substantially depend on the temperature, duration of the reaction, and the intensity of mixing. The lack of mixing of the reaction medium during treatment of m- and p-trifluoroacetoxybenzoates with SF4-HF leads to the cleavage of the trifluoroacetoxy group with the formation of the corresponding esters of m- and p-hydroxybenzoic acids. Increasing reaction temperature leads to formation of m- and p-pentafluoroethoxybenzotrifluorides in higher yields. Increasing duration of the reaction affects the same way. Anesthetic activity of obtained esters of meta- and para-pentafluoroethoxybenzoic acids was tested using white outbreed male mice. The esters have higher anesthetic activity compared to anesthesine. Ethyl para-pentafluoroethoxybenzoate exhibits the best anesthetic properties among the compounds obtained. meta-Pentafluoroethoxybenzoic acid has been obtained by means of hydrolysis of ethyl meta-pentafluoroethoxybenzoate. The acid has been treated with equimolar quantity of NaOH solution giving respective salt. The last one was then treated with 2-chloro-N,Ndiethylethanamine in DMF solution, giving analogue of novocaine with pentafluoroethoxy group in the meta-position of the benzene ring. Thus obtained novocaine analogue has also higher anesthetic activity compared to anesthesine." @default.
- W2964802508 created "2019-08-13" @default.
- W2964802508 creator A5051674152 @default.
- W2964802508 creator A5076807937 @default.
- W2964802508 creator A5080271079 @default.
- W2964802508 date "2019-05-31" @default.
- W2964802508 modified "2023-09-26" @default.
- W2964802508 title "SYNTHESIS OF FLUORINE-CONTAINING ANALOGS OF ANESTHESINE AND NOVOKAINE" @default.
- W2964802508 doi "https://doi.org/10.18524/2304-0947.2019.2(70).169230" @default.
- W2964802508 hasPublicationYear "2019" @default.
- W2964802508 type Work @default.
- W2964802508 sameAs 2964802508 @default.
- W2964802508 citedByCount "0" @default.
- W2964802508 crossrefType "journal-article" @default.
- W2964802508 hasAuthorship W2964802508A5051674152 @default.
- W2964802508 hasAuthorship W2964802508A5076807937 @default.
- W2964802508 hasAuthorship W2964802508A5080271079 @default.
- W2964802508 hasBestOaLocation W29648025081 @default.
- W2964802508 hasConcept C155647269 @default.
- W2964802508 hasConcept C178790620 @default.
- W2964802508 hasConcept C185592680 @default.
- W2964802508 hasConcept C187714232 @default.
- W2964802508 hasConcept C2780112151 @default.
- W2964802508 hasConcept C2780263894 @default.
- W2964802508 hasConcept C2781066024 @default.
- W2964802508 hasConcept C2781143453 @default.
- W2964802508 hasConcept C2994242795 @default.
- W2964802508 hasConcept C94412978 @default.
- W2964802508 hasConceptScore W2964802508C155647269 @default.
- W2964802508 hasConceptScore W2964802508C178790620 @default.
- W2964802508 hasConceptScore W2964802508C185592680 @default.
- W2964802508 hasConceptScore W2964802508C187714232 @default.
- W2964802508 hasConceptScore W2964802508C2780112151 @default.
- W2964802508 hasConceptScore W2964802508C2780263894 @default.
- W2964802508 hasConceptScore W2964802508C2781066024 @default.
- W2964802508 hasConceptScore W2964802508C2781143453 @default.
- W2964802508 hasConceptScore W2964802508C2994242795 @default.
- W2964802508 hasConceptScore W2964802508C94412978 @default.
- W2964802508 hasIssue "2(70)" @default.
- W2964802508 hasLocation W29648025081 @default.
- W2964802508 hasOpenAccess W2964802508 @default.
- W2964802508 hasPrimaryLocation W29648025081 @default.
- W2964802508 hasRelatedWork W1969378509 @default.
- W2964802508 hasRelatedWork W1986026287 @default.
- W2964802508 hasRelatedWork W1988578872 @default.
- W2964802508 hasRelatedWork W2025424234 @default.
- W2964802508 hasRelatedWork W2048006134 @default.
- W2964802508 hasRelatedWork W2078467384 @default.
- W2964802508 hasRelatedWork W2141671683 @default.
- W2964802508 hasRelatedWork W2345765084 @default.
- W2964802508 hasRelatedWork W2951357193 @default.
- W2964802508 hasRelatedWork W4252193393 @default.
- W2964802508 hasVolume "25" @default.
- W2964802508 isParatext "false" @default.
- W2964802508 isRetracted "false" @default.
- W2964802508 magId "2964802508" @default.
- W2964802508 workType "article" @default.