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• W2964894988 abstract "In combination with a healthy lifestyle adoption promoted through an increasing awareness of its importance in healthy living, statins (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors) have contributed to the improved national trend seen in the prevalence of elevated levels of low-density lipoprotein cholesterol (LDL-C) [ [1] Kuklina E.V. Carroll M.D. Shaw K.M. Hirsch R. Trends in High LDL Cholesterol, Cholesterol-Lowering Medication Use, and Dietary Saturated-Fat Intake: United States, 1976-2010. NCHS Data Brief. 2013: 1-8 Google Scholar ]. In contrast to their well-established reducing effect on LDL-C levels, there has been a great deal of uncertainty to what extent statins impact lipoprotein(a) [Lp(a)] levels. At first glance, this might seem contradictory in view of the structural similarity of the Lp(a) lipid core to LDL [cholesterol-rich lipid core firmly attached to apolipoprotein (apo) B-100]. However, the LDL receptor binding site in apoB is located close to the disulfide bond linking apoB and apo(a) in Lp(a) [ [2] Cheesman E.J. Sharp R.J. Zlot C.H. Liu C.Y. Taylor S. Marcovina S.M. et al. An analysis of the interaction between mouse apolipoprotein B100 and apolipoprotein(a). J. Biol. Chem. 2000; 275: 28195-28200 Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar ]. Given the large molecular size of apo(a) as well as its high carbohydrate content, the possibility of a steric configuration that impact access of Lp(a)-apoB for the LDL receptor seems possible. The paper by Yahya et al. in this issue of Atherosclerosis provides novel perspectives on this long-term puzzle [ [3] Reyhana Yahya K.B. Verhoeven A. Bos S. van der Zee L. Touw A. Erhart G. Kronenberg F. Timman R. Sijbrands E. Roeters van Lennep J. Mulder M. Statin treatment increases lipoprotein(a) levels in subjects with low molecular weight apolipoprotein(a) phenotype. Atherosclerosis. 2019; : 201-205 Google Scholar ]. Statin treatment increases lipoprotein(a) levels in subjects with low molecular weight apolipoprotein(a) phenotypeAtherosclerosisVol. 289PreviewWe aimed to evaluate the effect of statin treatment initiation on lipoprotein(a) [Lp(a)] levels in patients with dyslipidemia, and the interactions with the apolipoprotein(a) [apo(a)] phenotype, LPA single nucleotide polymorphisms (SNPs) and change in LDL cholesterol. Full-Text PDF Open Access" @default.
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• W2964894988 date "2019-10-01" @default.
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• W2964894988 title "Statins and Lp(a): The plot thickens" @default.
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• W2964894988 doi "https://doi.org/10.1016/j.atherosclerosis.2019.07.021" @default.
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