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• W2964889780 abstract "Abstract Objectives Surgery triggers a stress response that produces insulin resistance and hyperglycemia. During cardiac surgery, the administration of high-dose insulin along with dextrose titration maintains normoglycemia, but dramatically decreases plasma amino acids (AAs) compared with preoperative fasting levels. Hypoaminoacidemia limits protein synthesis and prevents anabolic responses after surgery. We investigated whether parenteral infusion of AAs during and immediately after cardiac surgery would prevent hypoaminoacidemia in patients who receive high-dose insulin therapy. Methods Sixteen patients undergoing coronary artery bypass grafting surgery were randomly allocated to receive AAs with % kcal equivalent to either 20% (n = 8) or 35% (n = 8) of their measured resting energy expenditure (REE). Insulin was infused at a constant rate of 5 mU/(kg × min), whereas dextrose was titrated to maintain normoglycemia during and until 5 h after surgery. Plasma AA concentrations were measured at baseline before and after surgery. Results Compared with the 20% AA group after surgery, AA concentrations were significantly higher in the 35% AA group for 12 of 20 AAs (P Conclusions AA supplementation at 35% REE, but not 20% REE, can effectively prevent hypoaminoacidemia caused by high-dose insulin therapy during cardiac surgery." @default.
• W2964889780 created "2019-08-13" @default.
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• W2964889780 date "2020-01-01" @default.
• W2964889780 modified "2023-09-24" @default.
• W2964889780 title "Parenteral amino acid supplementation with high-dose insulin prevents hypoaminoacidemia during cardiac surgery" @default.
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• W2964889780 doi "https://doi.org/10.1016/j.nut.2019.110566" @default.
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• W2964889780 hasPublicationYear "2020" @default.
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