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- W2964902986 abstract "Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to play an important role in sepsis. This review summarizes the main regulatory mechanisms of autophagy in sepsis and its latest research. Recent studies have shown that autophagy can regulate innate immune processes and acquired immune processes, and the regulation of autophagy in different immune cells is different. Mitophagy can select damaged mitochondria and remove it to deal with oxidative stress damage. The process of mitophagy is regulated by other factors. Non-coding RNA is also an important factor in the regulation of autophagy. In addition, more and more studies in recent years have shown that autophagy plays different roles in different organs. It tends to be protective in the lungs, heart, kidneys, and brain, and tends to be damaging in skeletal muscle. We also mentioned that some drugs can regulate autophagy. The process of modulating autophagy through drug intervention appears to be a new potential hope for the treatment of sepsis." @default.
- W2964902986 created "2019-08-13" @default.
- W2964902986 creator A5001530690 @default.
- W2964902986 creator A5005140228 @default.
- W2964902986 creator A5031380864 @default.
- W2964902986 creator A5042268104 @default.
- W2964902986 creator A5080088656 @default.
- W2964902986 date "2019-08-23" @default.
- W2964902986 modified "2023-10-14" @default.
- W2964902986 title "The Role of Autophagy in Sepsis: Protection and Injury to Organs" @default.
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- W2964902986 doi "https://doi.org/10.3389/fphys.2019.01071" @default.
- W2964902986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6716215" @default.