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• W2964806508 abstract "In this paper, we are investigating the interaction between different passive material models and the mechano-electrical feedback (MEF) in cardiac modelling. Various types of passive mechanical laws (nearly incompressible/compressible, polynomial/exponential-type, transversally isotropic/orthotropic material models) are integrated in a fully coupled electromechanical model in order to study their specific influence on the overall MEF behaviour. Our computational model is based on a three-dimensional (3D) geometry of a healthy rat left ventricle reconstructed from magnetic resonance imaging (MRI). The electromechanically coupled problem is solved using a fully implicit finite element-based approach. The effects of different passive material models on the MEF are studied with the help of numerical examples. It turns out that there is a significant difference between the behaviour of the MEF for compressible and incompressible material models. Numerical results for the incompressible models exhibit that a change in the electrophysiology can be observed such that the transmembrane potential (TP) is unable to reach the resting state in the repolarisation phase and this leads to non-zero relaxation deformations. The most significant and strongest effects of the MEF on the rat cardiac muscle response are observed for the exponential passive material law." @default.
• W2964806508 created "2019-08-13" @default.
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• W2964806508 date "2019-09-24" @default.
• W2964806508 modified "2023-10-10" @default.
• W2964806508 title "Interaction of the Mechano-Electrical Feedback With Passive Mechanical Models on a 3D Rat Left Ventricle: A Computational Study" @default.
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• W2964806508 doi "https://doi.org/10.3389/fphys.2019.01041" @default.
• W2964806508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6769123" @default.
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• W2964806508 hasPublicationYear "2019" @default.
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