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• W2964891395 startingPage "893" @default.
• W2964891395 abstract "Introduction: Myelodysplastic syndromes (MDS) comprise a heterogeneous group of myeloid neoplasms with diverse clinical courses. The revised version of the international prognostic scoring system (IPSS-R) provides risk stratification into 5 different groups.Areas covered: For lower-risk patients, red blood cell transfusions and iron chelation are the backbone of supportive care. In addition, erythropoiesis-stimulating agents (ESA) are used to ameliorate anemia. Lenalidomide is approved for the treatment of lower-risk patients with del(5q) who are transfusion-dependent. Patients with higher-risk disease should be offered allogeneic stem cell transplantation whenever possible. If they are unfit for transplantation or an appropriate donor cannot be found, hypomethylating agents may be used.Expert opinion: New therapeutic options for lower-risk patients include thrombopoietin analogues, the TGF-beta family ligand trapping drug Luspatercept, and the telomerase inhibitor Imetelstat. Combinations of hypomethylating agents (HMA) with other compounds, and inhibitors of bcl2, such as venetoclax are being developed for higher-risk patients. Finally, hypomethylating agents in combination with donor lymphocytes may lead to long-term remission following molecular or hematological relapse after allogeneic SCT." @default.
• W2964891395 created "2019-08-13" @default.
• W2964891395 creator A5001433615 @default.
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• W2964891395 creator A5042020284 @default.
• W2964891395 creator A5048355658 @default.
• W2964891395 creator A5068674008 @default.
• W2964891395 date "2019-07-31" @default.
• W2964891395 modified "2023-09-27" @default.
• W2964891395 title "Novel therapies in low- and high-risk myelodysplastic syndrome" @default.
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