FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965014746> ?p ?o ?g. }

• W2965014746 endingPage "103649" @default.
• W2965014746 startingPage "103649" @default.
• W2965014746 abstract "Extracellular adenosine triphosphate (ATP) is as key mediator of immune and inflammatory responses. ATP is normally sequestered in the intracellular milieu and released by apoptotic and necrotic cells, where it acts as a pro-inflammatory mediator in the extracellular milieu. A limited number of studies have explored the involvement of purinergic signaling in oomycete infections, including Saprolegnia parasitica; this is a most destructive oomycete pathogen, associated with high mortality and severe economic losses for fish producers. The aim of this study was to determine whether purinergic signaling exerts anti- or pro-inflammatory effects in spleens of grass carp (Ctenopharyngodon idella) naturally infected by S. parasitica. Animals naturally infected with S. parasitica showed typical gross lesions characterized by cotton-wool tufts on the tail and fins, as well as severe histopathological lesions such as necrosis. Spleen ATP and metabolites of nitric oxide (NOx) levels were higher in fish naturally infected by S. parasitica compared to control on day 7 post-infection (PI). Spleen nucleoside triphosphate diphosphohydrolase (NTPDase) activity (ATP as substrate) was greater in fish naturally infected by S. parasitica than in uninfected on day 7 PI, while no significant differences were observed between groups with respect to NTPDase (adenosine diphosphate as substrate) and 5'-nucleotidase activities. Finally, adenosine deaminase (ADA) activity was lower in fish naturally infected by S. parasitica than in uninfected fish on day 7 PI. In summary, spleen tissue necrosis in the context of saprolegniosis provokes an intense release of ATP into the extracellular milieu, where it interacts with the P2X7 purine receptor and leads to a self-sustained pro-inflammatory deleterious cycle, contributing to an intense inflammatory process. In response to excessive ATP levels in the extracellular milieu, ATP and adenosine hydrolysis were modulated in an attempt to restrict the inflammatory process via upregulation of NTPDase and downregulation of ADA activities. We conclude that the purinergic signaling pathway modulates immune and inflammatory responses during natural infection with S. parasitica." @default.
• W2965014746 created "2019-08-13" @default.
• W2965014746 creator A5016883966 @default.
• W2965014746 creator A5022367997 @default.
• W2965014746 creator A5026532984 @default.
• W2965014746 creator A5031409772 @default.
• W2965014746 creator A5032679344 @default.
• W2965014746 creator A5033476328 @default.
• W2965014746 creator A5063691024 @default.
• W2965014746 date "2019-10-01" @default.
• W2965014746 modified "2023-09-26" @default.
• W2965014746 title "Purinergic signaling creates an anti-inflammatory profile in spleens of grass carp Ctenopharyngodon idella naturally infected by Saprolegnia parasitica: An attempt to prevent ATP pro-inflammatory effects" @default.
• W2965014746 cites W1996201104 @default.
• W2965014746 cites W1997180556 @default.
• W2965014746 cites W1999917511 @default.
• W2965014746 cites W2007723285 @default.
• W2965014746 cites W2046486371 @default.
• W2965014746 cites W2053185870 @default.
• W2965014746 cites W2054539272 @default.
• W2965014746 cites W2061976040 @default.
• W2965014746 cites W2073932252 @default.
• W2965014746 cites W2091709535 @default.
• W2965014746 cites W2121212243 @default.
• W2965014746 cites W2125574424 @default.
• W2965014746 cites W2138599948 @default.
• W2965014746 cites W2139040875 @default.
• W2965014746 cites W2397873637 @default.
• W2965014746 cites W2515633120 @default.
• W2965014746 cites W2522422048 @default.
• W2965014746 cites W2554062809 @default.
• W2965014746 cites W2619776216 @default.
• W2965014746 cites W2735847984 @default.
• W2965014746 cites W2757233225 @default.
