Matches in SemOpenAlex for { <https://semopenalex.org/work/W2964996904> ?p ?o ?g. }
- W2964996904 abstract "SUMMARY The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in early elongation, remaining engaged with the 25-60 nucleotide-long nascent RNA for many minutes while awaiting signals for release into the gene body. However, a number of genes display highly unstable promoter Pol II, suggesting that paused polymerase might dissociate from template DNA at these promoters and release a short, non-productive mRNA. Here, we report that paused Pol II can be actively destabilized by the Integrator complex. Specifically, Integrator utilizes its RNA endonuclease activity to cleave nascent RNA and drive termination of paused Pol II. These findings uncover a previously unappreciated mechanism of metazoan gene repression, akin to bacterial transcription attenuation, wherein promoter-proximal Pol II is prevented from entering productive elongation through factor-regulated termination. Highlights The Integrator complex inhibits transcription elongation at ∼15% of mRNA genes Integrator targets promoter-proximally paused Pol II for termination The RNA endonuclease of Integrator subunit 11 is critical for gene attenuation Integrator-repressed genes are enriched in signaling and growth-responsive pathways" @default.
- W2964996904 created "2019-08-13" @default.
- W2964996904 creator A5013232960 @default.
- W2964996904 creator A5026862537 @default.
- W2964996904 creator A5039045038 @default.
- W2964996904 creator A5055919781 @default.
- W2964996904 creator A5059820945 @default.
- W2964996904 creator A5062302105 @default.
- W2964996904 creator A5073767577 @default.
- W2964996904 date "2019-08-05" @default.
- W2964996904 modified "2023-09-24" @default.
- W2964996904 title "The Integrator complex terminates promoter-proximal transcription at protein-coding genes" @default.
- W2964996904 cites W1783475379 @default.
- W2964996904 cites W1863874155 @default.
- W2964996904 cites W1970047030 @default.
- W2964996904 cites W1974251842 @default.
- W2964996904 cites W1980034507 @default.
- W2964996904 cites W1981516407 @default.
- W2964996904 cites W1985567287 @default.
- W2964996904 cites W2001554877 @default.
- W2964996904 cites W2011039989 @default.
- W2964996904 cites W2018404921 @default.
- W2964996904 cites W2020120461 @default.
- W2964996904 cites W2024979146 @default.
- W2964996904 cites W2029492292 @default.
- W2964996904 cites W2032761794 @default.
- W2964996904 cites W2033997312 @default.
- W2964996904 cites W2038894647 @default.
- W2964996904 cites W2039048971 @default.
- W2964996904 cites W2045847295 @default.
- W2964996904 cites W2047266972 @default.
- W2964996904 cites W2051231585 @default.
- W2964996904 cites W2054835199 @default.
- W2964996904 cites W2057228860 @default.
- W2964996904 cites W2064210252 @default.
- W2964996904 cites W2075213761 @default.
- W2964996904 cites W2077874719 @default.
- W2964996904 cites W2078531707 @default.
- W2964996904 cites W2080240125 @default.
- W2964996904 cites W2084191969 @default.
- W2964996904 cites W2091533196 @default.
- W2964996904 cites W2101654493 @default.
- W2964996904 cites W2120650140 @default.
- W2964996904 cites W2122746312 @default.
- W2964996904 cites W2123625529 @default.
- W2964996904 cites W2124343649 @default.
- W2964996904 cites W2124985265 @default.
- W2964996904 cites W2131474341 @default.
- W2964996904 cites W2131824470 @default.
- W2964996904 cites W2133727333 @default.
- W2964996904 cites W2138207763 @default.
- W2964996904 cites W2142676369 @default.
- W2964996904 cites W2151298550 @default.
- W2964996904 cites W2152239989 @default.
- W2964996904 cites W2157373099 @default.
- W2964996904 cites W2159730169 @default.
- W2964996904 cites W2165107875 @default.
- W2964996904 cites W2170659029 @default.
- W2964996904 cites W2254385280 @default.
- W2964996904 cites W2259938310 @default.
- W2964996904 cites W2416819443 @default.
- W2964996904 cites W2498392978 @default.
- W2964996904 cites W2506039519 @default.
- W2964996904 cites W2606135333 @default.
- W2964996904 cites W2606817248 @default.
- W2964996904 cites W2615878271 @default.
- W2964996904 cites W2625585564 @default.
- W2964996904 cites W2738668193 @default.
- W2964996904 cites W2738866378 @default.
- W2964996904 cites W2745090396 @default.
- W2964996904 cites W2750519053 @default.
- W2964996904 cites W2767770944 @default.
- W2964996904 cites W2771621218 @default.
- W2964996904 cites W2785666349 @default.
- W2964996904 cites W2786204582 @default.
- W2964996904 cites W2791307854 @default.
- W2964996904 cites W2793508531 @default.
- W2964996904 cites W2796775019 @default.
- W2964996904 cites W2811461384 @default.
- W2964996904 cites W2888327454 @default.
- W2964996904 cites W2889409921 @default.
- W2964996904 cites W2914655166 @default.
- W2964996904 cites W2943054090 @default.
- W2964996904 cites W2945278782 @default.
- W2964996904 cites W2955535615 @default.
- W2964996904 cites W4252598982 @default.
- W2964996904 cites W88010964 @default.
- W2964996904 doi "https://doi.org/10.1101/725507" @default.
- W2964996904 hasPublicationYear "2019" @default.
- W2964996904 type Work @default.
- W2964996904 sameAs 2964996904 @default.
- W2964996904 citedByCount "3" @default.
- W2964996904 countsByYear W29649969042019 @default.
- W2964996904 countsByYear W29649969042020 @default.
- W2964996904 crossrefType "posted-content" @default.
- W2964996904 hasAuthorship W2964996904A5013232960 @default.
- W2964996904 hasAuthorship W2964996904A5026862537 @default.
- W2964996904 hasAuthorship W2964996904A5039045038 @default.
- W2964996904 hasAuthorship W2964996904A5055919781 @default.
- W2964996904 hasAuthorship W2964996904A5059820945 @default.