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• W2964981750 endingPage "1298" @default.
• W2964981750 startingPage "1287" @default.
• W2964981750 abstract "Polypeptides containing periodic aromatic residues in their main chains were synthesized via papain-catalyzed chemoenzymatic polymerization of tripeptide ester monomers under moderate conditions in aqueous buffers. As the monomer, 4-aminobenzoic acid (Abz) was modified with Gly or Ala at the N- and C-termini to mitigate the poor substrate specificity of papain to unnatural amino acids. The tripeptide esters, namely, GlyAbzGly and AlaAbzAla ethyl esters, can be recognized and polymerized by papain, resulting in the polypeptides poly(GlyAbzGly) and poly(AlaAbzAla), respectively, with periodic sequences containing Abz units every three residues. Copolymerization of tripeptide esters with Gly or Ala ethyl ester also proceeded in the presence of papain. The secondary structures of the Abz-containing polypeptides were investigated by IR and wide-angle X-ray diffraction (WAXD) analysis. The WAXD profile of poly(GlyAbzGly) was similar to that of polyGly, whereas poly(AlaAbzAla) adopted a sheet-like structure similar to the β-sheet of polyAla. Thermal analysis of Abz-containing polypeptides revealed that the high thermal stability of the Abz-containing polypeptides is related to the distinct sequences that periodically include Abz residues. Polypeptides containing periodic aromatic residues, 4-aminobenzoic acid (Abz), in their main chains were synthesized via papain-catalyzed chemoenzymatic polymerization of tripeptide ester monomers under moderate conditions in aqueous buffers. The secondary structures of the Abz-containing polypeptides were investigated by IR and wide-angle X-ray diffraction analysis. The WAXD profile of poly(GlyAbzGly) was similar to that of polyGly, whereas poly(AlaAbzAla) adopted a sheet-like structure similar to the β-sheet of polyAla." @default.
• W2964981750 created "2019-08-13" @default.
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• W2964981750 date "2019-08-01" @default.
• W2964981750 modified "2023-09-26" @default.
• W2964981750 title "Periodic introduction of aromatic units in polypeptides via chemoenzymatic polymerization to yield specific secondary structures with high thermal stability" @default.
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• W2964981750 doi "https://doi.org/10.1038/s41428-019-0242-z" @default.
• W2964981750 hasPublicationYear "2019" @default.
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