• W2965014746 cites W2768734810 @default.
• W2965014746 cites W2778452715 @default.
• W2965014746 cites W2779261291 @default.
• W2965014746 cites W2784434888 @default.
• W2965014746 cites W2793479725 @default.
• W2965014746 cites W2890663486 @default.
• W2965014746 cites W2892467853 @default.
• W2965014746 cites W2895968160 @default.
• W2965014746 cites W2896394478 @default.
• W2965014746 cites W2910498803 @default.
• W2965014746 cites W2910890184 @default.
• W2965014746 cites W2923097937 @default.
• W2965014746 doi "https://doi.org/10.1016/j.micpath.2019.103649" @default.
• W2965014746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31374321" @default.
• W2965014746 hasPublicationYear "2019" @default.
• W2965014746 type Work @default.
• W2965014746 sameAs 2965014746 @default.
• W2965014746 citedByCount "5" @default.
• W2965014746 countsByYear W29650147462020 @default.
• W2965014746 countsByYear W29650147462021 @default.
• W2965014746 countsByYear W29650147462023 @default.
• W2965014746 crossrefType "journal-article" @default.
• W2965014746 hasAuthorship W2965014746A5016883966 @default.
• W2965014746 hasAuthorship W2965014746A5022367997 @default.
• W2965014746 hasAuthorship W2965014746A5026532984 @default.
• W2965014746 hasAuthorship W2965014746A5031409772 @default.
• W2965014746 hasAuthorship W2965014746A5032679344 @default.
• W2965014746 hasAuthorship W2965014746A5033476328 @default.
• W2965014746 hasAuthorship W2965014746A5063691024 @default.
• W2965014746 hasBestOaLocation W29650147461 @default.
• W2965014746 hasConcept C18880352 @default.
• W2965014746 hasConcept C203014093 @default.
• W2965014746 hasConcept C2776460866 @default.
• W2965014746 hasConcept C2776991684 @default.
• W2965014746 hasConcept C2777537739 @default.
• W2965014746 hasConcept C2778754761 @default.
• W2965014746 hasConcept C28406088 @default.
• W2965014746 hasConcept C34628245 @default.
• W2965014746 hasConcept C55493867 @default.
• W2965014746 hasConcept C57306754 @default.
• W2965014746 hasConcept C86803240 @default.
• W2965014746 hasConcept C89423630 @default.
• W2965014746 hasConceptScore W2965014746C18880352 @default.
• W2965014746 hasConceptScore W2965014746C203014093 @default.
• W2965014746 hasConceptScore W2965014746C2776460866 @default.
• W2965014746 hasConceptScore W2965014746C2776991684 @default.
• W2965014746 hasConceptScore W2965014746C2777537739 @default.
• W2965014746 hasConceptScore W2965014746C2778754761 @default.
• W2965014746 hasConceptScore W2965014746C28406088 @default.
• W2965014746 hasConceptScore W2965014746C34628245 @default.
• W2965014746 hasConceptScore W2965014746C55493867 @default.
• W2965014746 hasConceptScore W2965014746C57306754 @default.
• W2965014746 hasConceptScore W2965014746C86803240 @default.
• W2965014746 hasConceptScore W2965014746C89423630 @default.
• W2965014746 hasFunder F4320321091 @default.
• W2965014746 hasFunder F4320322025 @default.
• W2965014746 hasLocation W29650147461 @default.
• W2965014746 hasLocation W29650147462 @default.
• W2965014746 hasOpenAccess W2965014746 @default.
• W2965014746 hasPrimaryLocation W29650147461 @default.
• W2965014746 hasRelatedWork W1847453000 @default.
• W2965014746 hasRelatedWork W1981038111 @default.
• W2965014746 hasRelatedWork W2094803435 @default.
• W2965014746 hasRelatedWork W2118965542 @default.
• W2965014746 hasRelatedWork W2124845146 @default.

• next