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• W2964865062 startingPage "100187" @default.
• W2964865062 abstract "The prefrontal cortex (PFC) mediates higher cognition but is impaired by stress exposure when high levels of catecholamines activate calcium-cAMP-protein kinase A (PKA) signaling. The current study examined whether stress and increased cAMP-PKA signaling in rat medial PFC (mPFC) reduce pyramidal cell firing and impair working memory by activating KCNQ potassium channels. KCNQ2 channels were found in mPFC layers II/III and V pyramidal cells, and patch-clamp recordings demonstrated KCNQ currents that were increased by forskolin or by chronic stress exposure, and which were associated with reduced neuronal firing. Low dose of KCNQ blockers infused into rat mPFC improved cognitive performance and prevented acute pharmacological stress-induced deficits. Systemic administration of low doses of KCNQ blocker also improved performance in young and aged rats, but higher doses impaired performance and occasionally induced seizures. Taken together, these data demonstrate that KCNQ channels have powerful influences on mPFC neuronal firing and cognitive function, contributing to stress-induced PFC dysfunction." @default.
• W2964865062 created "2019-08-13" @default.
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• W2964865062 date "2019-11-01" @default.
• W2964865062 modified "2023-10-17" @default.
• W2964865062 title "Role of KCNQ potassium channels in stress-induced deficit of working memory" @default.
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• W2964865062 doi "https://doi.org/10.1016/j.ynstr.2019.100187" @default.
• W2964865062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6889760" @default.
• W2964865062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31832507" @default.
• W2964865062 hasPublicationYear "2019" @default.
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