Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964844997> ?p ?o ?g. }
- W2964844997 abstract "SUMMARY Dysregulation of mechanosensitive Piezo2 channels is a hallmark of mechanical allodynia, yet the cellular mechanisms that sensitize mechanoreceptors are still poorly understood. Activation of Gi-coupled receptors sensitizes Piezo2 currents, but whether Gi-coupled receptors regulate the activity of Piezo2 channels is not known. Here, we found that activation of Gi-coupled receptors potentiates Piezo2 currents in dorsal root ganglion (DRG) neurons and in heterologous systems, but inhibits Piezo1 currents in heterologous systems. The potentiation, or inhibition of Piezo currents is abolished when blocking Gβγ with the c-terminal domain of the beta-adrenergic kinase (βARKct). Pharmacological inhibition of kinases downstream of Gβγ, phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK), also abolished the potentiation of Piezo2 currents. Hence, our studies illustrate an indirect mechanism of action of Gβγ to sensitize Piezo2 currents after activation of Gi-coupled receptors." @default.
- W2964844997 created "2019-08-13" @default.
- W2964844997 creator A5003816641 @default.
- W2964844997 creator A5018298942 @default.
- W2964844997 creator A5041743824 @default.
- W2964844997 creator A5045368832 @default.
- W2964844997 creator A5068530789 @default.
- W2964844997 creator A5079009516 @default.
- W2964844997 date "2019-08-02" @default.
- W2964844997 modified "2023-10-18" @default.
- W2964844997 title "Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ" @default.
- W2964844997 cites W1492607105 @default.
- W2964844997 cites W1515479627 @default.
- W2964844997 cites W1607380607 @default.
- W2964844997 cites W1884196201 @default.
- W2964844997 cites W1928745964 @default.
- W2964844997 cites W1967930702 @default.
- W2964844997 cites W1968721371 @default.
- W2964844997 cites W1979284770 @default.
- W2964844997 cites W1992381837 @default.
- W2964844997 cites W1994115933 @default.
- W2964844997 cites W1999720993 @default.
- W2964844997 cites W2022960916 @default.
- W2964844997 cites W2029863937 @default.
- W2964844997 cites W2033072655 @default.
- W2964844997 cites W2044832274 @default.
- W2964844997 cites W2054088330 @default.
- W2964844997 cites W2073782591 @default.
- W2964844997 cites W2076156388 @default.
- W2964844997 cites W2080289814 @default.
- W2964844997 cites W2082604829 @default.
- W2964844997 cites W2083824794 @default.
- W2964844997 cites W2083884274 @default.
- W2964844997 cites W2086104179 @default.
- W2964844997 cites W2092014913 @default.
- W2964844997 cites W2102246235 @default.
- W2964844997 cites W2104154771 @default.
- W2964844997 cites W2137445147 @default.
- W2964844997 cites W2143730803 @default.
- W2964844997 cites W2143897453 @default.
- W2964844997 cites W2154939910 @default.
- W2964844997 cites W2161535250 @default.
- W2964844997 cites W2168808956 @default.
- W2964844997 cites W2184968222 @default.
- W2964844997 cites W2198274127 @default.
- W2964844997 cites W2260991120 @default.
- W2964844997 cites W2335583226 @default.
- W2964844997 cites W2338910906 @default.
- W2964844997 cites W2518806605 @default.
- W2964844997 cites W2525001998 @default.
- W2964844997 cites W2528860529 @default.
- W2964844997 cites W2530881521 @default.
- W2964844997 cites W2559212084 @default.
- W2964844997 cites W2566932600 @default.
- W2964844997 cites W2746622153 @default.
- W2964844997 cites W2747808331 @default.
- W2964844997 cites W2749835273 @default.
- W2964844997 cites W2774300852 @default.
- W2964844997 cites W2793339431 @default.
- W2964844997 cites W2802358214 @default.
- W2964844997 cites W2802857141 @default.
- W2964844997 cites W2895916051 @default.
- W2964844997 cites W2896293926 @default.
- W2964844997 cites W2896504526 @default.
- W2964844997 cites W2898266525 @default.
- W2964844997 cites W2952740422 @default.
- W2964844997 cites W882982235 @default.
- W2964844997 doi "https://doi.org/10.1101/722637" @default.
- W2964844997 hasPublicationYear "2019" @default.
- W2964844997 type Work @default.
- W2964844997 sameAs 2964844997 @default.
- W2964844997 citedByCount "0" @default.
- W2964844997 crossrefType "posted-content" @default.
- W2964844997 hasAuthorship W2964844997A5003816641 @default.
- W2964844997 hasAuthorship W2964844997A5018298942 @default.
- W2964844997 hasAuthorship W2964844997A5041743824 @default.
- W2964844997 hasAuthorship W2964844997A5045368832 @default.
- W2964844997 hasAuthorship W2964844997A5068530789 @default.
- W2964844997 hasAuthorship W2964844997A5079009516 @default.
- W2964844997 hasBestOaLocation W29648449971 @default.
- W2964844997 hasConcept C169760540 @default.
- W2964844997 hasConcept C170493617 @default.
- W2964844997 hasConcept C184235292 @default.
- W2964844997 hasConcept C185592680 @default.
- W2964844997 hasConcept C2776281502 @default.
- W2964844997 hasConcept C4001165 @default.
- W2964844997 hasConcept C50254741 @default.
- W2964844997 hasConcept C55493867 @default.
- W2964844997 hasConcept C86803240 @default.
- W2964844997 hasConcept C94487597 @default.
- W2964844997 hasConcept C95444343 @default.
- W2964844997 hasConcept C97029542 @default.
- W2964844997 hasConceptScore W2964844997C169760540 @default.
- W2964844997 hasConceptScore W2964844997C170493617 @default.
- W2964844997 hasConceptScore W2964844997C184235292 @default.
- W2964844997 hasConceptScore W2964844997C185592680 @default.
- W2964844997 hasConceptScore W2964844997C2776281502 @default.
- W2964844997 hasConceptScore W2964844997C4001165 @default.
- W2964844997 hasConceptScore W2964844997C50254741 @default.
- W2964844997 hasConceptScore W2964844997C55493867 @default.