FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964989293> ?p ?o ?g. }

• W2964989293 endingPage "1027" @default.
• W2964989293 startingPage "1018" @default.
• W2964989293 abstract "Background: Bacillus thuringiensis toxins are effective against multiple biological targets such as insects, nematodes, mites, protozoa, and importantly, human cancer cells. One of the main mechanisms by which Cry toxins to trigger cell death is the specific recognition of cadherin-like membrane cell receptors. Objective: This work aimed to assess the cytotoxicity of the Cry1Ab and Cry1Ac toxins from Bacillus thuringiensis in HeLa, cervical cancer cell line, as well as their antitumor activity in mouse models. Methods: We analyzed several biological targets of Cry1Ab and Cry1Ac including erythrocytes, insect larvae, as well as cancer and non-cancer cell lines. The viability of HeLa, SiHa, MCF7 and HaCat cells was assessed by MTT 24 h after the administration of Cry toxins. We also studied apoptosis as a possible cytotoxicity mechanism in HeLa. The capacity of Cry toxins to eliminate tumors in xenograft mouse models was also analyzed. Results: Both toxins, Cry1Ab and Cry1Ac, showed specific cytotoxic activity in HeLa (HPV18+) cervical cancer cell line, with a Cry1Ab LC50 of 2.5 µg/ml, and of 0.5 µg/ml for Cry1Ac. Apoptosis was differentially induced in HeLa cells using the same concentration of Cry1Ab and Cry1Ac toxins. Cry1Ac eliminated 50% of the tumors at 10 µg/ml, and eliminate 100% of the tumors at 30 and 50 µg/ml. Conclusion: Bacillus thuringiensis Cry1A toxins show dual cytotoxic activity, in insects as well as in HeLa cancer cell line." @default.
• W2964989293 created "2019-08-13" @default.
• W2964989293 creator A5001760440 @default.
• W2964989293 creator A5011044886 @default.
• W2964989293 creator A5055624824 @default.
• W2964989293 creator A5080488967 @default.
• W2964989293 creator A5091305100 @default.
• W2964989293 date "2019-10-18" @default.
• W2964989293 modified "2023-10-01" @default.
• W2964989293 title "Cry1A Proteins are Cytotoxic to HeLa but not to SiHa Cervical Cancer Cells" @default.
• W2964989293 cites W1561598078 @default.
• W2964989293 cites W1579990069 @default.
• W2964989293 cites W1628033786 @default.
• W2964989293 cites W1657713622 @default.
• W2964989293 cites W1785756912 @default.
• W2964989293 cites W1964093586 @default.
• W2964989293 cites W1977551568 @default.
• W2964989293 cites W1995139888 @default.
• W2964989293 cites W1995649454 @default.
• W2964989293 cites W1997579211 @default.
• W2964989293 cites W2022207223 @default.
• W2964989293 cites W2025690227 @default.
• W2964989293 cites W2029373043 @default.
• W2964989293 cites W2035416016 @default.
• W2964989293 cites W2041553436 @default.
• W2964989293 cites W2042000201 @default.
• W2964989293 cites W2063386089 @default.
• W2964989293 cites W2094308814 @default.
• W2964989293 cites W2100837269 @default.
• W2964989293 cites W2113515344 @default.
• W2964989293 cites W2123358211 @default.
• W2964989293 cites W2144197505 @default.
• W2964989293 cites W2148358473 @default.
• W2964989293 cites W2154228322 @default.
• W2964989293 cites W2160271352 @default.
• W2964989293 cites W2163162636 @default.
• W2964989293 cites W2165481548 @default.
• W2964989293 cites W2166770364 @default.
• W2964989293 cites W2474946893 @default.
• W2964989293 cites W2527707582 @default.
• W2964989293 cites W2801985564 @default.
• W2964989293 cites W2917837889 @default.
• W2964989293 cites W2945159866 @default.
• W2964989293 cites W771563654 @default.
• W2964989293 doi "https://doi.org/10.2174/1389201020666190802114739" @default.
• W2964989293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31376817" @default.
• W2964989293 hasPublicationYear "2019" @default.
• W2964989293 type Work @default.
• W2964989293 sameAs 2964989293 @default.
• W2964989293 citedByCount "4" @default.
• W2964989293 countsByYear W29649892932020 @default.
• W2964989293 countsByYear W29649892932021 @default.
• W2964989293 countsByYear W29649892932022 @default.
• W2964989293 crossrefType "journal-article" @default.
• W2964989293 hasAuthorship W2964989293A5001760440 @default.
• W2964989293 hasAuthorship W2964989293A5011044886 @default.
• W2964989293 hasAuthorship W2964989293A5055624824 @default.
• W2964989293 hasAuthorship W2964989293A5080488967 @default.
• W2964989293 hasAuthorship W2964989293A5091305100 @default.
• W2964989293 hasConcept C102230213 @default.
• W2964989293 hasConcept C104317684 @default.
• W2964989293 hasConcept C109316439 @default.
• W2964989293 hasConcept C118995209 @default.
• W2964989293 hasConcept C121608353 @default.
• W2964989293 hasConcept C122172344 @default.
• W2964989293 hasConcept C1491633281 @default.
• W2964989293 hasConcept C153911025 @default.
• W2964989293 hasConcept C154317977 @default.
• W2964989293 hasConcept C190283241 @default.
• W2964989293 hasConcept C202751555 @default.
• W2964989293 hasConcept C2777366897 @default.
• W2964989293 hasConcept C2779035793 @default.
• W2964989293 hasConcept C2781151318 @default.
• W2964989293 hasConcept C523546767 @default.
• W2964989293 hasConcept C54355233 @default.
• W2964989293 hasConcept C55493867 @default.
• W2964989293 hasConcept C81885089 @default.
• W2964989293 hasConcept C86803240 @default.
• W2964989293 hasConcept C89423630 @default.
• W2964989293 hasConcept C96232424 @default.
• W2964989293 hasConceptScore W2964989293C102230213 @default.
• W2964989293 hasConceptScore W2964989293C104317684 @default.
• W2964989293 hasConceptScore W2964989293C109316439 @default.
• W2964989293 hasConceptScore W2964989293C118995209 @default.
• W2964989293 hasConceptScore W2964989293C121608353 @default.
• W2964989293 hasConceptScore W2964989293C122172344 @default.
• W2964989293 hasConceptScore W2964989293C1491633281 @default.
• W2964989293 hasConceptScore W2964989293C153911025 @default.
• W2964989293 hasConceptScore W2964989293C154317977 @default.
• W2964989293 hasConceptScore W2964989293C190283241 @default.
• W2964989293 hasConceptScore W2964989293C202751555 @default.
• W2964989293 hasConceptScore W2964989293C2777366897 @default.
• W2964989293 hasConceptScore W2964989293C2779035793 @default.
• W2964989293 hasConceptScore W2964989293C2781151318 @default.
• W2964989293 hasConceptScore W2964989293C523546767 @default.
• W2964989293 hasConceptScore W2964989293C54355233 @default.
• W2964989293 hasConceptScore W2964989293C55493867 @default.
• W2964989293 hasConceptScore W2964989293C81885089 @default.

• next