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• W2964996071 abstract "Abstract Background Erectile dysfunction ( ED ) is a relatively frequent disease that negatively impacts the overall quality of life, well‐being, and relationships. Although the use of phosphodiesterase 5 inhibitors ( PDE 5is) has revolutionized the treatment of ED , a high percentage of ED patients discontinue PDE 5i treatment. Objectives (i) To analyze the reasons for patient dissatisfaction leading to PDE 5i discontinuation; (ii) analyze the pharmacokinetics of new formulations focusing on the time needed to reach an effective plasma concentration of PDE 5is (T onset ) following drug intake; and (iii) summarize the physicochemical properties of sildenafil to understand which excipients may increase the absorption rate. Material and methods An online PubMed literature search was conducted to identify English language publications from inception to January 2019. Results The main reasons for patient dissatisfaction when using PDE 5is on demand are the relatively long T onset after taking vardenafil and sildenafil, including formulations such as film‐coated tablets, fine granules, orally disintegrating tablets ( ODT s), and oral thin films ( ODF s). The relatively long T onset , further worsened when accompanied by eating, highlights the following: (i) the need for planning intercourse, determining partner‐related issues; (ii) issues when having sex before the maximum effect of the drug; and (iii) lower drug‐related placebo effects. Some data suggest that sildenafil is a ‘difficult’ molecule, but T onset can be improved following absorption by buccal mucosa using appropriate excipients. Conclusions We conclude that several ODT and ODF formulations can improve the ‘discretion’ issue because they are taken without water, but they have similar pharmacokinetics to corresponding film‐coated tablet formulations. One ODF formulation of sildenafil was characterized by a shorter T onset and could potentially increase patient satisfaction following treatment. However, more clinical studies are needed to confirm the findings. Surfactants and ascorbic acid appear to be crucial excipients for achieving a high absorption rate, but more studies are needed." @default.
• W2964996071 created "2019-08-13" @default.
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• W2964996071 date "2019-07-26" @default.
• W2964996071 modified "2023-10-02" @default.
• W2964996071 title "The first‐generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue" @default.
• W2964996071 cites W1497339362 @default.
• W2964996071 cites W1504309965 @default.
• W2964996071 cites W1507601049 @default.
• W2964996071 cites W1514818611 @default.
• W2964996071 cites W1515157556 @default.
• W2964996071 cites W1529997528 @default.
• W2964996071 cites W1555238844 @default.
• W2964996071 cites W1576999553 @default.
• W2964996071 cites W1593561321 @default.
• W2964996071 cites W1837117695 @default.
• W2964996071 cites W1901039041 @default.
• W2964996071 cites W1925214338 @default.
• W2964996071 cites W1971837293 @default.
• W2964996071 cites W1972915610 @default.
• W2964996071 cites W1976410770 @default.
• W2964996071 cites W1979576003 @default.
• W2964996071 cites W1980000756 @default.
• W2964996071 cites W1985337898 @default.
• W2964996071 cites W1986403476 @default.
• W2964996071 cites W1995728313 @default.
• W2964996071 cites W1997858761 @default.
• W2964996071 cites W2003372272 @default.
• W2964996071 cites W2007974867 @default.
• W2964996071 cites W2019667886 @default.
• W2964996071 cites W2025002838 @default.
• W2964996071 cites W2028249713 @default.
• W2964996071 cites W2028515474 @default.
• W2964996071 cites W2035823248 @default.
• W2964996071 cites W2048029696 @default.
• W2964996071 cites W2050268320 @default.
• W2964996071 cites W2055953302 @default.
• W2964996071 cites W2057544547 @default.
• W2964996071 cites W2060155885 @default.
• W2964996071 cites W2062359484 @default.
• W2964996071 cites W2062396265 @default.
• W2964996071 cites W2062657251 @default.
• W2964996071 cites W2072698115 @default.
• W2964996071 cites W2075226660 @default.
• W2964996071 cites W2076357493 @default.
• W2964996071 cites W2079630871 @default.
• W2964996071 cites W2084205044 @default.
• W2964996071 cites W2087345437 @default.
• W2964996071 cites W2094560317 @default.
• W2964996071 cites W2123556288 @default.
• W2964996071 cites W2125361621 @default.
• W2964996071 cites W2126637643 @default.
• W2964996071 cites W2138440051 @default.
• W2964996071 cites W2144521788 @default.
• W2964996071 cites W2146010663 @default.
• W2964996071 cites W2159931060 @default.
• W2964996071 cites W2164902614 @default.
• W2964996071 cites W2165162887 @default.
• W2964996071 cites W2168440697 @default.
• W2964996071 cites W2194710343 @default.
• W2964996071 cites W2217456898 @default.
• W2964996071 cites W2297358297 @default.
• W2964996071 cites W2301271427 @default.
• W2964996071 cites W2409483721 @default.
• W2964996071 cites W2417122062 @default.
• W2964996071 cites W2518778874 @default.
• W2964996071 cites W2524112860 @default.
• W2964996071 cites W2581624369 @default.
• W2964996071 cites W2583894346 @default.
• W2964996071 cites W2622331064 @default.
• W2964996071 cites W2744564831 @default.
• W2964996071 cites W2763739906 @default.
• W2964996071 cites W2771008464 @default.
• W2964996071 cites W2792197840 @default.
• W2964996071 cites W2792546435 @default.
• W2964996071 cites W2808356540 @default.
• W2964996071 cites W2810793172 @default.
• W2964996071 cites W2902921810 @default.
• W2964996071 cites W2903330169 @default.
• W2964996071 cites W2903603061 @default.
• W2964996071 cites W2954829022 @default.
• W2964996071 cites W4248634338 @default.
• W2964996071 cites W70953994 @default.
• W2964996071 doi "https://doi.org/10.1111/andr.12683" @default.
• W2964996071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6790582" @default.
• W2964996071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31350821" @default.
• W2964996071 hasPublicationYear "2019" @default.
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