FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964838043> ?p ?o ?g. }

• W2964838043 abstract "Hepatitis B is a major public health problem in China. Accurate liver injury assessment is essential for clinical evidence-based treatment. Liver biopsy is considered the gold standard method to stage liver disease, but it is not widely used in resource-limited settings. Therefore, non-invasive liquid biopsy tests are needed.To assess liver injury in hepatitis B patients using quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method.A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. Ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay.Compared with healthy controls, patients with hepatitis B virus (HBV) infection had significantly higher plasma DNA, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and HBV DNA levels (P < 0.01). Serum ALT, AST, bilirubin, and plasma DNA levels of patients with marked-severe inflammation were significantly higher than those with mild-moderate inflammation (P < 0.01). There was a statistically significant correlation between hepatocyte inflammation severity and serum bilirubin (R2 = 0.673, P < 0.01) or plasma DNA (R2 = 0.597, P < 0.01) levels. The areas under the curves of serum ALT, bilirubin, plasma DNA, and their combination to distinguish between patients with mild-moderate and marked-severe inflammation were 0.8059, 0.7910, 0.7921, and 0.9564, respectively.The combination of plasma DNA, serum ALT, and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients." @default.
• W2964838043 created "2019-08-13" @default.
• W2964838043 creator A5001661010 @default.
• W2964838043 creator A5001769823 @default.
• W2964838043 creator A5002312405 @default.
• W2964838043 creator A5007047764 @default.
• W2964838043 creator A5029885579 @default.
• W2964838043 creator A5039441880 @default.
• W2964838043 creator A5047395203 @default.
• W2964838043 creator A5077173527 @default.
• W2964838043 creator A5078465675 @default.
• W2964838043 creator A5086759035 @default.
• W2964838043 date "2019-08-07" @default.
• W2964838043 modified "2023-09-23" @default.
• W2964838043 title "Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients" @default.
• W2964838043 cites W1799522345 @default.
• W2964838043 cites W1899463239 @default.
• W2964838043 cites W1966733471 @default.
• W2964838043 cites W1973109750 @default.
• W2964838043 cites W1973375897 @default.
• W2964838043 cites W1981900811 @default.
• W2964838043 cites W1984063837 @default.
• W2964838043 cites W2002163127 @default.
• W2964838043 cites W2010059853 @default.
• W2964838043 cites W2023230646 @default.
• W2964838043 cites W2024692616 @default.
• W2964838043 cites W2044951291 @default.
• W2964838043 cites W2048976883 @default.
• W2964838043 cites W2068670805 @default.
• W2964838043 cites W2069410357 @default.
• W2964838043 cites W2084857559 @default.
• W2964838043 cites W2092479048 @default.
• W2964838043 cites W2120649999 @default.
• W2964838043 cites W2126239952 @default.
• W2964838043 cites W2135672265 @default.
• W2964838043 cites W2136776221 @default.
• W2964838043 cites W2145050940 @default.
• W2964838043 cites W2159954692 @default.
• W2964838043 cites W2186721704 @default.
• W2964838043 cites W2194166243 @default.
• W2964838043 cites W2435305424 @default.
• W2964838043 cites W2462566639 @default.
• W2964838043 cites W2465783087 @default.
• W2964838043 cites W2512452943 @default.
• W2964838043 cites W2551443857 @default.
• W2964838043 cites W2561544420 @default.
• W2964838043 cites W2569584951 @default.
• W2964838043 cites W2608919594 @default.
• W2964838043 cites W3030413268 @default.
• W2964838043 doi "https://doi.org/10.3748/wjg.v25.i29.3985" @default.
• W2964838043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6689808" @default.
• W2964838043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31413532" @default.
• W2964838043 hasPublicationYear "2019" @default.
• W2964838043 type Work @default.
• W2964838043 sameAs 2964838043 @default.
• W2964838043 citedByCount "6" @default.
• W2964838043 countsByYear W29648380432020 @default.
• W2964838043 countsByYear W29648380432021 @default.
• W2964838043 crossrefType "journal-article" @default.
• W2964838043 hasAuthorship W2964838043A5001661010 @default.
• W2964838043 hasAuthorship W2964838043A5001769823 @default.
• W2964838043 hasAuthorship W2964838043A5002312405 @default.
• W2964838043 hasAuthorship W2964838043A5007047764 @default.
• W2964838043 hasAuthorship W2964838043A5029885579 @default.
• W2964838043 hasAuthorship W2964838043A5039441880 @default.
• W2964838043 hasAuthorship W2964838043A5047395203 @default.
• W2964838043 hasAuthorship W2964838043A5077173527 @default.
• W2964838043 hasAuthorship W2964838043A5078465675 @default.
• W2964838043 hasAuthorship W2964838043A5086759035 @default.
• W2964838043 hasBestOaLocation W29648380431 @default.
• W2964838043 hasConcept C126322002 @default.
• W2964838043 hasConcept C142724271 @default.
• W2964838043 hasConcept C203014093 @default.
• W2964838043 hasConcept C2522874641 @default.
• W2964838043 hasConcept C2775934546 @default.
• W2964838043 hasConcept C2776029263 @default.
• W2964838043 hasConcept C2776637226 @default.
• W2964838043 hasConcept C2776914184 @default.
• W2964838043 hasConcept C2777075537 @default.
• W2964838043 hasConcept C2777382497 @default.
• W2964838043 hasConcept C2777513400 @default.
• W2964838043 hasConcept C2777766500 @default.
• W2964838043 hasConcept C2778606649 @default.
• W2964838043 hasConcept C2780593183 @default.
• W2964838043 hasConcept C2781197716 @default.
• W2964838043 hasConcept C55493867 @default.
• W2964838043 hasConcept C71924100 @default.
• W2964838043 hasConcept C86803240 @default.
• W2964838043 hasConcept C90924648 @default.
• W2964838043 hasConceptScore W2964838043C126322002 @default.
• W2964838043 hasConceptScore W2964838043C142724271 @default.
• W2964838043 hasConceptScore W2964838043C203014093 @default.
• W2964838043 hasConceptScore W2964838043C2522874641 @default.
• W2964838043 hasConceptScore W2964838043C2775934546 @default.
• W2964838043 hasConceptScore W2964838043C2776029263 @default.
• W2964838043 hasConceptScore W2964838043C2776637226 @default.
• W2964838043 hasConceptScore W2964838043C2776914184 @default.
• W2964838043 hasConceptScore W2964838043C2777075537 @default.
• W2964838043 hasConceptScore W2964838043C2777382497 @default.
• W2964838043 hasConceptScore W2964838043C2777513400 @default.

• next