FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964944452> ?p ?o ?g. }

• W2964944452 endingPage "28" @default.
• W2964944452 startingPage "14" @default.
• W2964944452 abstract "Objective: The objective of the present study was to formulate a novel topical spray containing Antiacne agent. Comprising drug and other non-toxic excipients (mixture of propane and butane) LPG as propellant. Study was designed to increase the absorption of drug from the human skin. Therefore clear clinical need exists for development of suitable formulation of drug that has improved permeability and absorption, with the potential transparent thin film with the once daily dosing. An optimum formulation was to be study for skin irritation study, in-vivo drug release and finally for stability study. Experimental work: The preformulation studies for drug was carried out and compatibility of drug in formulation with different excipients was checked. Solutions for topical sprays were filled in Aluminium containers fitted with continuous spray valve. Primary screening of variables like polymers, penetration enhancers and solvents were done by preparing trial batches. Final batches were prepared comprising of polymer Eudragit E100 (flim forming polymer), penetration enhancers such as IPM and PG act as plasticizer, solvent and co-solvent such as Iso Propyl alcohol and ethanol respectively. Prepared Tazarotene topical spray formulations were evaluated for different parameters. Tazarotene topical spray included determination of delivery rate, delivery amount, pressure test, drug content, minimum fill, leakage test, flammability, spray patterns, particles size, etc and as well as In-vivo Skin irritation study and In-vitro drug released, Finally, optimised formulation Was kept for stability study as per ICH guidelines. Results and discussion: Absence of physical and chemical incompatibility during compatibility study revealed that Tazarotene is compatible with container closure and excipients. Tazarotene topical spray formulation T6 was found to be the best formulation Evaluation data of different formulation for Physico-chemical test, performance test and exvivo diffusion studies indicated the effectiveness of IPM as penetration enhancer. T6 was further proved non irritant and stability study in accordance with ICH guidelines indicated that the optimised formulation was stable. Conclusions: A novel type of formulation comprised of Tazarotene, Eudragit E100, IPM and organic volatile and non-volatile solvents, was used to develop a new topical spray formulation. This novel topical spray formulation was transparent solution with good, early evaporation and ease of application. In addition the research results showed the resultant invisible thin film with excellent carrier and permeability enhanced effect of IPM on drug. Finally, skin irritation test proved that the spray formulation was safe to be used for topical delivery. In summary, the novel formulation of Tazarotene, Eudragit E100, IPM and other excipients may provide alternate dosage form to Tazarotene gel formulation." @default.
• W2964944452 created "2019-08-13" @default.
• W2964944452 creator A5005242510 @default.
• W2964944452 creator A5039766375 @default.
• W2964944452 creator A5071882282 @default.
• W2964944452 creator A5077942248 @default.
• W2964944452 date "2017-01-01" @default.
• W2964944452 modified "2023-09-24" @default.
• W2964944452 title "Formulation and Evaluation of Topical SprayContaining Anti Acne Agent" @default.
• W2964944452 hasPublicationYear "2017" @default.
• W2964944452 type Work @default.
• W2964944452 sameAs 2964944452 @default.
• W2964944452 citedByCount "0" @default.
• W2964944452 crossrefType "journal-article" @default.
• W2964944452 hasAuthorship W2964944452A5005242510 @default.
• W2964944452 hasAuthorship W2964944452A5039766375 @default.
• W2964944452 hasAuthorship W2964944452A5071882282 @default.
• W2964944452 hasAuthorship W2964944452A5077942248 @default.
• W2964944452 hasConcept C16005928 @default.
• W2964944452 hasConcept C178790620 @default.
• W2964944452 hasConcept C185592680 @default.
• W2964944452 hasConcept C192562407 @default.
• W2964944452 hasConcept C203014093 @default.
• W2964944452 hasConcept C2777063393 @default.
• W2964944452 hasConcept C2777673923 @default.
• W2964944452 hasConcept C2779306117 @default.
• W2964944452 hasConcept C2779717098 @default.
• W2964944452 hasConcept C2779783494 @default.
• W2964944452 hasConcept C2780035454 @default.
• W2964944452 hasConcept C2780471494 @default.
• W2964944452 hasConcept C3019129585 @default.
• W2964944452 hasConcept C43617362 @default.
• W2964944452 hasConcept C45904493 @default.
• W2964944452 hasConcept C71924100 @default.
• W2964944452 hasConcept C77281830 @default.
• W2964944452 hasConcept C98274493 @default.
• W2964944452 hasConceptScore W2964944452C16005928 @default.
• W2964944452 hasConceptScore W2964944452C178790620 @default.
• W2964944452 hasConceptScore W2964944452C185592680 @default.
• W2964944452 hasConceptScore W2964944452C192562407 @default.
• W2964944452 hasConceptScore W2964944452C203014093 @default.
• W2964944452 hasConceptScore W2964944452C2777063393 @default.
• W2964944452 hasConceptScore W2964944452C2777673923 @default.
• W2964944452 hasConceptScore W2964944452C2779306117 @default.
• W2964944452 hasConceptScore W2964944452C2779717098 @default.
• W2964944452 hasConceptScore W2964944452C2779783494 @default.
• W2964944452 hasConceptScore W2964944452C2780035454 @default.
• W2964944452 hasConceptScore W2964944452C2780471494 @default.
• W2964944452 hasConceptScore W2964944452C3019129585 @default.
• W2964944452 hasConceptScore W2964944452C43617362 @default.
• W2964944452 hasConceptScore W2964944452C45904493 @default.
• W2964944452 hasConceptScore W2964944452C71924100 @default.
• W2964944452 hasConceptScore W2964944452C77281830 @default.
• W2964944452 hasConceptScore W2964944452C98274493 @default.
• W2964944452 hasIssue "24" @default.
• W2964944452 hasLocation W29649444521 @default.
• W2964944452 hasOpenAccess W2964944452 @default.
• W2964944452 hasPrimaryLocation W29649444521 @default.
• W2964944452 hasRelatedWork W1481509073 @default.
• W2964944452 hasRelatedWork W1980138230 @default.
• W2964944452 hasRelatedWork W2088762513 @default.
• W2964944452 hasRelatedWork W2339336534 @default.
• W2964944452 hasRelatedWork W2340006204 @default.
• W2964944452 hasRelatedWork W2580676279 @default.
• W2964944452 hasRelatedWork W2738623430 @default.
• W2964944452 hasRelatedWork W2783461983 @default.
• W2964944452 hasRelatedWork W2884177145 @default.
• W2964944452 hasRelatedWork W2885751744 @default.
• W2964944452 hasRelatedWork W2895224268 @default.
• W2964944452 hasRelatedWork W2906836443 @default.
• W2964944452 hasRelatedWork W2986181917 @default.
• W2964944452 hasRelatedWork W2998638887 @default.
• W2964944452 hasRelatedWork W3005782155 @default.
• W2964944452 hasRelatedWork W3130796544 @default.
• W2964944452 hasRelatedWork W2181895528 @default.
• W2964944452 hasRelatedWork W2183519349 @default.
• W2964944452 hasRelatedWork W2184651785 @default.
• W2964944452 hasRelatedWork W2331950488 @default.
• W2964944452 hasVolume "5" @default.
• W2964944452 isParatext "false" @default.
• W2964944452 isRetracted "false" @default.
• W2964944452 magId "2964944452" @default.
• W2964944452 workType "article" @default.