FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964861434> ?p ?o ?g. }

• W2964861434 endingPage "417" @default.
• W2964861434 startingPage "387" @default.
• W2964861434 abstract "Abstract The main classes of clinically used antibiotics inhibit the bacterial growth interfering with the biosynthesis of proteins, nucleic acids, folate metabolism, or the formation of the microbe cell wall. Most of the existing clinical drugs are affected by the emerging phenomenon of antibiotic resistance, which can be overcome through the discovery and use of novel enzymes essentially involved in the central bacterial metabolism. In this scenario, a crucial physiologic reaction for the survival of microbes, as well as for all living organisms, is a pivotal reaction of the central bacterial metabolism: the CO2 hydration/dehydration reaction catalyzed by a superfamily of metalloenzymes, known as carbonic anhydrases (CAs, EC 4.2.1.1) and categorized into seven genetically distinct families (or classes), named α-, β-, γ-, δ-, ζ-, η-, and ɵ-CAs. These metalloenzymes are indispensable for maintaining the physiologic equilibrium of the dissolved CO2, H2CO3, HCO3−, and CO32−, which are metabolites essential for microbe biosynthesis and energy metabolism. In the last few years, numerous CAs belonging to the α-, β-, and/or γ-CA classes have been detected, cloned, and characterized in many pathogenic bacteria, and it has been demonstrated in vivo that pathogenic and nonpathogenic bacteria need functional CAs for their survival or for manifesting their virulence in the host. In this chapter, a collection of the kinetic parameters and the bacterial CA inhibition profiles with sulfonamides and their bioisosteres, and (in)organic anions is reported. These studies have highlighted the recent developments in the search for new antibacterial agents able to interfere with the growth and virulence of the microorganisms by inhibition of CAs encoded in their genomes. The present study is a starting point in the design of effective pathogenic bacteria CA inhibitors with potential use as antiinfectives." @default.
• W2964861434 created "2019-08-13" @default.
• W2964861434 creator A5035652477 @default.
• W2964861434 creator A5036969494 @default.
• W2964861434 date "2019-01-01" @default.
• W2964861434 modified "2023-10-14" @default.
• W2964861434 title "Carbonic anhydrases from pathogens" @default.
• W2964861434 cites W1511344577 @default.
• W2964861434 cites W1582613892 @default.
• W2964861434 cites W1774799325 @default.
• W2964861434 cites W1783811381 @default.
• W2964861434 cites W1834855158 @default.
• W2964861434 cites W1860492593 @default.
• W2964861434 cites W1923974573 @default.
• W2964861434 cites W1965303021 @default.
• W2964861434 cites W1971582781 @default.
• W2964861434 cites W1975965773 @default.
• W2964861434 cites W1977165276 @default.
• W2964861434 cites W1978232259 @default.
• W2964861434 cites W1978763981 @default.
• W2964861434 cites W1982203557 @default.
• W2964861434 cites W1985106162 @default.
• W2964861434 cites W1996068783 @default.
• W2964861434 cites W1998555394 @default.
• W2964861434 cites W1998860539 @default.
• W2964861434 cites W1999624783 @default.
• W2964861434 cites W2000847558 @default.
• W2964861434 cites W2002943198 @default.
• W2964861434 cites W2005153032 @default.
• W2964861434 cites W2006341400 @default.
• W2964861434 cites W2006707690 @default.
• W2964861434 cites W2010262304 @default.
• W2964861434 cites W2010314514 @default.
• W2964861434 cites W2014651956 @default.
• W2964861434 cites W2016800925 @default.
• W2964861434 cites W2018644858 @default.
• W2964861434 cites W2019716999 @default.
• W2964861434 cites W2022107477 @default.
• W2964861434 cites W2023045266 @default.
• W2964861434 cites W2024241321 @default.
• W2964861434 cites W2025322665 @default.
• W2964861434 cites W2030301261 @default.
• W2964861434 cites W2040087598 @default.
• W2964861434 cites W2040475339 @default.
• W2964861434 cites W2042295984 @default.
• W2964861434 cites W2044775220 @default.
• W2964861434 cites W2047178318 @default.
• W2964861434 cites W2048253776 @default.
• W2964861434 cites W2048478260 @default.
• W2964861434 cites W2049807128 @default.
• W2964861434 cites W2054162695 @default.
• W2964861434 cites W2054691535 @default.
• W2964861434 cites W2055476107 @default.
• W2964861434 cites W2056177496 @default.
• W2964861434 cites W2056247772 @default.
• W2964861434 cites W2057278001 @default.
• W2964861434 cites W2058128712 @default.
• W2964861434 cites W2061605654 @default.
• W2964861434 cites W2071086323 @default.
• W2964861434 cites W2072664978 @default.
• W2964861434 cites W2072828433 @default.
• W2964861434 cites W2073735425 @default.
• W2964861434 cites W2077150895 @default.
• W2964861434 cites W2077587640 @default.
• W2964861434 cites W2086311297 @default.
• W2964861434 cites W2087246081 @default.
• W2964861434 cites W2089554660 @default.
• W2964861434 cites W2090403533 @default.
• W2964861434 cites W2092344988 @default.
• W2964861434 cites W2094201044 @default.
• W2964861434 cites W2094274661 @default.
• W2964861434 cites W2098472248 @default.
• W2964861434 cites W2101715921 @default.
• W2964861434 cites W2104988217 @default.
• W2964861434 cites W2114201017 @default.
• W2964861434 cites W2127826649 @default.
• W2964861434 cites W2128090435 @default.
• W2964861434 cites W2128102076 @default.
• W2964861434 cites W2141515959 @default.
• W2964861434 cites W2145154689 @default.
• W2964861434 cites W2145385237 @default.
• W2964861434 cites W2146827229 @default.
• W2964861434 cites W2150481905 @default.
• W2964861434 cites W2151020563 @default.
• W2964861434 cites W2151689650 @default.
• W2964861434 cites W2158111073 @default.
• W2964861434 cites W2158394863 @default.
• W2964861434 cites W2159119370 @default.
• W2964861434 cites W2162747630 @default.
• W2964861434 cites W2171279511 @default.
• W2964861434 cites W2186736649 @default.
• W2964861434 cites W2189383771 @default.
• W2964861434 cites W221896903 @default.
• W2964861434 cites W2289414610 @default.
• W2964861434 cites W2293072657 @default.
• W2964861434 cites W2296680756 @default.
• W2964861434 cites W2319251167 @default.
• W2964861434 cites W2320636427 @default.

• next