FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965021000> ?p ?o ?g. }

• W2965021000 endingPage "229" @default.
• W2965021000 startingPage "221" @default.
• W2965021000 abstract "Triclosan (TCS) has been widely used as a disinfectant and antiseptic in multiple consumer and healthcare products due to its clinical effectiveness against various bacteria, fungi and protozoa. Recently, several studies have reported the adverse effects of TCS on various nerve cells, arousing concerns about its potential neurotoxicity. The present study aimed to investigate the neurotoxicity of TCS in rat pheochromocytoma PC12 cells. After differentiation, the stabilized PC12 cells were treated with 1, 10, 50 μM TCS for 12 h. At the end of the treatment, the generation of reactive oxygen species (ROS), protein expression of apoptotic-related genes, AMPK-AKT/mTOR, as well as p38 in PC12 cells were determined. The concentrations were chosen based on the results of cell viability and lactic dehydrogenase (LDH) assays in response to TCS treatment (ranging from 0.001 to 100 μM) for varied time periods. The results showed that TCS is cytotoxic to PC12 cells, causing decreased cell viability accompanied by increased LDH release. TCS treatment at 10 and 50 μM for 12 h increased the mRNA and protein expression of the pro-apoptotic gene Bax, while Bcl-2 levels remained unchanged. Moreover, an increase in the generation of reactive oxygen species (ROS) was found in TCS-treated PC12 cells at the concentrations of 1 and 10 μM. Pretreatment with 100 μM N-acetyl cysteine (NAC- ROS scavenger) for 1 h normalized the ROS generations in TCS-treated PC12 cells. Additionally, the suppression of the phosphorylation of Akt and mTOR was observed in TCS-treated PC12 cells at 10 and 50 μM for 12 h, concomitant with the activation of p38 MAPK pathway at 50 μM TCS. However, there were no effects of TCS on the phosphorylation of AMPK in these cells. Taken together, these results suggest that TCS may cause adverse effects and oxidative stress in PC12 cells accompanied by inhibition of Akt/mTOR and activation of p38." @default.
• W2965021000 created "2019-08-13" @default.
• W2965021000 creator A5028972131 @default.
• W2965021000 creator A5034593589 @default.
• W2965021000 creator A5035503566 @default.
• W2965021000 creator A5036815584 @default.
• W2965021000 creator A5072815126 @default.
• W2965021000 creator A5074331666 @default.
• W2965021000 creator A5082154691 @default.
• W2965021000 date "2019-09-01" @default.
• W2965021000 modified "2023-10-17" @default.
• W2965021000 title "Triclosan induces PC12 cells injury is accompanied by inhibition of AKT/mTOR and activation of p38 pathway" @default.
• W2965021000 cites W1755301819 @default.
• W2965021000 cites W1849485310 @default.
• W2965021000 cites W1964030921 @default.
• W2965021000 cites W1970587959 @default.
• W2965021000 cites W1982717166 @default.
• W2965021000 cites W1984097165 @default.
• W2965021000 cites W1986433868 @default.
• W2965021000 cites W1992158459 @default.
• W2965021000 cites W2008890880 @default.
• W2965021000 cites W2009638175 @default.
• W2965021000 cites W2023503340 @default.
• W2965021000 cites W2024923464 @default.
• W2965021000 cites W2027594320 @default.
• W2965021000 cites W2028971810 @default.
• W2965021000 cites W2033955368 @default.
• W2965021000 cites W2039495930 @default.
• W2965021000 cites W2042992123 @default.
• W2965021000 cites W2054590302 @default.
• W2965021000 cites W2056612024 @default.
• W2965021000 cites W2056868354 @default.
• W2965021000 cites W2062447063 @default.
• W2965021000 cites W2077318232 @default.
• W2965021000 cites W2083513354 @default.
• W2965021000 cites W2089311997 @default.
• W2965021000 cites W2093423961 @default.
• W2965021000 cites W2161237133 @default.
• W2965021000 cites W2171274949 @default.
• W2965021000 cites W2300230761 @default.
• W2965021000 cites W2319970657 @default.
• W2965021000 cites W2503430441 @default.
• W2965021000 cites W2599402689 @default.
• W2965021000 cites W2746237579 @default.
• W2965021000 cites W2770647881 @default.
• W2965021000 cites W2770869489 @default.
• W2965021000 cites W2772340427 @default.
• W2965021000 cites W2786771393 @default.
• W2965021000 cites W2790272413 @default.
• W2965021000 cites W2790667617 @default.
• W2965021000 cites W2801079612 @default.
• W2965021000 cites W2802119032 @default.
• W2965021000 cites W2802295889 @default.
• W2965021000 cites W2805697219 @default.
• W2965021000 cites W2893882601 @default.
• W2965021000 cites W2901413842 @default.
• W2965021000 cites W2901570490 @default.
• W2965021000 cites W2903156614 @default.
• W2965021000 cites W2908961518 @default.
• W2965021000 cites W2911286776 @default.
• W2965021000 cites W2918959839 @default.
• W2965021000 cites W2920035930 @default.
• W2965021000 cites W2921680889 @default.
• W2965021000 cites W2924415979 @default.
• W2965021000 cites W2936680575 @default.
• W2965021000 cites W2937074474 @default.
• W2965021000 cites W2939143006 @default.
• W2965021000 cites W2940015218 @default.
• W2965021000 doi "https://doi.org/10.1016/j.neuro.2019.07.008" @default.
• W2965021000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6750987" @default.
• W2965021000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31381933" @default.
• W2965021000 hasPublicationYear "2019" @default.
• W2965021000 type Work @default.
• W2965021000 sameAs 2965021000 @default.
• W2965021000 citedByCount "12" @default.
• W2965021000 countsByYear W29650210002020 @default.
• W2965021000 countsByYear W29650210002021 @default.
• W2965021000 countsByYear W29650210002022 @default.
• W2965021000 crossrefType "journal-article" @default.
• W2965021000 hasAuthorship W2965021000A5028972131 @default.
• W2965021000 hasAuthorship W2965021000A5034593589 @default.
• W2965021000 hasAuthorship W2965021000A5035503566 @default.
• W2965021000 hasAuthorship W2965021000A5036815584 @default.
• W2965021000 hasAuthorship W2965021000A5072815126 @default.
• W2965021000 hasAuthorship W2965021000A5074331666 @default.
• W2965021000 hasAuthorship W2965021000A5082154691 @default.
• W2965021000 hasBestOaLocation W29650210002 @default.
• W2965021000 hasConcept C153911025 @default.
• W2965021000 hasConcept C178790620 @default.
• W2965021000 hasConcept C185592680 @default.
• W2965021000 hasConcept C190283241 @default.
• W2965021000 hasConcept C2779491297 @default.
• W2965021000 hasConcept C29730261 @default.
• W2965021000 hasConcept C48349386 @default.
• W2965021000 hasConcept C51551487 @default.
• W2965021000 hasConcept C53227056 @default.
• W2965021000 hasConcept C55493867 @default.
• W2965021000 hasConcept C57074206 @default.

• next