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• W2965041398 abstract "Abstract Background Pregnancy loss is one of the most frequent pregnancy complications. It is unclear how recurrent pregnancy loss (RPL) impacts disease risk later in life and if later disease risk is different in women with or without a live birth prior to RPL (primary vs. secondary RPL). We sought to investigate if women have an increased risk of disease following RPL, and if there was a difference between primary and secondary RPL. Methods Using population-wide health care registry databases from Denmark we identified a cohort of 1,370,896 women between 12 and 40 years in the period January 1, 1977, to October 5, 2016 who had been pregnant. Each woman was followed on average for 15.8 years. Of these, 10,691 (0.77%) women fulfilled the criteria for RPL (50.0% had primary RPL). Relative Risk Ratios (RR) were calculated in a phenome-wide manner for diagnoses with a cumulative incidence proportion >0.1% in women with RPL. Diagnoses related to assessment and diagnosis of RPL and those appearing later in life were separated using a Mixture Model. Results In the full cohort of pregnant women, 0.77% (10,691) fulfilled the criteria for RPL (50.0% primary RPL). Compared to women without RPL, primary RPL increased the risk of subsequent cardiovascular disorders, including atherosclerosis (RR=2.45, 1.65-3.51 95% Uncertainty Interval (UI)), cerebral infarction (RR=1.87, 1.43-2.4 95% UI), heart failure (RR=1.97, 1.44-2.63 95% UI), and pulmonary embolism (RR=1.82, 1.32-2.46 95% UI). Women with secondary RPL had an increased risk of obstetric complications, e.g. placenta previa (RR=3.76, 2.9-4.8 95% UI), premature rupture of membrane (RR=2.55, 2.21-2.91 95% UI), intrapartum hemorrhage (RR=2.8, 1.77-4.31 95% UI), gestational hypertension (RR=2.2, 1.67-2.87 95% UI), and puerperal sepsis (RR=2.54, 1.8-3.5 95% UI). We also noticed associations to autoimmune, respiratory, gastro-intestinal and mental disorders in both subtypes. Conclusion Our findings show that RPL is a risk factor for a spectrum of disorders. This can in part be due to increased screening following RPL, but it also suggests that RPL may directly influence or share etiology with a number of diseases later in life. Research into the pathophysiology of both pregnancy loss and later diseases merits further investigation." @default.
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• W2965041398 date "2019-08-02" @default.
• W2965041398 modified "2023-09-26" @default.
• W2965041398 title "A phenome-wide analysis of short- and long-run disease incidence following Recurrent Pregnancy Loss using data from a 39-year period" @default.
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• W2965041398 doi "https://doi.org/10.1101/19003558" @default.
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