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• W2964965598 abstract "Background BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced inflammatory responses and delayed apoptosis with its signaling pathways in human neutrophils. Methods Isolated human neutrophils were incubated with various concentrations of BMS-470539 (1, 10, and 100 µM) in the presence or absence of LPS (100 ng/ml), and the expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β, were assessed. The effects of BMS-470539 on the expression of mitogen-activated protein kinases (MAPKs), such as p38, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, and the expression of nuclear factor kappa B (NF-κB) in LPS-stimulated human neutrophils, were evaluated by enzyme-linked immunosorbent assay. Neutrophil apoptosis was also measured by fluorescence-activated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with BMS-470539. Results BMS-470539 attenuated LPS-induced expression of pro-inflammatory cytokines, and phosphorylation of MAPKs and NF-κB. LPS stimulation reduced neutrophil apoptosis compared to the controls; however, BMS-470539 significantly inhibited the reduction of neutrophil apoptosis. Conclusions BMS-470539 can suppress the inflammatory responses of LPS-stimulated neutrophils by inhibition of MAPK pathways or NF-κB pathway, and it can also inhibit LPS-delayed neutrophil apoptosis. Keywords: Apoptosis; BMS-470539; Cytokines; Lipopolysaccharides; Mitogen-activated protein kinases; Neutrophils; nuclear factor-kappa B." @default.
• W2964965598 created "2019-08-13" @default.
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• W2964965598 date "2020-04-01" @default.
• W2964965598 modified "2023-10-16" @default.
• W2964965598 title "Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation" @default.
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• W2964965598 doi "https://doi.org/10.4097/kja.19233" @default.
• W2964965598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7113170" @default.
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