Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964932011> ?p ?o ?g. }
- W2964932011 endingPage "118522" @default.
- W2964932011 startingPage "118522" @default.
- W2964932011 abstract "The insulin/insulin-like growth factor system (IIGFs) plays a fundamental role in the regulation of prenatal and postnatal growth, metabolism and homeostasis. As a consequence, dysregulation of this axis is associated with growth disturbance, type 2 diabetes, chronic inflammation and tumor progression. A functional crosstalk between IIGFs and discoidin domain receptors (DDRs) has been recently discovered. DDRs are non-integrin collagen receptors that canonically undergo slow and long-lasting autophosphorylation after binding to fibrillar collagen. While both DDR1 and DDR2 functionally interact with IIGFs, the crosstalk with DDR1 is so far better characterized. Notably, the IIGFs-DDR1 crosstalk presents a feed-forward mechanism, which does not require collagen binding, thus identifying novel non-canonical action of DDR1. Further studies are needed to fully explore the role of this IIGFs-DDRs functional loop as potential target in the treatment of inflammatory and neoplastic disorders." @default.
- W2964932011 created "2019-08-13" @default.
- W2964932011 creator A5050819403 @default.
- W2964932011 creator A5055143240 @default.
- W2964932011 creator A5057947764 @default.
- W2964932011 creator A5070485233 @default.
- W2964932011 creator A5089369408 @default.
- W2964932011 date "2019-11-01" @default.
- W2964932011 modified "2023-09-25" @default.
- W2964932011 title "Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection" @default.
- W2964932011 cites W144423133 @default.
- W2964932011 cites W1483206320 @default.
- W2964932011 cites W1484635866 @default.
- W2964932011 cites W1531763753 @default.
- W2964932011 cites W1563179031 @default.
- W2964932011 cites W1571670108 @default.
- W2964932011 cites W1592523365 @default.
- W2964932011 cites W1827566752 @default.
- W2964932011 cites W1828238344 @default.
- W2964932011 cites W1871669466 @default.
- W2964932011 cites W1919421236 @default.
- W2964932011 cites W192348957 @default.
- W2964932011 cites W1928836998 @default.
- W2964932011 cites W1947794748 @default.
- W2964932011 cites W1965143532 @default.
- W2964932011 cites W1965602606 @default.
- W2964932011 cites W1967036346 @default.
- W2964932011 cites W1967112950 @default.
- W2964932011 cites W1967899512 @default.
- W2964932011 cites W1968873586 @default.
- W2964932011 cites W1969375564 @default.
- W2964932011 cites W1970213655 @default.
- W2964932011 cites W1970714992 @default.
- W2964932011 cites W1970865029 @default.
- W2964932011 cites W1971250281 @default.
- W2964932011 cites W1972747383 @default.
- W2964932011 cites W1973600929 @default.
- W2964932011 cites W1974502272 @default.
- W2964932011 cites W1974842079 @default.
- W2964932011 cites W1975736029 @default.
- W2964932011 cites W1976609069 @default.
- W2964932011 cites W1978002465 @default.
- W2964932011 cites W1978103469 @default.
- W2964932011 cites W1979099115 @default.
- W2964932011 cites W1979263211 @default.
- W2964932011 cites W1980106834 @default.
- W2964932011 cites W1981894827 @default.
- W2964932011 cites W1984781368 @default.
- W2964932011 cites W1989283034 @default.
- W2964932011 cites W1990073864 @default.
- W2964932011 cites W1990641591 @default.
- W2964932011 cites W1991506327 @default.
- W2964932011 cites W1991938712 @default.
- W2964932011 cites W1992002046 @default.
- W2964932011 cites W1992776819 @default.
- W2964932011 cites W1993199678 @default.
- W2964932011 cites W1996148311 @default.
- W2964932011 cites W1996464919 @default.
- W2964932011 cites W1997146974 @default.
- W2964932011 cites W1999030960 @default.
- W2964932011 cites W2000355675 @default.
- W2964932011 cites W2001957020 @default.
- W2964932011 cites W2002070144 @default.
- W2964932011 cites W2003340108 @default.
- W2964932011 cites W2003821826 @default.
- W2964932011 cites W2005666954 @default.
- W2964932011 cites W2005675755 @default.
- W2964932011 cites W2005890897 @default.
- W2964932011 cites W2009459159 @default.
- W2964932011 cites W2009665800 @default.
- W2964932011 cites W2011852093 @default.
- W2964932011 cites W2012203366 @default.
- W2964932011 cites W2012600976 @default.
- W2964932011 cites W2012738439 @default.
- W2964932011 cites W2013196990 @default.
- W2964932011 cites W2013197522 @default.
- W2964932011 cites W2013601795 @default.
- W2964932011 cites W2013614818 @default.
- W2964932011 cites W2014263971 @default.
- W2964932011 cites W2014850107 @default.
- W2964932011 cites W2016696724 @default.
- W2964932011 cites W2017141883 @default.
- W2964932011 cites W2017956201 @default.
- W2964932011 cites W2018962390 @default.
- W2964932011 cites W2019651952 @default.
- W2964932011 cites W2022274575 @default.
- W2964932011 cites W2023059800 @default.
- W2964932011 cites W2023458566 @default.
- W2964932011 cites W2026293557 @default.
- W2964932011 cites W2026415340 @default.
- W2964932011 cites W2026967508 @default.
- W2964932011 cites W2027142494 @default.
- W2964932011 cites W2030172048 @default.
- W2964932011 cites W2031253131 @default.
- W2964932011 cites W2033447440 @default.
- W2964932011 cites W2033815171 @default.
- W2964932011 cites W2034515307 @default.
- W2964932011 cites W2034769702 @default.