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- W2964887063 abstract "在這篇論文中，我們利用原子力顯微鏡 (AFM) 來探討以雲母片為基底的脂質雙層(SLBs)在液態環境下的表面形貌。首先我們利用研究由小脂質單層囊泡 (SUV) 所得到的脂質雙層 1:1 DOPC/DPPC來最佳化樣品準備過程的實驗參數。其次，為了探討固醇對脂質雙層的影響，我們研究由小脂質單層囊泡 (SUV) 所得到的脂質雙層 1:1 POPC/DPPC 和 1:1 (POPC/DPPC) + 33mol% erg 表面形貌。為了了解溫度對脂質雙層的影響，我們也探討了在不同溫度下脂質雙層 1:1 POPC/DPPC 和 1:1 (POPC/DPPC) + 33mol% erg AFM影像。含有固醇和不含固醇的樣品表面形貌非常不同。我們觀察到在這兩種樣品的AFM影像中，都有兩種不同厚度的脂質區塊。實驗結果顯示不含固醇樣品的單一相溫度 (one-phase temperature) 高於含有固醇的樣品。此外隨著溫度上升到單一相溫度，含有固醇和不含固醇的脂質雙層有不同的熔化行為。藉由比較AFM和NMR 實驗數據，我們推測在不含固醇的樣品中，較厚的脂質區塊處於凝膠態 (gel phase)。而含有固醇的樣品中，較厚的脂質區塊處於液晶態 (liquid ordered phase)。" @default.
- W2964887063 created "2019-08-13" @default.
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- W2964887063 date "2013-01-31" @default.
- W2964887063 modified "2023-09-26" @default.
- W2964887063 title "An AFM Study on Supported Lipid Bilayers with and without Sterol" @default.
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