Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964852112> ?p ?o ?g. }
- W2964852112 abstract "Abstract In all metazoans, a small number of evolutionarily conserved signaling pathways are reiteratively used during development to orchestrate critical patterning and morphogenetic processes. Among these, Notch (N) signaling is essential for most aspects of tissue patterning where it mediates the communication between adjacent cells to control cell fate specification. In Drosophila , Notch signaling is required for several features of eye development, including the R3/R4 cell fate choice and R7 specification. Here we show that hypomorphic alleles of Notch – belonging to the N facet class – reveal a novel phenotype: while photoreceptor specification in the mutant ommatidia is largely normal, defects are observed in ommatidial rotation (OR), a planar cell polarity (PCP)-mediated morphogenetic cell motility process. We demonstrate that during OR Notch signaling is specifically required in the R4 photoreceptor to upregulate the transcription of argos (aos) , an inhibitory ligand to the EGFR, to fine-tune the activity of Egfr signaling. Consistently, the loss-of-function defects of N facet alleles and EGFR-signaling pathway mutants are largely indistinguishable. A Notch-regulated aos enhancer confers R4 specific expression arguing that aos is directly regulated by Notch signaling in this context via Su(H)- Mam dependent transcription." @default.
- W2964852112 created "2019-08-13" @default.
- W2964852112 creator A5002164056 @default.
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- W2964852112 creator A5063613748 @default.
- W2964852112 date "2019-08-08" @default.
- W2964852112 modified "2023-09-27" @default.
- W2964852112 title "Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos" @default.
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- W2964852112 doi "https://doi.org/10.1101/728899" @default.
- W2964852112 hasPublicationYear "2019" @default.
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